Atp2b1 (Pmca1) transports Ca2+ from the cytosol to the extracellular region

Stable Identifier
R-RNO-9664221
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Atp2b1 (Pmca1) transports Ca2+ from the cytosol to the extracellular region
Atp2b1 (Pmca1) located in the basolateral membrane of inner hair cells transports calcium ions from the cytosol to the extracellular region with concomitant hydrolysis of ATP (Dumont et al. 2001, Grati et al. 2006).
Literature References
PubMed ID Title Journal Year
11438582 Plasma membrane Ca2+-ATPase isoform 2a is the PMCA of hair bundles

Dumont, RA, Lins, U, Filoteo, AG, Penniston, JT, Kachar, B, Gillespie, PG

J. Neurosci. 2001
16803870 Molecular determinants for differential membrane trafficking of PMCA1 and PMCA2 in mammalian hair cells

Grati, M, Aggarwal, N, Strehler, EE, Wenthold, RJ

J. Cell. Sci. 2006
Participants
Input
Output
Catalyst Activity

P-type calcium transporter activity of Atp2b1 [plasma membrane]

Physical Entity
Atp2b1 [plasma membrane] (Rattus norvegicus)
Activity
P-type calcium transporter activity (GO:0005388)
Orthologous Events
ATP2B1 (PMCA1) transports Ca2+ from the cytosol to the extracellular region (Homo sapiens)
Authored
May, B  (2019-10-21)
Reviewed
Furness, DN  (2020-09-14)
Created
May, B  (2019-10-22)
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