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Cul3 [cytosol]
Stable Identifier
R-RNO-975979
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
CUL3, B5DF89
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Class I MHC mediated antigen processing & presentation (Rattus norvegicus)
Antigen processing: Ubiquitination & Proteasome degradation (Rattus norvegicus)
Interaction of E3 with substrate and E2-Ub complex (Rattus norvegicus)
Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
Polyubiquitination of substrate (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
E3:Ub:substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
Release of E3 from polyubiquitinated substrate (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
Transfer of Ub from E2 to substrate and release of E2 (Rattus norvegicus)
Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
E3:Ub:substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Neddylation (Rattus norvegicus)
AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Rattus norvegicus)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Rattus norvegicus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Rattus norvegicus)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
MAPK family signaling cascades (Rattus norvegicus)
MAPK1/MAPK3 signaling (Rattus norvegicus)
RAF/MAP kinase cascade (Rattus norvegicus)
Regulation of RAS by GAPs (Rattus norvegicus)
KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Rattus norvegicus)
KBTBD7:CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Rattus norvegicus)
RHOBTB3 ATPase cycle (Rattus norvegicus)
RHOBTB3 binds interacting proteins at trans-Golgi network (Rattus norvegicus)
RHOBTB3 interacting proteins [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
RHOBTB3:ATP:RHOBTB3 interacting proteins [trans-Golgi network membrane] (Rattus norvegicus)
RHOBTB3 interacting proteins [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
Signaling by Rho GTPases (Rattus norvegicus)
RHO GTPase cycle (Rattus norvegicus)
RHOBTB GTPase Cycle (Rattus norvegicus)
RHOBTB1 GTPase cycle (Rattus norvegicus)
RHOBTB1 binds interacting proteins at the endosome membrane (Rattus norvegicus)
RHOBTB1 interacting proteins [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
RHOBTB1:GTP:RHOBTB1 interacting proteins [endosome membrane] (Rattus norvegicus)
RHOBTB1 interacting proteins [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
RHOBTB2 GTPase cycle (Rattus norvegicus)
RHOBTB2 binds interacting proteins at the endosome membrane (Rattus norvegicus)
RHOBTB2 interacting proteins [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
RHOBTB2:GTP:RHOBTB2 interacting proteins [endosome membrane] (Rattus norvegicus)
RHOBTB2 interacting proteins [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
Signaling by WNT (Rattus norvegicus)
TCF dependent signaling in response to WNT (Rattus norvegicus)
Degradation of DVL (Rattus norvegicus)
DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Rattus norvegicus)
CUL3:KLHL12:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
DVL:CUL3:KLHL12:RBX1 [cytosol] (Rattus norvegicus)
CUL3:KLHL12:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Rattus norvegicus)
DVL:CUL3:KLHL12:RBX1 [cytosol] (Rattus norvegicus)
CUL3:KLHL12:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
ub-DVL:CUL3:KLHL12:RBX1 [cytosol] (Rattus norvegicus)
CUL3:KLHL12:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
Ubiquitinated DVL is degraded by the proteasome (Rattus norvegicus)
CUL3:KLHL12:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
ub-DVL:CUL3:KLHL12:RBX1 [cytosol] (Rattus norvegicus)
CUL3:KLHL12:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:B5DF89
Gene Names
Cul3
Reference Genes
ENSEMBL:ENSRNOG00000015633
ENSEMBL:ENSRNOG00055006821
ENSEMBL:ENSRNOG00060007351
ENSEMBL:ENSRNOG00065018395
UCSC:B5DF89 Cul3
Reference Transcript
RefSeq:XM_008767226.2 Cul3
RefSeq:XM_017596374.1 Cul3
RefSeq:XM_017596375.1 Cul3
Participates
as a member of
RHOBTB1 interacting proteins [cytosol] (Rattus norvegicus)
RHOBTB2 interacting proteins [cytosol] (Rattus norvegicus)
RHOBTB3 interacting proteins [cytosol] (Rattus norvegicus)
as a component of
CUL3:KLHL12:RBX1 [cytosol] (Rattus norvegicus)
KBTBD7:CUL3:RBX1 [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
Other forms of this molecule
Cul3 [cytosol]
Cul3 [nucleoplasm]
Inferred From
CUL3 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_017451864.1
,
XP_008765448.1
,
XP_017451863.1
PRO
B5DF89
RGD
1308190
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