Reactome | PKLR-2 [cytosol]

PKLR-2 [cytosol]

Stable Identifier

R-SCE-211388

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

P00549

Locations in the PathwayBrowser

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Metabolism (Saccharomyces cerevisiae)

- Aerobic respiration and respiratory electron transport (Saccharomyces cerevisiae)
  - Pyruvate metabolism (Saccharomyces cerevisiae)
    - PKM dephosphorylates PEP to PYR (Saccharomyces cerevisiae)
      - pyruvate kinase tetramer [cytosol] (Saccharomyces cerevisiae)
        
        pyruvate kinase complex, liver and RBC [cytosol] (Saccharomyces cerevisiae)
        
        PKLR-2 [cytosol] (Saccharomyces cerevisiae)
- Metabolism of carbohydrates and carbohydrate derivatives (Saccharomyces cerevisiae)
  - Glucose metabolism (Saccharomyces cerevisiae)
    - Glycolysis (Saccharomyces cerevisiae)
      - PKM dephosphorylates PEP to PYR (Saccharomyces cerevisiae)
        
        pyruvate kinase tetramer [cytosol] (Saccharomyces cerevisiae)
        
        pyruvate kinase complex, liver and RBC [cytosol] (Saccharomyces cerevisiae)
        
        PKLR-2 [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P00549

Reference Genes

BioGPS Gene:851193

ENSEMBL:YAL038W

KEGG:sce:YAL038W

Monarch:851193

NCBI Entrez Gene:851193

SGD:YAL038W

UCSC:P00549

Reference Transcript

RefSeq:NM_001178183.1

Other Identifiers

851193

GO:0000166

GO:0000287

GO:0003674

GO:0003824

GO:0004743

GO:0005524

GO:0005737

GO:0005886

GO:0006090

GO:0006091

GO:0006096

GO:0016301

GO:0016740

GO:0030955

GO:0032787

GO:0043167

GO:0046872

GO:0055086

Participates

as a component of

pyruvate kinase complex, liver and RBC [cytosol] (Saccharomyces cerevisiae)

Other forms of this molecule

PKM [ficolin-1-rich granule lumen]

PKM [extracellular region]

PKM [secretory granule lumen]

PolyUb-PKM-1 [cytosol]

PKM-2 [cytosol]

PKM [nucleoplasm]

Inferred From

Pyruvate kinase, R/L type [cytosol] (Homo sapiens)

PKLR-2 [cytosol] (Homo sapiens)

PKLR-1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_009362.1

ENSEMBL

YAL038W, YAL038W, YAL038W_mRNA

IntEnz

2.7.1.40

PRO

P00549

PDB

1A3X, 1A3W

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P25491	3	SOH-C149,C150-DNAJA1 [cytosol] (R-SCE-9857072) DNAJA4 [cytosol] (R-SCE-3371578) DNAJA2 [cytosol] (R-SCE-3371555)	0.527	2
UniProt:P02829	11	HSP90AA1 [cytosol] (R-SCE-192864) HSP90AB1 [nucleoplasm] (R-SCE-5082399) HSP90AA1 [nucleoplasm] (R-SCE-5082401) HSP90AB1 [cytosol] (R-SCE-419617) HSP90AA1 [plasma membrane] (R-SCE-534996) HSP90AA1 [extracellular region] (R-SCE-3221946) HSP90AA1 [secretory granule lumen] (R-SCE-6801515) HSP90AB1 [secretory granule lumen] (R-SCE-6801477) HSP90AB1 [extracellular region] (R-SCE-6806463) HSP90AA1 [ficolin-1-rich granule lumen] (R-SCE-6801470) HSP90AB1 [ficolin-1-rich granule lumen] (R-SCE-6801491)	0.527	2
UniProt:P10592	20	SSA2 [cytosol] (R-SCE-264476) SSA2 [nucleoplasm] (R-SCE-5082380) SSA2 [cytosol] (R-SCE-3371410-3) SSA2 [cytosol] (R-SCE-3371408-3) SSA2 [cytosol] (R-SCE-6792602-3) SSA2 [secretory granule lumen] (R-SCE-6801530) SSA2 [secretory granule lumen] (R-SCE-6801472-3) SSA2 [extracellular region] (R-SCE-6806500-3) SSA2 [extracellular region] (R-SCE-6805936) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801496-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801512-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801494) SSA2 [extracellular region] (R-SCE-6805872-3) SSA2 [nucleoplasm] (R-SCE-6792605-3) SSA2 [nucleoplasm] (R-SCE-912480-3) SSA2 [nucleoplasm] (R-SCE-5082367-3) SSA2 [nucleoplasm] (R-SCE-5252082-3) SSA2 [nucleoplasm] (R-SCE-5252088-3) SSA2 [nucleoplasm] (R-SCE-5252009-3) SSA2 [cytosol] (R-SCE-5251948-3)	0.527	2
UniProt:Q01477	2	UBP3 [nucleoplasm] (R-SCE-3222218) UBP3 [cytosol] (R-SCE-6782974)	0.527	2

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