Reactome | MCD1 [nucleoplasm]

MCD1 [nucleoplasm]

Stable Identifier

R-SCE-163042

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

nucleoplasm

Synonyms

RAD21, Q12158

Locations in the PathwayBrowser

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Cell Cycle (Saccharomyces cerevisiae)

- Cell Cycle, Mitotic (Saccharomyces cerevisiae)
  - S Phase (Saccharomyces cerevisiae)
    - Establishment of Sister Chromatid Cohesion (Saccharomyces cerevisiae)
      - Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Saccharomyces cerevisiae)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere [nucleoplasm] (Saccharomyces cerevisiae)
        
        Ac-Cohesin:PDS5:WAPAL [nucleoplasm] (Saccharomyces cerevisiae)
        
        Ac-Cohesin Complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of RAD21 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCD1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Cohesin:PDS5:WAPAL:Centromere [nucleoplasm] (Saccharomyces cerevisiae)
        
        Cohesin:PDS5:WAPAL [nucleoplasm] (Saccharomyces cerevisiae)
        
        Cohesin Complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of RAD21 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCD1 [nucleoplasm] (Saccharomyces cerevisiae)
      - Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Saccharomyces cerevisiae)
        
        Ac-Cohesin:PDS5:WAPAL:Chromosomal Arm [nucleoplasm] (Saccharomyces cerevisiae)
        
        Ac-Cohesin:PDS5:WAPAL [nucleoplasm] (Saccharomyces cerevisiae)
        
        Ac-Cohesin Complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of RAD21 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCD1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Cohesin:PDS5:WAPAL:Chromosomal Arm [nucleoplasm] (Saccharomyces cerevisiae)
        
        Cohesin:PDS5:WAPAL [nucleoplasm] (Saccharomyces cerevisiae)
        
        Cohesin Complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of RAD21 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCD1 [nucleoplasm] (Saccharomyces cerevisiae)

Metabolism of proteins (Saccharomyces cerevisiae)

- Post-translational protein modification (Saccharomyces cerevisiae)
  - SUMOylation (Saccharomyces cerevisiae)
    - SUMO E3 ligases SUMOylate target proteins (Saccharomyces cerevisiae)
      - SUMOylation of DNA damage response and repair proteins (Saccharomyces cerevisiae)
        
        SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Saccharomyces cerevisiae)
        
        Cohesin Complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of RAD21 [nucleoplasm] (Saccharomyces cerevisiae)
        
        MCD1 [nucleoplasm] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:Q12158

Gene Names

MCD1

Reference Genes

BioGPS Gene:851561 MCD1

ENSEMBL:YDL003W

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YDL003W MCD1

Monarch:851561 MCD1

NCBI Gene:851561 MCD1

SGD:YDL003W

Reference Transcript

RefSeq:NM_001180062.1 MCD1

Other Identifiers

1775495_at

6459_at

851561

GO:0000278

GO:0000775

GO:0000794

GO:0003674

GO:0003682

GO:0005515

GO:0005575

GO:0005634

GO:0005694

GO:0005737

GO:0005739

GO:0006281

GO:0006302

GO:0006310

GO:0006473

GO:0006915

GO:0006974

GO:0007049

GO:0007059

GO:0007062

GO:0007064

GO:0007076

GO:0008150

GO:0008278

GO:0019899

GO:0019901

GO:0030892

GO:0034087

GO:0034990

GO:0043543

GO:0048285

GO:0051301

GO:1990414

Participates

as a member of

Homologues of RAD21 [nucleoplasm] (Saccharomyces cerevisiae)

Other forms of this molecule

MCD1 [nucleoplasm]

phospho-MCD1 [cytosol]

phospho-MCD1 [chromosome]

MCD1 [cytosol]

phospho-MCD1 [cytosol]

MCD1 [cytosol]

MCD1 [chromosome]

MCD1 [chromosome, centromeric region]

Inferred From

RAD21 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_010281.1

PRO

Q12158

PDB

5FRS, 6H8Q, 6QPW, 1W1W, 6ZZ6, 4UX3, 5FRP, 6QPQ

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P32562	5	PLK1 [nucleoplasm] (R-SCE-156720) PLK3 [nucleoplasm] (R-SCE-3222161) phospho-p-T210-PLK1 [cytosol] (R-SCE-3000318) phospho-p-T210-PLK1 [nucleoplasm] (R-SCE-3002800) PLK1 [cytosol] (R-SCE-164603)	0.643	3
UniProt:P10592	20	SSA2 [cytosol] (R-SCE-264476) SSA2 [nucleoplasm] (R-SCE-5082380) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801512-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801496-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801494) SSA2 [extracellular region] (R-SCE-6805872-3) SSA2 [extracellular region] (R-SCE-6806500-3) SSA2 [extracellular region] (R-SCE-6805936) SSA2 [secretory granule lumen] (R-SCE-6801530) SSA2 [secretory granule lumen] (R-SCE-6801472-3) SSA2 [cytosol] (R-SCE-3371410-3) SSA2 [cytosol] (R-SCE-3371408-3) SSA2 [cytosol] (R-SCE-6792602-3) SSA2 [nucleoplasm] (R-SCE-6792605-3) SSA2 [nucleoplasm] (R-SCE-912480-3) SSA2 [nucleoplasm] (R-SCE-5082367-3) SSA2 [nucleoplasm] (R-SCE-5252082-3) SSA2 [nucleoplasm] (R-SCE-5252088-3) SSA2 [nucleoplasm] (R-SCE-5252009-3) SSA2 [cytosol] (R-SCE-5251948-3)	0.527	2