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p-T177-CDK6:CCND [nucleoplasm]
Stable Identifier
R-RNO-9756822
Type
Set [DefinedSet]
Species
Rattus norvegicus
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cell Cycle (Rattus norvegicus)
Cell Cycle, Mitotic (Rattus norvegicus)
Mitotic G1 phase and G1/S transition (Rattus norvegicus)
G1 Phase (Rattus norvegicus)
Cyclin D associated events in G1 (Rattus norvegicus)
CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
Drug-mediated inhibition of CDK4/CDK6 activity (Rattus norvegicus)
CDK6 inhibitors bind CDK6 (Rattus norvegicus)
p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
Participants
members
p-T177-CDK6:CCND1 [nucleoplasm]
(Rattus norvegicus)
p-T177-CDK6:CCND2 [nucleoplasm]
(Rattus norvegicus)
p-T177-CDK6:CCND3 [nucleoplasm]
(Rattus norvegicus)
Participates
as an input of
CDK6 inhibitors bind CDK6 (Rattus norvegicus)
as a member of
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Rattus norvegicus)
Inferred From
p-T177-CDK6:CCND [nucleoplasm]
(Homo sapiens)
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