Reactome | Asb18 [cytosol]

Asb18 [cytosol]

Stable Identifier

R-RNO-975418

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

ASB18, D3ZU92

Locations in the PathwayBrowser

Expand all

Immune System (Rattus norvegicus)

- Adaptive Immune System (Rattus norvegicus)
  - Class I MHC mediated antigen processing & presentation (Rattus norvegicus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Rattus norvegicus)
      - Interaction of E3 with substrate and E2-Ub complex (Rattus norvegicus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Rattus norvegicus)
        
        ASB family [cytosol] (Rattus norvegicus)
        
        Asb18 [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Rattus norvegicus)
        
        ASB family [cytosol] (Rattus norvegicus)
        
        Asb18 [cytosol] (Rattus norvegicus)
      - Polyubiquitination of substrate (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Rattus norvegicus)
        
        ASB family [cytosol] (Rattus norvegicus)
        
        Asb18 [cytosol] (Rattus norvegicus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Rattus norvegicus)
        
        ASB family [cytosol] (Rattus norvegicus)
        
        Asb18 [cytosol] (Rattus norvegicus)
        
        E3:Ub:substrate [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Rattus norvegicus)
        
        ASB family [cytosol] (Rattus norvegicus)
        
        Asb18 [cytosol] (Rattus norvegicus)
      - Release of E3 from polyubiquitinated substrate (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Rattus norvegicus)
        
        ASB family [cytosol] (Rattus norvegicus)
        
        Asb18 [cytosol] (Rattus norvegicus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Rattus norvegicus)
        
        ASB family [cytosol] (Rattus norvegicus)
        
        Asb18 [cytosol] (Rattus norvegicus)
      - Transfer of Ub from E2 to substrate and release of E2 (Rattus norvegicus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Rattus norvegicus)
        
        ASB family [cytosol] (Rattus norvegicus)
        
        Asb18 [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Rattus norvegicus)
        
        ASB family [cytosol] (Rattus norvegicus)
        
        Asb18 [cytosol] (Rattus norvegicus)
        
        E3:Ub:substrate [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Rattus norvegicus)
        
        ASB family [cytosol] (Rattus norvegicus)
        
        Asb18 [cytosol] (Rattus norvegicus)

Metabolism of proteins (Rattus norvegicus)

- Post-translational protein modification (Rattus norvegicus)
  - Neddylation (Rattus norvegicus)
    - AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Rattus norvegicus)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        Asb18 [cytosol] (Rattus norvegicus)
      - NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        Asb18 [cytosol] (Rattus norvegicus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
        
        CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        Asb18 [cytosol] (Rattus norvegicus)
      - CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        Asb18 [cytosol] (Rattus norvegicus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
        
        CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        Asb18 [cytosol] (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        Asb18 [cytosol] (Rattus norvegicus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        Asb18 [cytosol] (Rattus norvegicus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        Asb18 [cytosol] (Rattus norvegicus)
    - NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        Asb18 [cytosol] (Rattus norvegicus)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        Asb18 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:D3ZU92

Gene Names

Asb18

Reference Genes

BioGPS Gene:316614 Asb18

ENSEMBL:ENSRNOG00000019557

ENSEMBL:ENSRNOG00000019557.7 Asb18

KEGG Gene (Rattus norvegicus):316614 Asb18

Monarch:316614 Asb18

NCBI Gene:316614 Asb18

Reference Transcript

RefSeq:NM_001108231.1 Asb18

Other Identifiers

10929732

1380076_at

17866337

316614

5655363

5783170

5806624

5834363

5970697

5971194

5990283

6236650

6333942

6670001

A_43_P18638

A_44_P537090

GE1139863

GO:0005515

GO:0023052

GO:0035556

ILMN_1356504

PH_rn_0009915

Participates

as a member of

Inferred From

ASB18 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001101701.1

Ensembl

ENSRNOP00000044574, ENSRNOG00000019557, ENSRNOT00000040169

RGD

1310850

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