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phospho-p-S2,S5(CTD)-POLR2A [nucleoplasm]
Stable Identifier
R-SCE-113420
Type
Protein [EntityWithAccessionedSequence]
Species
Saccharomyces cerevisiae
Compartment
nucleoplasm
Synonyms
P04050
Locations in the PathwayBrowser
Expand all
DNA Repair (Saccharomyces cerevisiae)
Nucleotide Excision Repair (Saccharomyces cerevisiae)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Saccharomyces cerevisiae)
Formation of TC-NER Pre-Incision Complex (Saccharomyces cerevisiae)
Active RNA Pol II complex transcribes lesion-containing DNA template (Saccharomyces cerevisiae)
Damaged dsDNA with open transcription bubble:Hyperphosphorylated RNA Pol II:TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Saccharomyces cerevisiae)
phospho-p-S2,S5(CTD)-POLR2A [nucleoplasm] (Saccharomyces cerevisiae)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Saccharomyces cerevisiae)
phospho-p-S2,S5(CTD)-POLR2A [nucleoplasm] (Saccharomyces cerevisiae)
ERCC6 binds stalled RNA Pol II (Saccharomyces cerevisiae)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Saccharomyces cerevisiae)
phospho-p-S2,S5(CTD)-POLR2A [nucleoplasm] (Saccharomyces cerevisiae)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Saccharomyces cerevisiae)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Saccharomyces cerevisiae)
phospho-p-S2,S5(CTD)-POLR2A [nucleoplasm] (Saccharomyces cerevisiae)
ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Saccharomyces cerevisiae)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Saccharomyces cerevisiae)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Saccharomyces cerevisiae)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Saccharomyces cerevisiae)
phospho-p-S2,S5(CTD)-POLR2A [nucleoplasm] (Saccharomyces cerevisiae)
RNA Pol II initiates transcription from damaged DNA template (Saccharomyces cerevisiae)
Damaged dsDNA with open transcription bubble:Hyperphosphorylated RNA Pol II:TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Saccharomyces cerevisiae)
phospho-p-S2,S5(CTD)-POLR2A [nucleoplasm] (Saccharomyces cerevisiae)
Gene expression (Transcription) (Saccharomyces cerevisiae)
RNA Polymerase II Transcription (Saccharomyces cerevisiae)
Generic Transcription Pathway (Saccharomyces cerevisiae)
Transcriptional Regulation by TP53 (Saccharomyces cerevisiae)
TP53 Regulates Transcription of DNA Repair Genes (Saccharomyces cerevisiae)
CCNK:CDK12 binds RNA Pol II at DNA repair genes (Saccharomyces cerevisiae)
CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Saccharomyces cerevisiae)
Elongation Complex at DNA Repair Genes [nucleoplasm] (Saccharomyces cerevisiae)
Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Saccharomyces cerevisiae)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Saccharomyces cerevisiae)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Saccharomyces cerevisiae)
phospho-p-S2,S5(CTD)-POLR2A [nucleoplasm] (Saccharomyces cerevisiae)
Elongation Complex at DNA Repair Genes [nucleoplasm] (Saccharomyces cerevisiae)
Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Saccharomyces cerevisiae)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Saccharomyces cerevisiae)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Saccharomyces cerevisiae)
phospho-p-S2,S5(CTD)-POLR2A [nucleoplasm] (Saccharomyces cerevisiae)
CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Saccharomyces cerevisiae)
CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Saccharomyces cerevisiae)
Elongation Complex at DNA Repair Genes [nucleoplasm] (Saccharomyces cerevisiae)
Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Saccharomyces cerevisiae)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Saccharomyces cerevisiae)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Saccharomyces cerevisiae)
phospho-p-S2,S5(CTD)-POLR2A [nucleoplasm] (Saccharomyces cerevisiae)
Metabolism of RNA (Saccharomyces cerevisiae)
Processing of Capped Intron-Containing Pre-mRNA (Saccharomyces cerevisiae)
Formation of pre-mRNPs (Saccharomyces cerevisiae)
capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Saccharomyces cerevisiae)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Saccharomyces cerevisiae)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Saccharomyces cerevisiae)
phospho-p-S2,S5(CTD)-POLR2A [nucleoplasm] (Saccharomyces cerevisiae)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Saccharomyces cerevisiae)
capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Saccharomyces cerevisiae)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Saccharomyces cerevisiae)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Saccharomyces cerevisiae)
phospho-p-S2,S5(CTD)-POLR2A [nucleoplasm] (Saccharomyces cerevisiae)
Signal Transduction (Saccharomyces cerevisiae)
Signaling by Nuclear Receptors (Saccharomyces cerevisiae)
ESR-mediated signaling (Saccharomyces cerevisiae)
Estrogen-dependent gene expression (Saccharomyces cerevisiae)
p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Saccharomyces cerevisiae)
MYB gene:hyperphosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Saccharomyces cerevisiae)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Saccharomyces cerevisiae)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Saccharomyces cerevisiae)
phospho-p-S2,S5(CTD)-POLR2A [nucleoplasm] (Saccharomyces cerevisiae)
External Reference Information
External Reference
UniProt:P04050
Reference Genes
BioGPS Gene:851415
ENSEMBL:YDL140C
KEGG:sce:YDL140C
Monarch:851415
NCBI Gene:851415
SGD:YDL140C
UCSC:P04050
Reference Transcript
RefSeq:NM_001180200.1
Other Identifiers
1775403_at
6635_at
851415
GO:0000428
GO:0001055
GO:0001172
GO:0003674
GO:0003677
GO:0003899
GO:0003968
GO:0005515
GO:0005575
GO:0005634
GO:0005665
GO:0005737
GO:0005739
GO:0005773
GO:0006281
GO:0006351
GO:0006352
GO:0006354
GO:0006366
GO:0006367
GO:0006368
GO:0006974
GO:0008150
GO:0008270
GO:0010494
GO:0016740
GO:0016779
GO:0019985
GO:0034062
GO:0043167
GO:0046872
Participates
as a component of
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Saccharomyces cerevisiae)
Other forms of this molecule
POLR2A [nucleoplasm]
phospho-p-S5(CTD)-POLR2A [nucleoplasm]
phospho-p-3S-POLR2A [nucleoplasm]
phospho-Ub,p-S2,S5(CTD)-POLR2A [nucleoplasm]
phospho-p-S5,S7(CTD)-POLR2A [nucleoplasm]
Inferred From
p-S2,S5(CTD)-POLR2A [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 1843 (in Homo sapiens)
Coordinate
1843
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1847 (in Homo sapiens)
Coordinate
1847
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1850 (in Homo sapiens)
Coordinate
1850
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1857 (in Homo sapiens)
Coordinate
1857
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1861 (in Homo sapiens)
Coordinate
1861
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1864 (in Homo sapiens)
Coordinate
1864
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1868 (in Homo sapiens)
Coordinate
1868
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1871 (in Homo sapiens)
Coordinate
1871
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1875 (in Homo sapiens)
Coordinate
1875
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1878 (in Homo sapiens)
Coordinate
1878
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1882 (in Homo sapiens)
Coordinate
1882
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1889 (in Homo sapiens)
Coordinate
1889
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1892 (in Homo sapiens)
Coordinate
1892
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1896 (in Homo sapiens)
Coordinate
1896
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1899 (in Homo sapiens)
Coordinate
1899
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1906 (in Homo sapiens)
Coordinate
1906
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1910 (in Homo sapiens)
Coordinate
1910
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1913 (in Homo sapiens)
Coordinate
1913
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1917 (in Homo sapiens)
Coordinate
1917
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1920 (in Homo sapiens)
Coordinate
1920
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1924 (in Homo sapiens)
Coordinate
1924
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1927 (in Homo sapiens)
Coordinate
1927
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1931 (in Homo sapiens)
Coordinate
1931
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1934 (in Homo sapiens)
Coordinate
1934
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
ENSEMBL
YDL140C
,
YDL140C_mRNA
,
YDL140C
IntEnz
2.7.7.6
PRO
P04050
PDB
6BLP
,
8UKR
,
4A93
,
8TVY
,
2E2I
,
2VUM
,
4V1M
,
3GTJ
,
5VKL
,
7UIO
,
4A3M
,
8TVW
,
8TUG
,
3H3V
,
1I6H
,
8K5P
,
6GYK
,
7MKA
,
5FMF
,
7RIQ
,
8UOQ
,
2B8K
,
3S1M
,
2NVX
,
6UQ0
,
6BM2
,
8UKU
,
5SVA
,
2JA8
,
4X67
,
2E2J
,
2YU9
,
8UOT
,
3J1N
,
1R5U
,
1TWC
,
3RZD
,
5OQJ
,
8U9X
,
4BXZ
,
5W51
,
3S16
,
9BW0
,
1PQV
,
9JA1
,
5C3E
,
5C4X
,
3HOY
,
1Y1Y
,
7RIW
,
4A3C
,
2R93
,
2JA7
,
4V1N
,
3GTG
,
4A3I
,
8CEN
,
3GTL
,
7RIM
,
5W4U
,
3GTQ
,
6UQ3
,
6BLO
,
3HOU
,
6I84
,
7O75
,
7NKX
,
4Y52
,
5VVS
,
5VVR
,
7ZSB
,
7ML0
,
3S2D
,
5IP9
,
3K7A
,
4A3E
,
1Y1W
,
3M4O
,
1NT9
,
3S1N
,
5FZ5
,
3CQZ
,
2NVT
,
1TWH
,
8UKS
,
3HOZ
,
5U5Q
,
2E2H
,
8JCH
,
4A3G
,
3GTP
,
3GTK
,
3S1Q
,
1TWA
,
1WCM
,
6BM4
,
5VKO
,
3S17
,
3M3Y
,
7ML1
,
7O4I
,
7O73
,
3K1F
,
7ZS9
,
3J0K
,
5IP7
,
4A3D
,
7KED
,
2R7Z
,
4V1O
,
2NVZ
,
8UKQ
,
2JA6
,
1I50
,
3GTO
,
6UPX
,
3RZO
,
3S1R
,
4Y7N
,
3HOW
,
7O4J
,
6GYL
,
8TVP
,
4GWQ
,
3PO3
,
4A3K
,
2NVQ
,
1R9S
,
5LVF
,
1SFO
,
8CEO
,
7KEF
,
5M9D
,
7UIF
,
3I4M
,
3I4N
,
2LO6
,
1TWG
,
2R92
,
4BBR
,
3GTM
,
5OQM
,
6UQ2
,
5C4A
,
7NKY
,
4BY7
,
7O4K
,
3HOV
,
7MK9
,
3PO2
,
4A3J
,
7O4L
,
8TVS
,
1R9T
,
7KEE
,
5FYW
,
1Y1V
,
2L0I
,
5OT2
,
8UKT
,
2JA5
,
4X6A
,
9BVT
,
4A3F
,
6UPY
,
3QT1
,
5C44
,
7O72
,
7ZSA
,
1K83
,
7ML4
,
8TVV
,
3S2H
,
4A3L
,
3S15
,
7RIY
,
7RIP
,
2NVY
,
6UQ1
,
8U9R
,
1TWF
,
6GYM
,
7UIG
,
6O6C
,
1Y77
,
4BBS
,
6UPZ
,
6BQF
,
3FKI
,
1I3Q
,
7ML2
,
7MEI
,
2B63
,
8TVQ
,
8TVX
,
4BY1
,
4BXX
,
6NPW
,
3S14
,
5C4J
,
7UI9
,
7RIX
,
3HOX
,
4A3B
,
1NIK
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P27692
1
phospho-SPT5 [nucleoplasm]
(R-SCE-3009372)
0.864
13
UniProt:P22696
2
ESS1 [cytosol]
(R-SCE-9626823)
ESS1 [nucleoplasm]
(R-SCE-936016)
0.669
4
UniProt:P32914
1
SPT4 [nucleoplasm]
(R-SCE-64905)
0.669
8
UniProt:Q05543
3
RTT103 [nucleoplasm]
(R-SCE-6814906)
RTT103 [nucleoplasm]
(R-SCE-6814894)
RTT103 [nucleoplasm]
(R-SCE-6814899)
0.564
17
UniProt:P46995
4
SET2 [nucleoplasm]
(R-SCE-1183232)
SET2 [nucleoplasm]
(R-SCE-1183230)
phospho-SET2 [nucleoplasm]
(R-SCE-5682984)
SET2 [nucleoplasm]
(R-SCE-1183215)
0.564
5
UniProt:P39940
8
RSP5 [cytosol]
(R-SCE-975995)
RSP5 [cytosol]
(R-SCE-976003)
RSP5 [cytosol]
(R-SCE-173537)
RSP5 [cytosol]
(R-SCE-975972)
RSP5 [cytosol]
(R-SCE-976037)
RSP5 [cytosol]
(R-SCE-8851656)
RSP5 [cytosol]
(R-SCE-975992)
RSP5 [cytosol]
(R-SCE-6807279)
0.527
2
UniProt:P10592
20
SSA2 [cytosol]
(R-SCE-264476)
SSA2 [nucleoplasm]
(R-SCE-5082380)
SSA2 [cytosol]
(R-SCE-3371410-3)
SSA2 [cytosol]
(R-SCE-3371408-3)
SSA2 [cytosol]
(R-SCE-6792602-3)
SSA2 [ficolin-1-rich granule lumen]
(R-SCE-6801512-3)
SSA2 [ficolin-1-rich granule lumen]
(R-SCE-6801496-3)
SSA2 [ficolin-1-rich granule lumen]
(R-SCE-6801494)
SSA2 [extracellular region]
(R-SCE-6805872-3)
SSA2 [extracellular region]
(R-SCE-6806500-3)
SSA2 [extracellular region]
(R-SCE-6805936)
SSA2 [secretory granule lumen]
(R-SCE-6801530)
SSA2 [secretory granule lumen]
(R-SCE-6801472-3)
SSA2 [nucleoplasm]
(R-SCE-6792605-3)
SSA2 [nucleoplasm]
(R-SCE-912480-3)
SSA2 [nucleoplasm]
(R-SCE-5082367-3)
SSA2 [nucleoplasm]
(R-SCE-5252082-3)
SSA2 [nucleoplasm]
(R-SCE-5252088-3)
SSA2 [nucleoplasm]
(R-SCE-5252009-3)
SSA2 [cytosol]
(R-SCE-5251948-3)
0.527
2
UniProt:P40084
1
RPAP2 [nucleoplasm]
(R-SCE-6810227)
0.527
2
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