Reactome | Asb8 [cytosol]

Asb8 [cytosol]

Stable Identifier

R-RNO-975422

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

ASB8, A0A0G2JWD3

Locations in the PathwayBrowser

Expand all

Immune System (Rattus norvegicus)

- Adaptive Immune System (Rattus norvegicus)
  - Class I MHC mediated antigen processing & presentation (Rattus norvegicus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Rattus norvegicus)
      - Interaction of E3 with substrate and E2-Ub complex (Rattus norvegicus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Rattus norvegicus)
        
        ASB family [cytosol] (Rattus norvegicus)
        
        Asb8 [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Rattus norvegicus)
        
        ASB family [cytosol] (Rattus norvegicus)
        
        Asb8 [cytosol] (Rattus norvegicus)
      - Polyubiquitination of substrate (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Rattus norvegicus)
        
        ASB family [cytosol] (Rattus norvegicus)
        
        Asb8 [cytosol] (Rattus norvegicus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Rattus norvegicus)
        
        ASB family [cytosol] (Rattus norvegicus)
        
        Asb8 [cytosol] (Rattus norvegicus)
        
        E3:Ub:substrate [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Rattus norvegicus)
        
        ASB family [cytosol] (Rattus norvegicus)
        
        Asb8 [cytosol] (Rattus norvegicus)
      - Release of E3 from polyubiquitinated substrate (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Rattus norvegicus)
        
        ASB family [cytosol] (Rattus norvegicus)
        
        Asb8 [cytosol] (Rattus norvegicus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Rattus norvegicus)
        
        ASB family [cytosol] (Rattus norvegicus)
        
        Asb8 [cytosol] (Rattus norvegicus)
      - Transfer of Ub from E2 to substrate and release of E2 (Rattus norvegicus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Rattus norvegicus)
        
        ASB family [cytosol] (Rattus norvegicus)
        
        Asb8 [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Rattus norvegicus)
        
        ASB family [cytosol] (Rattus norvegicus)
        
        Asb8 [cytosol] (Rattus norvegicus)
        
        E3:Ub:substrate [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Rattus norvegicus)
        
        ASB family [cytosol] (Rattus norvegicus)
        
        Asb8 [cytosol] (Rattus norvegicus)

Metabolism of proteins (Rattus norvegicus)

- Post-translational protein modification (Rattus norvegicus)
  - Neddylation (Rattus norvegicus)
    - AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Rattus norvegicus)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        Asb8 [cytosol] (Rattus norvegicus)
      - NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        Asb8 [cytosol] (Rattus norvegicus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
        
        CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        Asb8 [cytosol] (Rattus norvegicus)
      - CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        Asb8 [cytosol] (Rattus norvegicus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
        
        CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        Asb8 [cytosol] (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        Asb8 [cytosol] (Rattus norvegicus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        Asb8 [cytosol] (Rattus norvegicus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        Asb8 [cytosol] (Rattus norvegicus)
    - NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        Asb8 [cytosol] (Rattus norvegicus)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        Asb8 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:A0A0G2JWD3

Gene Names

Asb8

Reference Genes

ENSEMBL:ENSRNOG00000010099

ENSEMBL:ENSRNOG00000010099.8 Asb8

Other Identifiers

10906819

1373289_at

1383535_at

17840672

315287

5690854

6205589

6516268

6537811

A_44_P405775

A_64_P119279

GE16168

GO:0005515

GO:0023052

GO:0035556

ILMN_1351695

PH_rn_0006860

rc_AI070624_at

Participates

as a member of

Inferred From

ASB8 [cytosol] (Homo sapiens)

Cross References

Ensembl

ENSRNOT00000079377, ENSRNOG00000010099, ENSRNOP00000069835

RGD

1309246

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