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Keap1 [cytosol]
Stable Identifier
R-RNO-976038
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
KEAP1, P57790
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular response to chemical stress (Rattus norvegicus)
KEAP1-NFE2L2 pathway (Rattus norvegicus)
CUL3:RBX1 ubiquitinates KEAP1 (Rattus norvegicus)
SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Rattus norvegicus)
p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
SESN1,SESN1 bind SQSTM1 and KEAP1 (Rattus norvegicus)
SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Class I MHC mediated antigen processing & presentation (Rattus norvegicus)
Antigen processing: Ubiquitination & Proteasome degradation (Rattus norvegicus)
Interaction of E3 with substrate and E2-Ub complex (Rattus norvegicus)
Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
BTB proteins [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
BTB proteins [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
Polyubiquitination of substrate (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
BTB proteins [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
BTB proteins [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
E3:Ub:substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
BTB proteins [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
Release of E3 from polyubiquitinated substrate (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
BTB proteins [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
BTB proteins [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
Transfer of Ub from E2 to substrate and release of E2 (Rattus norvegicus)
Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
BTB proteins [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
BTB proteins [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
E3:Ub:substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
BTB proteins [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Deubiquitination (Rattus norvegicus)
Ub-specific processing proteases (Rattus norvegicus)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Rattus norvegicus)
USP15:SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Rattus norvegicus)
SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
Neddylation (Rattus norvegicus)
AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Rattus norvegicus)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
BTB proteins [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
NEDD8-CUL3:RBX1:BTB [cytosol] (Rattus norvegicus)
BTB proteins [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Rattus norvegicus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
BTB proteins [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
BTB proteins [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
BTB proteins [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
BTB proteins [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
BTB proteins [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
NEDD8-CUL3:RBX1:BTB [cytosol] (Rattus norvegicus)
BTB proteins [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Rattus norvegicus)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
BTB proteins [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
BTB proteins [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Keap1 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P57790
Gene Names
Keap1
Reference Genes
ENSEMBL:ENSRNOG00000020878
UCSC:P57790 Keap1
Participates
as a member of
SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Rattus norvegicus)
BTB proteins [cytosol] (Rattus norvegicus)
as a component of
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Other forms of this molecule
Keap1 [cytosol]
Keap1 [cytosol]
Inferred From
KEAP1 [cytosol]
(Homo sapiens)
Cross References
PRO
P57790
RGD
621619
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