Reactome | HSPA2 [cytosol]

HSPA2 [cytosol]

Stable Identifier

R-SCE-3371408-4

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

P11484

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Saccharomyces cerevisiae)

- Cellular responses to stress (Saccharomyces cerevisiae)
  - HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Saccharomyces cerevisiae)
    - ATP binding to HSP90 triggers conformation change (Saccharomyces cerevisiae)
      - HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Saccharomyces cerevisiae)
        
        HSP70:ADP [cytosol] (Saccharomyces cerevisiae)
        
        HSP70 proteins [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of HSPA2 [cytosol] (Saccharomyces cerevisiae)
        
        HSPA2 [cytosol] (Saccharomyces cerevisiae)
      - HSP90:STIP1:HSP70:nascent protein [cytosol] (Saccharomyces cerevisiae)
        
        HSP70:ADP:nascent protein [cytosol] (Saccharomyces cerevisiae)
        
        HSP70:ADP [cytosol] (Saccharomyces cerevisiae)
        
        HSP70 proteins [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of HSPA2 [cytosol] (Saccharomyces cerevisiae)
        
        HSPA2 [cytosol] (Saccharomyces cerevisiae)
    - ATP hydrolysis by HSP70 (Saccharomyces cerevisiae)
      - HSP40:HSP70:ADP:nascent protein [cytosol] (Saccharomyces cerevisiae)
        
        HSP70 proteins [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of HSPA2 [cytosol] (Saccharomyces cerevisiae)
        
        HSPA2 [cytosol] (Saccharomyces cerevisiae)
      - HSP40:HSP70:ATP:nascent protein [cytosol] (Saccharomyces cerevisiae)
        
        HSP70 proteins [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of HSPA2 [cytosol] (Saccharomyces cerevisiae)
        
        HSPA2 [cytosol] (Saccharomyces cerevisiae)
      - HSP70 proteins [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of HSPA2 [cytosol] (Saccharomyces cerevisiae)
        
        HSPA2 [cytosol] (Saccharomyces cerevisiae)
    - HSP70 binds to HSP40:nascent protein (Saccharomyces cerevisiae)
      - HSP40:HSP70:ATP:nascent protein [cytosol] (Saccharomyces cerevisiae)
        
        HSP70 proteins [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of HSPA2 [cytosol] (Saccharomyces cerevisiae)
        
        HSPA2 [cytosol] (Saccharomyces cerevisiae)
      - HSP70:ATP [cytosol] (Saccharomyces cerevisiae)
        
        HSP70 proteins [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of HSPA2 [cytosol] (Saccharomyces cerevisiae)
        
        HSPA2 [cytosol] (Saccharomyces cerevisiae)
    - STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Saccharomyces cerevisiae)
      - HSP40:HSP70:ADP:nascent protein [cytosol] (Saccharomyces cerevisiae)
        
        HSP70 proteins [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of HSPA2 [cytosol] (Saccharomyces cerevisiae)
        
        HSPA2 [cytosol] (Saccharomyces cerevisiae)
      - HSP90:STIP1:HSP70:nascent protein [cytosol] (Saccharomyces cerevisiae)
        
        HSP70:ADP:nascent protein [cytosol] (Saccharomyces cerevisiae)
        
        HSP70:ADP [cytosol] (Saccharomyces cerevisiae)
        
        HSP70 proteins [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of HSPA2 [cytosol] (Saccharomyces cerevisiae)
        
        HSPA2 [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P11484

Reference Genes

BioGPS Gene:851369

ENSEMBL:YDL229W

KEGG Gene (Saccharomyces cerevisiae (strain YJM789)):YDL229W

Monarch:851369

NCBI Gene:851369

SGD:YDL229W

Reference Transcript

RefSeq:NM_001180289.1

Other Identifiers

1770173_at

1770884_s_at

851369

9094_s_at

GO:0000054

GO:0000166

GO:0002181

GO:0003674

GO:0005515

GO:0005516

GO:0005524

GO:0005575

GO:0005737

GO:0005844

GO:0005886

GO:0006364

GO:0006412

GO:0006414

GO:0006415

GO:0006450

GO:0006452

GO:0006457

GO:0008150

GO:0016020

GO:0016787

GO:0016887

GO:0031072

GO:0034620

GO:0042026

GO:0042149

GO:0042221

GO:0042594

GO:0043167

GO:0044183

GO:0051082

GO:0051083

GO:0051085

GO:0051169

GO:0051787

GO:0140657

GO:0140662

Participates

as a member of

Homologues of HSPA2 [cytosol] (Saccharomyces cerevisiae)

Other forms of this molecule

HSPA2 [nucleoplasm]

Inferred From

HSPA2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_010052.1

PRO

P11484

PDB

3GL1

Interactors (60)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07260	1	CDC33 [cytosol] (R-SCE-72578)	0.643	3
UniProt:P30822	1	CRM1 [nucleoplasm] (R-SCE-165529)	0.643	3
UniProt:P02829	11	HSP90AA1 [secretory granule lumen] (R-SCE-6801515) HSP90AB1 [secretory granule lumen] (R-SCE-6801477) HSP90AB1 [extracellular region] (R-SCE-6806463) HSP90AA1 [extracellular region] (R-SCE-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-SCE-6801470) HSP90AB1 [ficolin-1-rich granule lumen] (R-SCE-6801491) HSP90AA1 [plasma membrane] (R-SCE-534996) HSP90AB1 [cytosol] (R-SCE-419617) HSP90AA1 [nucleoplasm] (R-SCE-5082401) HSP90AB1 [nucleoplasm] (R-SCE-5082399) HSP90AA1 [cytosol] (R-SCE-192864)	0.564	3
UniProt:P29469 MCM2	2	MCM2 [nucleoplasm] (R-SCE-68557) yMcm2 [nucleoplasm] (R-SCE-169497)	0.564	2
UniProt:P48365	2	GYP7 [cytosol] (R-SCE-8854150) GYP7 [autophagosome] (R-SCE-8854607)	0.527	2
UniProt:P25357	2	SNT1 [nucleoplasm] (R-SCE-442469) SNT1 [nucleoplasm] (R-SCE-442501)	0.527	2
UniProt:Q08920	2	NCBP2 [cytosol] (R-SCE-162458) NCBP2 [nucleoplasm] (R-SCE-51463)	0.527	2
UniProt:P15303	4	phospho-p-S742,T747 SEC23A [cytosol] (R-SCE-5685740) SEC23A [ER to Golgi transport vesicle membrane] (R-SCE-204024) SEC23A [cytosol] (R-SCE-203972) SEC23A [endoplasmic reticulum membrane] (R-SCE-203976)	0.527	2
UniProt:Q00955	6	phospho-Btn-p-S79-ACACB [mitochondrial outer membrane] (R-SCE-8876892-2) ACACB [cytosol] (R-SCE-52493-2) ACACA [cytosol] (R-SCE-1660609) Btn-ACACA [cytosol] (R-SCE-2976730) ACACB [mitochondrial outer membrane] (R-SCE-4167505-2) Btn-ACACB [mitochondrial outer membrane] (R-SCE-2993858-2)	0.527	2
UniProt:Q06142	4	KAP95 [specific granule lumen] (R-SCE-6799646) KAP95 [extracellular region] (R-SCE-6806306) KAP95 [ficolin-1-rich granule lumen] (R-SCE-6800978) KAP95 [cytosol] (R-SCE-180733)	0.527	3
UniProt:P40344	8	ATG3 [cytosol] (R-SCE-5671860) CysO264-ATG3-MAP1LC3A [cytosol] (R-SCE-9819371) CysO264-ATG3-GABARAP [cytosol] (R-SCE-9819379) CysO264-ATG3-GABARAPL2 [cytosol] (R-SCE-9819376) CysO264-ATG3-MAP1LC3C [cytosol] (R-SCE-9819377) CysO264-ATG3-GABARAPL1 [cytosol] (R-SCE-9819381) CysO264-ATG3-MAP1LC3B [cytosol] (R-SCE-9819365) CysO264-ATG3-GABARAPL3 [cytosol] (R-SCE-5683569)	0.527	2
UniProt:P53730	1	ALG12 [endoplasmic reticulum membrane] (R-SCE-449348)	0.527	2
UniProt:P34216	2	ITSN2 [cytosol] (R-SCE-8862264) ITSN1 [cytosol] (R-SCE-3006481)	0.527	2
UniProt:P06700	1	SIRT1 [nucleoplasm] (R-SCE-427531)	0.527	2
UniProt:P06778	3	RAD52 [nucleoplasm] (R-SCE-4568909) RAD52 [nucleoplasm] (R-SCE-62639) phospho-RAD52 [nucleoplasm] (R-SCE-5686588)	0.527	3
UniProt:P28817	1	HIBCH [mitochondrial matrix] (R-SCE-70872)	0.527	2
UniProt:P39108	2	PEX7 [peroxisomal membrane] (R-SCE-9033493) PEX7 [cytosol] (R-SCE-9033107)	0.527	2
UniProt:Q03957	4	CDK13 [nucleoplasm] (R-SCE-6797014) CDK12 [nucleoplasm] (R-SCE-6797012) CDK13 [extracellular region] (R-SCE-6806442) CDK13 [ficolin-1-rich granule lumen] (R-SCE-6801374)	0.527	2
UniProt:Q03834	1	MSH6 [nucleoplasm] (R-SCE-5357528)	0.527	3
UniProt:P32775	1	GLC3 [cytosol] (R-SCE-71576)	0.527	3
UniProt:Q04958	1	PNPLA6 [endoplasmic reticulum membrane] (R-SCE-1498821)	0.527	2
UniProt:P54861	2	DNM1L [mitochondrial outer membrane] (R-SCE-351942) DNM1L [cytosol] (R-SCE-351943)	0.527	3
UniProt:P25037	2	UBP1 [mitochondrial outer membrane] (R-SCE-5696931) UBP1 [peroxisomal membrane] (R-SCE-9674135)	0.527	3
UniProt:P11746	2	phospho-MCM1 [nucleoplasm] (R-SCE-9612518) MCM1 [nucleoplasm] (R-SCE-5666000)	0.527	2
UniProt:Q99190	2	TSC13 [endoplasmic reticulum membrane] (R-SCE-548663) TSC13 [endoplasmic reticulum membrane] (R-SCE-4127427)	0.527	3
UniProt:P29547	1	CAM1 [cytosol] (R-SCE-156925)	0.527	3
UniProt:P29496 MCM5	2	MCM5 [nucleoplasm] (R-SCE-68551) yMcm5 [nucleoplasm] (R-SCE-169511)	0.527	3
UniProt:P43565	1	phospho-p-T194,T207,T741-MASTL [nucleoplasm] (R-SCE-2430549)	0.527	3
UniProt:P38217	1	KAP104 [cytosol] (R-SCE-180743)	0.527	2
UniProt:P32567	9	phospho-PAH1 [nucleoplasm] (R-SCE-4419936) phospho-PAH1 [nucleoplasm] (R-SCE-4419933) phospho-PAH1 [nucleoplasm] (R-SCE-4419935) PAH1 [nuclear envelope] (R-SCE-4419927) PAH1 [nuclear envelope] (R-SCE-4419928) PAH1 [nuclear envelope] (R-SCE-4419926) PAH1 [endoplasmic reticulum membrane] (R-SCE-549157) PAH1 [endoplasmic reticulum membrane] (R-SCE-549160) PAH1 [endoplasmic reticulum membrane] (R-SCE-549165)	0.527	2
UniProt:P00546	8	phospho-p-T160-CDK2 [nucleoplasm] (R-SCE-187967) CDK2 [nucleoplasm] (R-SCE-68365) CDK2 [cytosol] (R-SCE-157440) CDK6 [nucleoplasm] (R-SCE-141283) CDK4 [nucleoplasm] (R-SCE-113843) CDK6 [cytosol] (R-SCE-68336) CDK4 [cytosol] (R-SCE-68330) phospho-p-CDK2 [nucleoplasm] (R-SCE-68370)	0.527	3
UniProt:P35845	3	OSBP [cytosol] (R-SCE-429725) OSBPL1A [cytosol] (R-SCE-2213214) OSBPL2 [cytosol] (R-SCE-8867527)	0.527	2
UniProt:P43558	1	YOD1 [cytosol] (R-SCE-6781909)	0.527	2
UniProt:Q03497	12	PAK7 [plasma membrane] (R-SCE-211555-2) PAK1 [plasma membrane] (R-SCE-3928409) phospho-p-S144,T423-PAK1 [plasma membrane] (R-SCE-3928472) PAK5 [cytosol] (R-SCE-428459-2) PAK4 [cytosol] (R-SCE-428461-2) PAK6 [cytosol] (R-SCE-428454-2) phospho-p-S154,T436-PAK3 [cytosol] (R-SCE-5357471) PAK3 [cytosol] (R-SCE-428457) PAK1 [cytosol] (R-SCE-162629) PAK2 [cytosol] (R-SCE-211604-2) phospho-p-S144,T423-PAK1 [cytosol] (R-SCE-399819) phospho-p-S141,T402-PAK2 [cytosol] (R-SCE-399824-2)	0.527	3
UniProt:P53550	1	DCP2 [cytosol] (R-SCE-429937)	0.527	3
UniProt:Q08647 PUS7	1	PUS7 [nucleoplasm] (R-SCE-6786522)	0.527	2
UniProt:P53858	2	BNI4 [plasma membrane] (R-SCE-8848883) BNI4 [platelet alpha granule membrane] (R-SCE-8848893)	0.527	2
UniProt:P25454	2	RAD51 [nucleoplasm] (R-SCE-62637) phospho-p-T309-RAD51 [nucleoplasm] (R-SCE-5685231)	0.527	2
UniProt:Q08444	2	NOB1 [nucleoplasm] (R-SCE-6791536) NOB1 [cytosol] (R-SCE-6791524)	0.527	2
UniProt:P54839	2	ERG13 [cytosol] (R-SCE-191329) ERG13 [mitochondrial matrix] (R-SCE-56573)	0.527	2
UniProt:Q03529	1	FA2H [endoplasmic reticulum membrane] (R-SCE-5693771)	0.527	2
UniProt:P06786	4	monoSUMO1-K-TOP2B [nucleoplasm] (R-SCE-4641297) TOP2B [nucleoplasm] (R-SCE-4641359) monoSUMO1-K-TOP2A [nucleoplasm] (R-SCE-4641367) TOP2A [nucleoplasm] (R-SCE-1362276)	0.527	3
UniProt:P02309	13	HHF2 [nucleoplasm] (R-SCE-4570518) HHF2 [nucleoplasm] (R-SCE-212078) HHF2 [nucleoplasm] (R-SCE-427469) HHF2 [nucleoplasm] (R-SCE-4568748) HHF2 [nucleoplasm] (R-SCE-4568758) HHF2 [nucleoplasm] (R-SCE-5229015) HHF2 [nucleoplasm] (R-SCE-4754243) HHF2 [nucleoplasm] (R-SCE-4754240) HHF2 [nucleoplasm] (R-SCE-5651656) HHF2 [nucleoplasm] (R-SCE-5423110) HHF2 [nucleoplasm] (R-SCE-3451124) HHF2 [nucleoplasm] (R-SCE-181902) HHF2 [nucleoplasm] (R-SCE-5651652)	0.527	3
UniProt:P32833 ORC2	2	yORC2 [nucleoplasm] (R-SCE-9749316) ORC2 [nucleoplasm] (R-SCE-68405)	0.527	2
UniProt:Q06245	1	SEC10 [cytosol] (R-SCE-265045)	0.527	2
UniProt:P22147 XRN1	2	XRN1_YEAST [cytosol] (R-SCE-429980) XRN1 [cytosol] (R-SCE-429835)	0.527	2
UniProt:P33322	1	CBF5 [nucleoplasm] (R-SCE-163102)	0.527	2
UniProt:Q06682	2	UBX5 [cytosol] (R-SCE-9755305) UBX5 [cytosol] (R-SCE-8956071)	0.527	2
UniProt:P23561	1	MAP3K5 [cytosol] (R-SCE-167709)	0.527	2
UniProt:Q99247	1	DUF1 [nucleoplasm] (R-SCE-419549)	0.527	2
UniProt:Q07381	2	TSR1 [cytosol] (R-SCE-6791570) TSR1 [nucleoplasm] (R-SCE-6791574)	0.527	2
UniProt:P54784 ORC1	6	phospho-PolyUb,p-S,T-ORC1 [cytosol] (R-SCE-9032195) phospho-PolyUb,p-S,T-ORC1 [nucleoplasm] (R-SCE-9032189) phospho-p-S,T-ORC1 [nucleoplasm] (R-SCE-68943) ORC1 [cytosol] (R-SCE-113840) yORC1 [nucleoplasm] (R-SCE-9749323) ORC1 [nucleoplasm] (R-SCE-68522)	0.527	2
UniProt:Q08972	1	ABCF1 [cytosol] (R-SCE-5216139)	0.527	3
UniProt:P32447	1	ASF1 [nucleoplasm] (R-SCE-417169)	0.527	3
UniProt:P24783	4	monoSUMO1-K50-DDX17 [nucleoplasm] (R-SCE-3900104) DDX17 [nucleoplasm] (R-SCE-3900090) monoSUMO1-K53-DDX5 [nucleoplasm] (R-SCE-3900041) DDX5 [nucleoplasm] (R-SCE-3900136)	0.527	3
UniProt:P04819	1	LIG1 [nucleoplasm] (R-SCE-53787)	0.527	2
UniProt:P38205 NCL1	1	NCL1 [nucleoplasm] (R-SCE-6790210)	0.527	2
UniProt:P25847	1	MSH2 [nucleoplasm] (R-SCE-5357525)	0.527	2
UniProt:P32525	2	ECM25 [cytosol] (R-SCE-2976577) ECM25 [cytosol] (R-SCE-195193)	0.527	2
UniProt:Q12505	3	CHEK1 [cytosol] (R-SCE-205285) CHEK1 [nucleoplasm] (R-SCE-113826) phospho-p-S317,S345-CHEK1 [nucleoplasm] (R-SCE-113838)	0.527	2

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