Reactome | phospho-p-T202,Y204-MAPK3 [nucleoplasm]

phospho-p-T202,Y204-MAPK3 [nucleoplasm]

Stable Identifier

R-SCE-112359

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

nucleoplasm

Synonyms

P14681

Locations in the PathwayBrowser

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Cellular responses to stimuli (Saccharomyces cerevisiae)

- Cellular responses to stress (Saccharomyces cerevisiae)
  - Cellular Senescence (Saccharomyces cerevisiae)
    - Senescence-Associated Secretory Phenotype (SASP) (Saccharomyces cerevisiae)
      - ERK1/2/5 activate RSK1/2/3 (Saccharomyces cerevisiae)
        
        p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Saccharomyces cerevisiae)
        
        p-T202, Y204 MAPK3 dimer [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of p-T202,Y204-MAPK3 [nucleoplasm] (Saccharomyces cerevisiae)
        
        phospho-p-T202,Y204-MAPK3 [nucleoplasm] (Saccharomyces cerevisiae)

Developmental Biology (Saccharomyces cerevisiae)

- Nervous system development (Saccharomyces cerevisiae)
  - Axon guidance (Saccharomyces cerevisiae)
    - NCAM signaling for neurite out-growth (Saccharomyces cerevisiae)
      - ERK1/2 phosphorylates MSK1 (Saccharomyces cerevisiae)
        
        p-T,Y MAPK dimers [nucleoplasm] (Saccharomyces cerevisiae)
        
        p-T202, Y204 MAPK3 dimer [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of p-T202,Y204-MAPK3 [nucleoplasm] (Saccharomyces cerevisiae)
        
        phospho-p-T202,Y204-MAPK3 [nucleoplasm] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P14681

Reference Genes

BioGPS Gene:852931

ENSEMBL:YGR040W

KEGG Gene (Saccharomyces cerevisiae (strain YJM789)):YGR040W

Monarch:852931

NCBI Gene:852931

SGD:YGR040W

Reference Transcript

RefSeq:NM_001181169.3

Other Identifiers

1775178_at

4966_at

852931

GO:0000165

GO:0000166

GO:0000747

GO:0000750

GO:0000910

GO:0001402

GO:0001403

GO:0003674

GO:0004672

GO:0004674

GO:0004707

GO:0005515

GO:0005524

GO:0005575

GO:0005634

GO:0005737

GO:0005933

GO:0005935

GO:0006468

GO:0007049

GO:0008134

GO:0008150

GO:0010973

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0030427

GO:0035556

GO:0042221

GO:0042597

GO:0043167

GO:0043433

GO:0043934

GO:0043935

GO:0051321

GO:0051726

GO:0106310

Participates

as a member of

Homologues of p-T202,Y204-MAPK3 [nucleoplasm] (Saccharomyces cerevisiae)

Other forms of this molecule

MAPK1 [azurophil granule lumen]

MAPK1 [extracellular region]

MAPK1 [ficolin-1-rich granule lumen]

phospho-p-T202-MAPK3 [cytosol]

phospho-p-T185-MAPK1 [cytosol]

MAPK1 [nucleoplasm]

MAPK3 [nucleoplasm]

MAPK3 [cytosol]

MAPK1 [cytosol]

phospho-p-T185,Y187-MAPK1 [cytosol]

phospho-p-T202,Y204-MAPK3 [cytosol]

phospho-p-T185,Y187-MAPK1 [nucleoplasm]

Inferred From

p-T202,Y204-MAPK3 [nucleoplasm] (Homo sapiens)

Modified Residues

Name

O-phospho-L-threonine at 202 (in Homo sapiens)

Coordinate

202

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O4'-phospho-L-tyrosine at 204 (in Homo sapiens)

Coordinate

204

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_011554.3

IntEnz

2.7.11.24

PRO

P14681

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06784	17	phospho-p-S218,S222-MAP2K1 [cytosol] (R-SCE-109837) phospho-p-S222,S226-MAP2K2 [cytosol] (R-SCE-169292) MAP2K1 [cytosol] (R-SCE-59502) phospho-p-S218,S222,T286,T292-MAP2K1 [cytosol] (R-SCE-112339) phospho-p-T286,T292-MAP2K1 [cytosol] (R-SCE-112374) MAP2K4 [cytosol] (R-SCE-168107) phospho-p-S257,T261-MAP2K4 [cytosol] (R-SCE-168170) phospho-p-S,T-MAP2K2 [cytosol] (R-SCE-109848) phospho-p-S271,T275-MAP2K7 [cytosol] (R-SCE-450353) MAP2K7 [cytosol] (R-SCE-450276) phospho-p-S189,T193-MAP2K3 [nucleoplasm] (R-SCE-450229) phospho-p-S207,T211-MAP2K6 [nucleoplasm] (R-SCE-450258) phospho-p-S189,T193-MAP2K3 [cytosol] (R-SCE-167955) phospho-p-S207,T211-MAP2K6 [cytosol] (R-SCE-206255) MAP2K3 [cytosol] (R-SCE-168051) MAP2K6 [cytosol] (R-SCE-167998) phospho-p-S,218, S222,T292 MAP2K1 [cytosol] (R-SCE-5674490)	0.945	17
UniProt:P13574 STE12			0.868	9
UniProt:P23561	1	MAP3K5 [cytosol] (R-SCE-167709)	0.667	6
UniProt:Q03063 DIG1			0.659	5
UniProt:Q03373 DIG2			0.659	5
UniProt:P33306 BCK2			0.623	5
UniProt:P02829	11	HSP90AA1 [secretory granule lumen] (R-SCE-6801515) HSP90AB1 [secretory granule lumen] (R-SCE-6801477) HSP90AB1 [extracellular region] (R-SCE-6806463) HSP90AA1 [extracellular region] (R-SCE-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-SCE-6801470) HSP90AB1 [ficolin-1-rich granule lumen] (R-SCE-6801491) HSP90AA1 [plasma membrane] (R-SCE-534996) HSP90AB1 [cytosol] (R-SCE-419617) HSP90AA1 [nucleoplasm] (R-SCE-5082401) HSP90AB1 [nucleoplasm] (R-SCE-5082399) HSP90AA1 [cytosol] (R-SCE-192864)	0.547	2
UniProt:Q06108 RGC1			0.527	3
UniProt:P18412	4	TEC1 [nucleoplasm] (R-SCE-2032774) TEC1 [nucleoplasm] (R-SCE-2032763) TEC1 [nucleoplasm] (R-SCE-2032780) TEC1 [nucleoplasm] (R-SCE-2032767)	0.527	3
UniProt:P40061	1	TSC11 [cytosol] (R-SCE-198632)	0.527	2

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