cAMP:olfactory CNG channel translocates Na+ and Ca2+ from the extracellular region to the cytosol

Stable Identifier
R-RNO-9713740
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
cAMP:olfactory CNG channel translocates Na+ and Ca2+ from the extracellular region to the cytosol
The olfactory cyclic nucleotide-gated channel (CNG channel) translocates sodium and calcium cations (Na+, Ca2+) from the extracellular region to the cytosol (Liman and Buck 1994, Nache et al. 2005, Waldeck et al. 2009).
Literature References
PubMed ID Title Journal Year
19822638 Activation and desensitization of the olfactory cAMP-gated transduction channel: identification of functional modules

Frings, S, Waldeck, C, Vocke, K, Möhrlen, F, Ungerer, N

J Gen Physiol 2009
7522482 A second subunit of the olfactory cyclic nucleotide-gated channel confers high sensitivity to cAMP

Liman, ER, Buck, LB

Neuron 1994
16081488 Activation of olfactory-type cyclic nucleotide-gated channels is highly cooperative

Kusch, J, Zimmer, T, Nache, V, Schulz, E, Koopmann, R, Hagen, V, Biskup, C, Benndorf, K

J Physiol 2005
Participants
Input
Output
Catalyst Activity

monoatomic cation channel activity of cAMP:Olfactory CNG channel [plasma membrane]

Physical Entity
cAMP:Olfactory CNG channel [plasma membrane] (Rattus norvegicus)
Activity
monoatomic cation channel activity (GO:0005261)
Orthologous Events
cAMP:olfactory CNG channel translocates Na+ and Ca2+ from the extracellular region to the cytosol (Homo sapiens)
Authored
May, B  (2021-01-31)
Reviewed
Raimondi, F  (2021-08-02)
Created
May, B  (2021-01-31)
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