L-Glutamate binds Grm4 (mGluR4)

Stable Identifier
R-RNO-9737016
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
L-Glutamate binds Grm4 (mGluR4)
L-glutamate binds a truncated isoform of Grm4 (mGluR4) located on the plasma membrane of type II taste bud cells (Chaudhari et al. 1996, Chaudhari et al. 2000, Toyono et al. 2002). The truncated isoform of the receptor has approximately 100-fold less affinity for L-glutamate than the full-length isoform located in brain (Chaudhari et al. 2000). The binding of L-glutamate to Grm4 activates opening of calcium channels via a pathway that is incompletely characterized but probably involves heterotrimeric G-proteins associated with Grm4.
Literature References
PubMed ID Title Journal Year
12002614 Expression of the metabotropic glutamate receptor, mGluR4a, in the taste hairs of taste buds in rat gustatory papillae

Shigemoto, R, Kawano, S, Harada, H, Morotomi, T, Toyono, T, Kataoka, S, Seta, Y, Toyoshima, K

Arch Histol Cytol 2002
10649565 A metabotropic glutamate receptor variant functions as a taste receptor

Roper, SD, Landin, AM, Chaudhari, N

Nat Neurosci 2000
8656276 The taste of monosodium glutamate: membrane receptors in taste buds

Roper, S, Delay, E, Chaudhari, N, Lamp, C, Than, T, Cartford, C, Yang, H

J Neurosci 1996
Participants
Input
Output
Orthologous Events
L-Glutamate binds GRM4 (mGluR4) (Homo sapiens)
Authored
May, B  (2021-07-15)
Reviewed
Jiang, P  (2021-08-11)
Created
May, B  (2021-07-16)
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