HHB is hydroxylated to DHHB by Coq6

Stable Identifier
R-SCE-2162292
Type
Reaction [transition]
Species
Saccharomyces cerevisiae
Compartment
General
SVG |   | PPTX  | SBGN
HHB is hydroxylated to DHHB by Coq6

A flavin-dependent monooxygenase involved in ubiquinone/ubiquinol biosynthesis, Coq6 (Heeringa et al. 2011) catalyses the C5-hydroxylation of 3-hexaprenyl-4-hydroxybenzoic acid (HHB) to 3,4-dihydroxy-5-hexaprenylbenzoic acid (DHHB) (Ozeir et al. 2011, Gin et al. 2003). Coq6 is a peripheral membrane protein that localizes to the matrix side of the inner mitochondrial membrane (Gin et al. 2003). Ferredoxin, Yah1 and the ferredoxin reductase, Arh1 may be the in vivo source of electrons for Coq6 and additionally required for this reaction (Ozeir et al. 2011).

Literature References
PubMed ID Title Journal Year
21944752 Coenzyme Q biosynthesis: Coq6 is required for the C5-hydroxylation reaction and substrate analogs rescue Coq6 deficiency

Ozeir, M, Mühlenhoff, U, Webert, H, Lill, R, Fontecave, M, Pierrel, F

Chem Biol 2011
12721307 The Saccharomyces cerevisiae COQ6 gene encodes a mitochondrial flavin-dependent monooxygenase required for coenzyme Q biosynthesis

Gin, P, Hsu, AY, Rothman, SC, Jonassen, T, Lee, PT, Tzagoloff, A, Clarke, CF

J Biol Chem 2003
Participants
Catalyst Activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen of Coq6:FAD [mitochondrial inner membrane]

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