L-Glutamate binds Grm1 (mGluR1)

Stable Identifier
R-RNO-9737052
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
General
SVG |   | PPTX  | SBGN
L-Glutamate binds Grm1 (mGluR1)

In taste bud cells, L-glutamate binds a truncated isoform of Grm1 (mGluR1) that has about 100x lower affinity for L-glutamate than the full-length, brain-expressed isoform does (San Gabriel et al. 2005, San Gabriel et al. 2009). Binding of L-glutamate to Grm1 activates an incompletely characterized signaling cascade that results in depolarization of the taste bud cell.

Literature References
PubMed ID Title Journal Year
19571209 Metabotropic glutamate receptor type 1 in taste tissue

San Gabriel, A, Uneyama, H, Maekawa, T, Torii, K

Am J Clin Nutr 2009
15738140 Cloning and characterization of a novel mGluR1 variant from vallate papillae that functions as a receptor for L-glutamate stimuli

San Gabriel, A, Yoshie, S, Torii, K, Uneyama, H

Chem Senses 2005
Participants
Orthologous Events
Authored
Reviewed
Created
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