Reactome | phospho-p-S218,S222-MAP2K1 [cytosol]

phospho-p-S218,S222-MAP2K1 [cytosol]

Stable Identifier

R-SCE-109837

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

P06784

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P06784

Reference Genes

BioGPS Gene:851396

ENSEMBL:YDL159W

KEGG:sce:YDL159W

Monarch:851396

NCBI Gene:851396

SGD:YDL159W

UCSC:P06784

Reference Transcript

RefSeq:NM_001180219.1

Other Identifiers

1769361_at

6661_at

851396

GO:0000165

GO:0000166

GO:0000187

GO:0000196

GO:0000278

GO:0000747

GO:0001402

GO:0001403

GO:0003674

GO:0004672

GO:0004674

GO:0004708

GO:0004713

GO:0005515

GO:0005524

GO:0005575

GO:0005737

GO:0006468

GO:0007124

GO:0007346

GO:0008150

GO:0010525

GO:0016301

GO:0016310

GO:0016740

GO:0018193

GO:0019236

GO:0023052

GO:0030427

GO:0031098

GO:0032196

GO:0042221

GO:0042981

GO:0043167

GO:0043332

GO:0051726

GO:0071507

GO:0071554

GO:0106310

Participates

as a member of

MAP2K1 [cytosol] (Saccharomyces cerevisiae)

as an output of

Dissociation of p-T,Y-MAPK3:MAP2K1 (Saccharomyces cerevisiae)

as an input of

MAP2K1 binds MAPK3 (Saccharomyces cerevisiae)

as a component of

Other forms of this molecule

phospho-p-S,218, S222,T292 MAP2K1 [cytosol]

phospho-p-S,T-MAP2K2 [cytosol]

phospho-p-T286,T292-MAP2K1 [cytosol]

phospho-p-S218,S222,T286,T292-MAP2K1 [cytosol]

MAP2K1 [cytosol]

phospho-p-S222,S226-MAP2K2 [cytosol]

Inferred From

p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)

Modified Residues

Name

O-phospho-L-serine at 218 (in Homo sapiens)

Coordinate

218

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 222 (in Homo sapiens)

Coordinate

222

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_010122.1

ENSEMBL

YDL159W_mRNA

PRO

P06784

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P14681	20	phospho-p-T185,Y187-MAPK1 [nucleoplasm] (R-SCE-112354) phospho-p-T202,Y204-MAPK3 [nucleoplasm] (R-SCE-112359) phospho-p-T202,Y204-MAPK3 [cytosol] (R-SCE-109842) phospho-p-T185,Y187-MAPK1 [cytosol] (R-SCE-109853) MAPK1 [cytosol] (R-SCE-59282) MAPK3 [cytosol] (R-SCE-59284) MAPK3 [nucleoplasm] (R-SCE-73724) MAPK1 [nucleoplasm] (R-SCE-199960) phospho-p-T185-MAPK1 [cytosol] (R-SCE-9635773) phospho-p-T202-MAPK3 [cytosol] (R-SCE-9635775) NLK [cytosol] (R-SCE-4411330) phospho-p-T298-NLK [cytosol] (R-SCE-4411398) phospho-p-T298-NLK [nucleoplasm] (R-SCE-4411376) MAPK1 [azurophil granule lumen] (R-SCE-6799225) MAPK1 [extracellular region] (R-SCE-6806250) MAPK1 [ficolin-1-rich granule lumen] (R-SCE-6800964) phospho-p-3S,T MAPK6 [nucleoplasm] (R-SCE-5692665) MAPK6 [nucleoplasm] (R-SCE-5692686) phospho-p-S189 MAPK6 [nucleoplasm] (R-SCE-5687015) phospho-p-S186 MAPK4 [nucleoplasm] (R-SCE-5687022)	0.945	17
UniProt:P16892	20	phospho-p-T185,Y187-MAPK1 [nucleoplasm] (R-SCE-112354-2) phospho-p-T202,Y204-MAPK3 [nucleoplasm] (R-SCE-112359-2) phospho-p-T202,Y204-MAPK3 [cytosol] (R-SCE-109842-2) phospho-p-T185,Y187-MAPK1 [cytosol] (R-SCE-109853-2) MAPK1 [cytosol] (R-SCE-59282-2) MAPK3 [cytosol] (R-SCE-59284-2) phospho-p-T218,Y221-MAPK7 [nucleoplasm] (R-SCE-198738) phospho-p-T218,Y221-MAPK7 [cytosol] (R-SCE-198721) MAPK7 [nucleoplasm] (R-SCE-199961) MAPK3 [nucleoplasm] (R-SCE-73724-2) MAPK1 [nucleoplasm] (R-SCE-199960-2) phospho-p-T185-MAPK1 [cytosol] (R-SCE-9635773-2) phospho-p-T202-MAPK3 [cytosol] (R-SCE-9635775-2) NLK [cytosol] (R-SCE-4411330-2) phospho-p-T298-NLK [cytosol] (R-SCE-4411398-2) phospho-p-T298-NLK [nucleoplasm] (R-SCE-4411376-2) MAPK1 [azurophil granule lumen] (R-SCE-6799225-2) MAPK1 [extracellular region] (R-SCE-6806250-2) MAPK1 [ficolin-1-rich granule lumen] (R-SCE-6800964-2) phospho-p-3S,T MAPK6 [nucleoplasm] (R-SCE-5692665-2)	0.932	15
UniProt:P32917 STE5			0.819	9
UniProt:P32485	20	phospho-p-T221,Y223-MAPK10 [nucleoplasm] (R-SCE-450311) phospho-p-T183,Y185-MAPK9 [nucleoplasm] (R-SCE-450319) phospho-p-T,Y-MAPK8 [nucleoplasm] (R-SCE-216349) phospho-p-T180,Y182-MAPK14 [nucleoplasm] (R-SCE-446227) phospho-p-T180,Y182-MAPK11 [nucleoplasm] (R-SCE-198741) phospho-p-T180,Y182-MAPK14 [cytosol] (R-SCE-428935) MAPK14 [cytosol] (R-SCE-428933) phospho-p-T221,Y223-MAPK10 [cytosol] (R-SCE-450214) phospho-p-T,Y-MAPK8 [cytosol] (R-SCE-194371) phospho-p-T183,Y185-MAPK9 [cytosol] (R-SCE-450293) MAPK9 [cytosol] (R-SCE-450355) MAPK10 [cytosol] (R-SCE-450352) MAPK8 [cytosol] (R-SCE-168141) MAPK12 [cytosol] (R-SCE-171025) MAPK13 [cytosol] (R-SCE-171012) MAPK11 [cytosol] (R-SCE-170989) phospho-p-T180,Y182-MAPK11 [cytosol] (R-SCE-171009) phospho-p-T180,Y182-MAPK13 [cytosol] (R-SCE-171022) phospho-p-T183,Y185-MAPK12 [cytosol] (R-SCE-171021) MAPK14 [secretory granule lumen] (R-SCE-6803300)	0.499	2
UniProt:Q00684	3	CDC14 [cytosol] (R-SCE-174094) CDC14 [nucleoplasm] (R-SCE-5692694) CDC14 [nucleoplasm] (R-SCE-3214897)	0.499	2

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