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Spata2 [cytosol]
Stable Identifier
R-RNO-9796351
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
SPATA2, Q66HP6
Locations in the PathwayBrowser
Expand all
Signal Transduction (Rattus norvegicus)
Death Receptor Signaling (Rattus norvegicus)
TNF signaling (Rattus norvegicus)
Regulation of TNFR1 signaling (Rattus norvegicus)
CHUK, IKBKB phosphorylate RIPK1 at S25 (Rattus norvegicus)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
Spata2 [cytosol] (Rattus norvegicus)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
Spata2 [cytosol] (Rattus norvegicus)
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
Spata2 [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
Spata2 [cytosol] (Rattus norvegicus)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
Spata2 [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
Spata2 [cytosol] (Rattus norvegicus)
CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
Spata2 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
Spata2 [cytosol] (Rattus norvegicus)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
Spata2 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
Spata2 [cytosol] (Rattus norvegicus)
OPTN recruits CYLD to the TNFR1 complex (Rattus norvegicus)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
Spata2 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
Spata2 [cytosol] (Rattus norvegicus)
SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
Spata2 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
Spata2 [cytosol] (Rattus norvegicus)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
Spata2 [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
Spata2 [cytosol] (Rattus norvegicus)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
Spata2 [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
Spata2 [cytosol] (Rattus norvegicus)
TNFR1-induced NF-kappa-B signaling pathway (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
Spata2 [cytosol] (Rattus norvegicus)
TNFR1-induced proapoptotic signaling (Rattus norvegicus)
TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1 (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
Spata2 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q66HP6
Gene Names
Spata2
Reference Genes
ENSEMBL:ENSRNOG00000009207
UCSC:Q66HP6 Spata2
Other Identifiers
10851960
114210
1393503_at
1398274_at
17779579
5765039
5789527
5934880
6027017
6064005
6199215
6349082
A_43_P12892
A_64_P027833
GE1152267
GE1160143
GO:0001650
GO:0005634
GO:0005654
GO:0005737
GO:0007283
GO:0010803
GO:0012501
GO:0022414
GO:0030159
GO:0043226
GO:0044877
GO:0048856
GO:0050727
GO:0060090
GO:0060544
GO:0070266
GO:0070536
GO:0072520
GO:1990108
GO:1990381
ILMN_1355928
PH_rn_0009377
rc_AA997729_at
Participates
as a component of
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
Inferred From
SPATA2 [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSRNOG00000009207
,
ENSRNOT00000012604
,
ENSRNOP00000012604
PRO
Q66HP6
RGD
620754
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