Kcnma1:Kcnmb1 transports potassium ions from the cytosol to the extracellular region

Stable Identifier
R-RNO-9667806
Type
Reaction
Species
Rattus norvegicus
Compartment
plasma membrane
General
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PNG
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Medium
High
 | PPTX  | SBGN
Kcnma1:Kcnmb1 transports potassium ions from the cytosol to the extracellular region

Big potassium current channels (BK channels, tetramers of Kcnma1:Kcnmb1) in outer hair cells (OHCs) open in response to an influx of calcium ions, thereby causing an efflux of potassium ions which hyperpolarizes the OHC and prevents the OHC from contracting (Langer et al. 2003, Rohmann et al. 2015).

Literature References
PubMed ID Title Journal Year
12454985 Expression of Ca2+-activated BK channel mRNA and its splice variants in the rat cochlea

Gründer, S, Langer, P, Rüsch, A

J. Comp. Neurol. 2003
25653344 Activation of BK and SK channels by efferent synapses on outer hair cells in high-frequency regions of the rodent cochlea

Braude, JP, Wersinger, E, Pyott, SJ, Fuchs, PA, Rohmann, KN

J. Neurosci. 2015
Participants
Input
Output
Catalyst Activity

calcium-activated potassium channel activity of Kcnma1:Kcnmb1 [plasma membrane]

Physical Entity
Kcnma1:Kcnmb1 [plasma membrane] (Rattus norvegicus)
Activity
calcium-activated potassium channel activity (GO:0015269)
This event is regulated
Positively by
Regulator
Ca2+ [cytosol]
Orthologous Events
KCNMA1:KCNMB1 transports potassium ions from the cytosol to the extracellular region (Homo sapiens)
Authored
May, B  (2019-11-16)
Reviewed
Dallos, P  (2020-09-13)
Furness, DN  (2020-09-13)
Created
May, B  (2019-11-17)
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