Reactome | phospho-p-T218,Y221-MAPK7 [cytosol]

phospho-p-T218,Y221-MAPK7 [cytosol]

Stable Identifier

R-SCE-198721

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

P16892

Locations in the PathwayBrowser for interactor UniProt:Q03063 DIG1

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External Reference Information

External Reference

UniProt:P16892

Reference Genes

BioGPS Gene:852265

ENSEMBL:YBL016W

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YBL016W

Monarch:852265

NCBI Gene:852265

SGD:YBL016W

Reference Transcript

RefSeq:NM_001178256.1

Other Identifiers

1772084_at

2458_g_at

7391_at

852265

GO:0000166

GO:0000747

GO:0000750

GO:0001403

GO:0003674

GO:0004672

GO:0004674

GO:0004707

GO:0005515

GO:0005524

GO:0005575

GO:0005634

GO:0005737

GO:0005739

GO:0006468

GO:0007049

GO:0007050

GO:0008150

GO:0010468

GO:0010494

GO:0010526

GO:0015031

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0030427

GO:0032196

GO:0035556

GO:0042221

GO:0042597

GO:0042802

GO:0043167

GO:0043332

GO:0043409

GO:0043934

GO:0043935

GO:0046777

GO:0046827

GO:0051049

GO:0051169

GO:0051301

GO:0051321

GO:0071507

GO:0106310

Participates

as an input of

ERK5 translocates to the nucleus (Saccharomyces cerevisiae)

Other forms of this molecule

ub-MAPK6 [cytosol]

MAPK4 [nucleoplasm]

MAPK4 [cytosol]

MAPK6 [cytosol]

phospho-p-S189 MAPK6 [cytosol]

phospho-p-S186 MAPK4 [cytosol]

phospho-p-S186 MAPK4 [nucleoplasm]

phospho-p-S189 MAPK6 [nucleoplasm]

MAPK6 [nucleoplasm]

phospho-p-3S,T MAPK6 [nucleoplasm]

phospho-p-T185,Y187-MAPK1 [nucleoplasm]

phospho-p-T202,Y204-MAPK3 [nucleoplasm]

phospho-p-T202,Y204-MAPK3 [cytosol]

phospho-p-T185,Y187-MAPK1 [cytosol]

MAPK1 [cytosol]

MAPK3 [cytosol]

phospho-p-T218,Y221-MAPK7 [nucleoplasm]

MAPK7 [nucleoplasm]

MAPK3 [nucleoplasm]

MAPK1 [nucleoplasm]

phospho-p-T185-MAPK1 [cytosol]

phospho-p-T202-MAPK3 [cytosol]

phospho-p-T298-NLK [cytosol]

phospho-p-T298-NLK [nucleoplasm]

NLK [cytosol]

MAPK1 [ficolin-1-rich granule lumen]

MAPK1 [extracellular region]

MAPK1 [azurophil granule lumen]

Inferred From

p-T218,Y221-MAPK7 [cytosol] (Homo sapiens)

Modified Residues

Name

O-phospho-L-threonine at 219 (in Homo sapiens)

Coordinate

219

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O4'-phospho-L-tyrosine at 221 (in Homo sapiens)

Coordinate

221

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_009537.1

PRO

P16892

PDB

2B9F, 2FA2, 2B9I, 2B9H, 2F49, 2F9G, 2B9J

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06784	7	phospho-p-S,218, S222,T292 MAP2K1 [cytosol] (R-SCE-5674490) phospho-p-S,T-MAP2K2 [cytosol] (R-SCE-109848) phospho-p-T286,T292-MAP2K1 [cytosol] (R-SCE-112374) phospho-p-S218,S222,T286,T292-MAP2K1 [cytosol] (R-SCE-112339) MAP2K1 [cytosol] (R-SCE-59502) phospho-p-S222,S226-MAP2K2 [cytosol] (R-SCE-169292) phospho-p-S218,S222-MAP2K1 [cytosol] (R-SCE-109837)	0.932	15
UniProt:P32917 STE5			0.91	11
UniProt:P23561	1	MAP3K5 [cytosol] (R-SCE-167709)	0.721	6
UniProt:P16892	20	ub-MAPK6 [cytosol] (R-SCE-5687000-2) MAPK4 [nucleoplasm] (R-SCE-5686975-2) MAPK4 [cytosol] (R-SCE-5686973-2) MAPK6 [cytosol] (R-SCE-5686979-2) phospho-p-S189 MAPK6 [cytosol] (R-SCE-5687019-2) phospho-p-S186 MAPK4 [cytosol] (R-SCE-5687023-2) phospho-p-S186 MAPK4 [nucleoplasm] (R-SCE-5687022-2) phospho-p-S189 MAPK6 [nucleoplasm] (R-SCE-5687015-2) MAPK6 [nucleoplasm] (R-SCE-5692686-2) phospho-p-3S,T MAPK6 [nucleoplasm] (R-SCE-5692665-2) phospho-p-T185,Y187-MAPK1 [nucleoplasm] (R-SCE-112354-2) phospho-p-T202,Y204-MAPK3 [nucleoplasm] (R-SCE-112359-2) phospho-p-T202,Y204-MAPK3 [cytosol] (R-SCE-109842-2) phospho-p-T185,Y187-MAPK1 [cytosol] (R-SCE-109853-2) MAPK1 [cytosol] (R-SCE-59282-2) MAPK3 [cytosol] (R-SCE-59284-2) phospho-p-T218,Y221-MAPK7 [nucleoplasm] (R-SCE-198738) phospho-p-T218,Y221-MAPK7 [cytosol] (R-SCE-198721) MAPK7 [nucleoplasm] (R-SCE-199961) MAPK3 [nucleoplasm] (R-SCE-73724-2)	0.592	2
UniProt:P14681	20	ub-MAPK6 [cytosol] (R-SCE-5687000) phospho-p-T185,Y187-MAPK1 [nucleoplasm] (R-SCE-112354) phospho-p-T202,Y204-MAPK3 [nucleoplasm] (R-SCE-112359) phospho-p-T202,Y204-MAPK3 [cytosol] (R-SCE-109842) phospho-p-T185,Y187-MAPK1 [cytosol] (R-SCE-109853) MAPK1 [cytosol] (R-SCE-59282) MAPK3 [cytosol] (R-SCE-59284) MAPK3 [nucleoplasm] (R-SCE-73724) MAPK1 [nucleoplasm] (R-SCE-199960) phospho-p-T185-MAPK1 [cytosol] (R-SCE-9635773) phospho-p-T202-MAPK3 [cytosol] (R-SCE-9635775) phospho-p-T298-NLK [cytosol] (R-SCE-4411398) phospho-p-T298-NLK [nucleoplasm] (R-SCE-4411376) NLK [cytosol] (R-SCE-4411330) MAPK1 [ficolin-1-rich granule lumen] (R-SCE-6800964) MAPK1 [extracellular region] (R-SCE-6806250) MAPK1 [azurophil granule lumen] (R-SCE-6799225) phospho-p-3S,T MAPK6 [nucleoplasm] (R-SCE-5692665) MAPK6 [nucleoplasm] (R-SCE-5692686) phospho-p-S189 MAPK6 [nucleoplasm] (R-SCE-5687015)	0.573	2
UniProt:Q12329 HSP42			0.564	2
UniProt:P19882 HSP60	7	HSP60 [mitochondrial matrix] (R-SCE-1252181) HSP60 [mitochondrial matrix] (R-SCE-1299448) HSP60 [mitochondrial inner membrane] (R-SCE-1267982) HSP60 precursor [mitochondrial inner membrane] (R-SCE-1267967) HSP60 precursor [mitochondrial intermembrane space] (R-SCE-1252158) HSP60 [cytosol] (R-SCE-1252153) HSP60 [mitochondrial matrix] (R-SCE-8986171)	0.564	2
UniProt:P15992 HSP26			0.564	2
UniProt:Q03063 DIG1			0.547	2
UniProt:Q03373 DIG2			0.547	2
UniProt:P08539	5	GNA13 [plasma membrane] (R-SCE-167451) GNAL [plasma membrane] (R-SCE-170657) GNA14 [plasma membrane] (R-SCE-167453) GNA15 [plasma membrane] (R-SCE-167450) GNA11 [plasma membrane] (R-SCE-167446)	0.544	2
UniProt:P33306 BCK2			0.499	2

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