Reactome | HHT2 [nucleoplasm]

HHT2 [nucleoplasm]

Stable Identifier

R-SCE-1214206

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

nucleoplasm

Synonyms

Me2K5-H3F3A, P61830

Locations in the PathwayBrowser

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Cell Cycle (Saccharomyces cerevisiae)

- Cell Cycle, Mitotic (Saccharomyces cerevisiae)
  - M Phase (Saccharomyces cerevisiae)
    - Mitotic Prophase (Saccharomyces cerevisiae)
      - Condensation of Prophase Chromosomes (Saccharomyces cerevisiae)
        
        PHF8 demethylates histone H4K20me1 (Saccharomyces cerevisiae)
        
        PHF8:Nucleosome with H3K4me2/3 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Nucleosome with H3K4me2/3 [nucleoplasm] (Saccharomyces cerevisiae)
        
        H3K4me2/3 [nucleoplasm] (Saccharomyces cerevisiae)
        
        H3K4me2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        HHT2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        H3K4me2/3 [nucleoplasm] (Saccharomyces cerevisiae)
        
        H3K4me2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        HHT2 [nucleoplasm] (Saccharomyces cerevisiae)

Signal Transduction (Saccharomyces cerevisiae)

- Signaling by Nuclear Receptors (Saccharomyces cerevisiae)
  - ESR-mediated signaling (Saccharomyces cerevisiae)
    - Estrogen-dependent gene expression (Saccharomyces cerevisiae)
      - FOXA1 and GATA3 bind to CCND1 promoter (Saccharomyces cerevisiae)
        
        CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Nucleosome with H3K4me2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Histone H3 (H3K4me2) [nucleoplasm] (Saccharomyces cerevisiae)
        
        HHT2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        CCND1 gene:H3K4me2 nucleosome:YY1:HDAC1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Nucleosome with H3K4me2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Histone H3 (H3K4me2) [nucleoplasm] (Saccharomyces cerevisiae)
        
        HHT2 [nucleoplasm] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P61830

Gene Names

HHT2

Reference Genes

BioGPS Gene:852295 HHT2

BioGPS Gene:855700 HHT2

ENSEMBL:YBR010W

KEGG:sce:YBR010W HHT2

KEGG:sce:YNL031C HHT2

Monarch:852295 HHT2

Monarch:855700 HHT2

NCBI Gene:852295 HHT2

NCBI Gene:855700 HHT2

SGD:YBR010W

UCSC:P61830 HHT2

Reference Transcript

Other Identifiers

1773019_at

1775541_at

7368_i_at

7369_s_at

852295

855700

8910_at

GO:0000500

GO:0000786

GO:0000788

GO:0003674

GO:0003677

GO:0003682

GO:0005198

GO:0005515

GO:0005575

GO:0005634

GO:0005694

GO:0005730

GO:0006091

GO:0006281

GO:0006325

GO:0006333

GO:0006334

GO:0006355

GO:0006360

GO:0006873

GO:0006878

GO:0006974

GO:0008150

GO:0008823

GO:0009060

GO:0009303

GO:0016491

GO:0030527

GO:0031298

GO:0031492

GO:0032991

GO:0042790

GO:0043505

GO:0043934

GO:0043935

GO:0045333

GO:0045943

GO:0046982

GO:0051321

GO:0070911

Participates

as a candidate of

H3K4me2 [nucleoplasm] (Saccharomyces cerevisiae)

as a member of

Histone H3 (H3K4me2) [nucleoplasm] (Saccharomyces cerevisiae)

Other forms of this molecule

HHT2 [nucleoplasm]

phospho-HHT2 [nucleoplasm]

HHT2 [nucleoplasm]

phospho-HHT2 [nucleoplasm]

HHT2 [nucleoplasm]

Inferred From

Me2K5-H3F3A [nucleoplasm] (Homo sapiens)

Modified Residues

Name

N6,N6-dimethyl-L-lysine at 5 (in Homo sapiens)

Coordinate

PsiMod Name

N6,N6-dimethyl-L-lysine [MOD:00084]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6,N6-dimethyl-L-lysine.

Cross References

RefSeq

NP_009564.1, NP_014367.1

ENSEMBL

YNL031C, YBR010W, YBR010W_mRNA, YBR010W, YNL031C_mRNA, YNL031C

PRO

P61830

PDB

8I3F, 7UQJ, 7F4E, 6GEJ, 7F4A, 8GHN, 1PU9, 7E9F, 7E9C, 1PUA, 2IDC, 2RSN, 4PSX, 3MP1, 1QSN, 5D7E, 3Q33, 4JJN, 1PEG, 7XAY, 3MP6, 2CNX, 2JMJ, 7Z0O, 7F5M, 2RNW, 5ZBB, 1ID3, 5ZBA, 6KMJ, 2H2G, 2RNX, 6GEN, 6J2P, 1M1D, 7F3S, 4KUD, 7K7G, 5IOK

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02309	14	HHF2 [nucleoplasm] (R-SCE-181902) HHF2 [nucleoplasm] (R-SCE-5651652) HHF2 [nucleoplasm] (R-SCE-3451124) HHF2 [nucleoplasm] (R-SCE-5423110) HHF2 [nucleoplasm] (R-SCE-4568758) HHF2 [nucleoplasm] (R-SCE-4568748) HHF2 [nucleoplasm] (R-SCE-427469) HHF2 [nucleoplasm] (R-SCE-5651656) HHF2 [nucleoplasm] (R-SCE-4754240) HHF2 [nucleoplasm] (R-SCE-4754243) HHF2 [nucleoplasm] (R-SCE-5229015) HHF2 [nucleoplasm] (R-SCE-4568744) HHF2 [nucleoplasm] (R-SCE-212078) HHF2 [nucleoplasm] (R-SCE-4570518)	0.921	72
UniProt:Q04636	1	POB3 [nucleoplasm] (R-SCE-65105)	0.758	34
UniProt:P32447	1	ASF1 [nucleoplasm] (R-SCE-417169)	0.752	36
UniProt:P43609	2	SMARCC2 [nucleoplasm] (R-SCE-389263-2) SMARCC1 [nucleoplasm] (R-SCE-389257)	0.669	4
UniProt:P32558	1	SPT16 [nucleoplasm] (R-SCE-112415)	0.669	37
UniProt:P46995	4	SET2 [nucleoplasm] (R-SCE-1183232) SET2 [nucleoplasm] (R-SCE-1183230) phospho-SET2 [nucleoplasm] (R-SCE-5682984) SET2 [nucleoplasm] (R-SCE-1183215)	0.623	2
UniProt:P29469 MCM2	2	MCM2 [nucleoplasm] (R-SCE-68557) yMcm2 [nucleoplasm] (R-SCE-169497)	0.527	2
UniProt:P32598	1	PPP1CC [cytosol] (R-SCE-163443)	0.527	2