Reactome | Fbxw11 [cytosol]

Fbxw11 [cytosol]

Stable Identifier

R-RNO-976035

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

FBXW11, A0A0G2JVE0

Locations in the PathwayBrowser

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Cell Cycle (Rattus norvegicus)

- Cell Cycle, Mitotic (Rattus norvegicus)
  - Mitotic G2-G2/M phases (Rattus norvegicus)
    - G2/M Transition (Rattus norvegicus)
      - Regulation of PLK1 Activity at G2/M Transition (Rattus norvegicus)
        
        Phosphorylated BORA binds SCF-beta-TrCp1/2 (Rattus norvegicus)
        
        (BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Rattus norvegicus)
        
        CUL1:FBXW11:SKP1 [cytosol] (Rattus norvegicus)
        
        Fbxw11 [cytosol] (Rattus norvegicus)
        
        p-S252,S497,T501-BORA:SCF-beta-TrCp1/2 [cytosol] (Rattus norvegicus)
        
        (BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Rattus norvegicus)
        
        CUL1:FBXW11:SKP1 [cytosol] (Rattus norvegicus)
        
        Fbxw11 [cytosol] (Rattus norvegicus)
        
        SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Rattus norvegicus)
        
        (BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Rattus norvegicus)
        
        CUL1:FBXW11:SKP1 [cytosol] (Rattus norvegicus)
        
        Fbxw11 [cytosol] (Rattus norvegicus)
        
        p-S252,S497,T501-BORA:SCF-beta-TrCp1/2 [cytosol] (Rattus norvegicus)
        
        (BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Rattus norvegicus)
        
        CUL1:FBXW11:SKP1 [cytosol] (Rattus norvegicus)
        
        Fbxw11 [cytosol] (Rattus norvegicus)

Metabolism of proteins (Rattus norvegicus)

- Post-translational protein modification (Rattus norvegicus)
  - Neddylation (Rattus norvegicus)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw11 [cytosol] (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw11 [cytosol] (Rattus norvegicus)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw11 [cytosol] (Rattus norvegicus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
        
        CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw11 [cytosol] (Rattus norvegicus)
      - CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw11 [cytosol] (Rattus norvegicus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
        
        CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw11 [cytosol] (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw11 [cytosol] (Rattus norvegicus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw11 [cytosol] (Rattus norvegicus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw11 [cytosol] (Rattus norvegicus)
    - MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw11 [cytosol] (Rattus norvegicus)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw11 [cytosol] (Rattus norvegicus)
    - NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw11 [cytosol] (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxw11 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:A0A0G2JVE0

Gene Names

Fbxw11

Reference Genes

ENSEMBL:ENSRNOG00000004395

ENSEMBL:ENSRNOG00000004395.8 Fbxw11

Other Identifiers

10732697

1374412_at

17644923

303024

5624474

5874538

5937104

6059471

6086230

6086405

6097788

6229219

6285147

6391655

6542792

6623387

6652841

A_42_P626104

GE1181096

GE18165

GO:0005515

GO:0046983

PH_rn_0010803

rc_AI009208_at

Participates

as a member of

as a component of

CUL1:FBXW11:SKP1 [cytosol] (Rattus norvegicus)

Inferred From

FBXW11 [cytosol] (Homo sapiens)

Cross References

Ensembl

ENSRNOT00000079698, ENSRNOP00000069447, ENSRNOG00000004395

RGD

1309121

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