HMPhOH is hydroxylated to MDMQ6H2 by HMPhOH monooxygenase

Stable Identifier
R-SCE-2164813
Type
Reaction [omitted]
Species
Saccharomyces cerevisiae
Compartment
General
SVG |   | PPTX  | SBGN
HMPhOH is hydroxylated to MDMQ6H2 by HMPhOH monooxygenase

2-hexaprenyl-6-methoxyphenol (HMPhOH) aka 2-methoxy-6-hexaprenylphenol is enzymatically converted to 2-hexaprenyl-6-methoxy-1,4-benzoquinol (MDMQ6H2) (Gin et al. 2003, Ozeir et al. 2011). It was thought at one time that the flavin-dependent monooxygenase, Coq6, was the enzyme that catalysed this reaction, however, it has been subsequently shown that Coq6 is not essential for this reaction (Ozeir et al. 2011). However, it is still believed that another member of the Coq family catalyses this event.

Literature References
PubMed ID Title Journal Year
21944752 Coenzyme Q biosynthesis: Coq6 is required for the C5-hydroxylation reaction and substrate analogs rescue Coq6 deficiency

Ozeir, M, Mühlenhoff, U, Webert, H, Lill, R, Fontecave, M, Pierrel, F

Chem Biol 2011
12721307 The Saccharomyces cerevisiae COQ6 gene encodes a mitochondrial flavin-dependent monooxygenase required for coenzyme Q biosynthesis

Gin, P, Hsu, AY, Rothman, SC, Jonassen, T, Lee, PT, Tzagoloff, A, Clarke, CF

J Biol Chem 2003
Participants
Catalyst Activity

monooxygenase activity of HMPhOH monooxygenase [mitochondrial matrix]

Orthologous Events
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