Reactome | SMT3 [nucleoplasm]

SMT3 [nucleoplasm]

Stable Identifier

R-SCE-3730622

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

nucleoplasm

Synonyms

UBE2I-G97-SUMO1, Q12306

Locations in the PathwayBrowser

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DNA Repair (Saccharomyces cerevisiae)

- DNA Double-Strand Break Repair (Saccharomyces cerevisiae)
  - DNA Double Strand Break Response (Saccharomyces cerevisiae)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Saccharomyces cerevisiae)
      - PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Saccharomyces cerevisiae)
        
        SUMO1:C93-UBE2I [nucleoplasm] (Saccharomyces cerevisiae)
        
        SMT3 [nucleoplasm] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:Q12306

Gene Names

SMT3

Reference Genes

BioGPS Gene:852122 SMT3

ENSEMBL:YDR510W

KEGG:sce:YDR510W SMT3

Monarch:852122 SMT3

NCBI Gene:852122 SMT3

SGD:YDR510W

UCSC:Q12306 SMT3

Reference Transcript

RefSeq:NM_001180818.1 SMT3

Other Identifiers

1776081_at

5979_at

852122

GO:0000794

GO:0003674

GO:0005515

GO:0005575

GO:0005634

GO:0005694

GO:0005737

GO:0005856

GO:0005938

GO:0005940

GO:0008150

GO:0016925

GO:0018193

GO:0019899

GO:0031386

GO:0042802

GO:0044389

GO:0070647

Participates

as a component of

SUMO1:C93-UBE2I [nucleoplasm] (Saccharomyces cerevisiae)

Other forms of this molecule

SMT3 [nucleoplasm]

SMT3 [cytosol]

Inferred From

UBE2I-G97-SUMO1 [nucleoplasm] (Homo sapiens)

Modified Residues

Name

Inter-chain Crosslink via S-(glycyl)-L-cysteine (Cys-Gly) at 97 and 93 (in Homo sapiens)

Coordinate

PsiMod Name

S-(glycyl)-L-cysteine (Cys-Gly)

PsiMod Definition

A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.

Cross References

RefSeq

NP_010798.1

ENSEMBL

YDR510W_mRNA

PRO

Q12306

PDB

6P81, 7ZHS, 6CFP, 6RPQ, 5YCA, 3PGE, 6O4A, 7P7I, 3UF8, 7P7W, 7P47, 6UKM, 8UZH, 6UKW, 3UQA, 7ZWL, 3UQB, 6VEL, 6UKY, 6UKZ, 5V8T, 4G50, 3TIX, 2EKE, 3VAW, 8B7F, 6Q2S, 1EUV, 7PA1, 5KLX, 3V62, 8R1F, 8R1G, 8DMB, 7O2W, 7LTO, 5JNE, 4FN2, 4GIV, 6UKU, 4GGQ, 6UL0, 3QHT, 6UKV, 5YC2, 6VW2, 6UKX, 7P9L, 6O49, 7P9P, 7P9Y, 1L2N, 3V60, 7SDE, 5D6J, 3V61

Interactors (33)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P50623	5	UBC9 [nucleoplasm] (R-SCE-4085358) UBC9 [cytosol] (R-SCE-4656944) UBC9 [cytosol] (R-SCE-4656909) UBC9 [nucleoplasm] (R-SCE-3730617) UBC9 [nucleoplasm] (R-SCE-912481)	0.757	4
UniProt:Q08204	1	SMC5 [nucleoplasm] (R-SCE-2993751)	0.728	5
UniProt:P12954 SRS2			0.704	4
UniProt:P14291 RED1			0.704	9
UniProt:P15873	5	POL30 [nucleoplasm] (R-SCE-68439) POL30 [nucleoplasm] (R-SCE-5651986) POL30 [nucleoplasm] (R-SCE-5653768) POL30 [nucleoplasm] (R-SCE-8943000) POL30 [nucleoplasm] (R-SCE-4615861)	0.698	6
UniProt:Q12050 ELG1			0.683	11
UniProt:Q12306	5	SMT3 [nucleoplasm] (R-SCE-2990831) SMT3 [nucleoplasm] (R-SCE-877304) SMT3 [nucleoplasm] (R-SCE-3730616) SMT3 [nucleoplasm] (R-SCE-3730622) SMT3 [cytosol] (R-SCE-4656941)	0.681	3
UniProt:P06778	3	RAD52 [nucleoplasm] (R-SCE-4568909) RAD52 [nucleoplasm] (R-SCE-62639) phospho-RAD52 [nucleoplasm] (R-SCE-5686588)	0.589	2
UniProt:P25694	7	VCP [cytosol] (R-SCE-1181251) VCP [secretory granule lumen] (R-SCE-6801039) VCP [extracellular region] (R-SCE-6806191) VCP [azurophil granule lumen] (R-SCE-6800438) VCP [ficolin-1-rich granule lumen] (R-SCE-6800425) VCP [nucleoplasm] (R-SCE-5643745) Me3K315-VCP [cytosol] (R-SCE-8932209)	0.567	3
UniProt:P53044	2	UFD1 [nucleoplasm] (R-SCE-5654993) UFD1 [cytosol] (R-SCE-9668519)	0.567	3
UniProt:P52488	2	SUMO1-C173-UBA2 [nucleoplasm] (R-SCE-3730628) UBA2 [nucleoplasm] (R-SCE-947696)	0.558	2
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [nucleoplasm] (R-HSA-912481) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) UBE2I [cytosol] (R-HSA-4655342)	0.556	3
UniProt:H3BQQ9 H3BQQ9			0.556	3
UniProt:Q9HCK0 ZBT26			0.556	3
UniProt:P23497-2 SP100			0.556	3
UniProt:P32828 SLX5			0.553	2
UniProt:Q04110 ECM11			0.553	2
UniProt:P38319 TYDP1			0.553	2
UniProt:Q03718 NSE5			0.553	2
UniProt:P35187	1	BLM [nucleoplasm] (R-SCE-174881)	0.527	3
UniProt:P53091 MCM6	2	MCM6 [nucleoplasm] (R-SCE-68553) yMcm6 [nucleoplasm] (R-SCE-169504)	0.524	2
UniProt:P30665 MCM4	2	MCM4 [nucleoplasm] (R-SCE-68549) yMcm4 [nucleoplasm] (R-SCE-169496)	0.524	2
UniProt:P29469 MCM2	2	MCM2 [nucleoplasm] (R-SCE-68557) yMcm2 [nucleoplasm] (R-SCE-169497)	0.524	2
UniProt:P24279 MCM3	2	MCM3 [nucleoplasm] (R-SCE-68546) yMcm3 [nucleoplasm] (R-SCE-169513)	0.524	2
UniProt:P38132 MCM7	2	MCM7 [nucleoplasm] (R-SCE-68555) yMcm7 [nucleoplasm] (R-SCE-169505)	0.524	2
UniProt:P32807	4	YKU70 [ficolin-1-rich granule lumen] (R-SCE-6801300) YKU70 [extracellular region] (R-SCE-6806444) YKU70 [secretory granule lumen] (R-SCE-6801312) YKU70 [nucleoplasm] (R-SCE-58272)	0.524	2
UniProt:P29496 MCM5	2	MCM5 [nucleoplasm] (R-SCE-68551) yMcm5 [nucleoplasm] (R-SCE-169511)	0.524	3
UniProt:Q04437	3	YKU80 [extracellular region] (R-SCE-6806530) YKU80 [secretory granule lumen] (R-SCE-6801297) YKU80 [nucleoplasm] (R-SCE-58274)	0.524	2
UniProt:P32797 CDC13			0.524	3
UniProt:P07271 PIF1			0.524	2
UniProt:P31111	5	ZIP1 [cytosol] (R-SCE-1449561-2) ZIP1 [cytosol] (R-SCE-419176-2) ZIP1 [cytosol] (R-SCE-419173-2) ZIP1 [cytosol] (R-SCE-420855-2) ZIP1 [cytosol] (R-SCE-419174-2)	0.502	2
UniProt:P32908	4	SMC1A [cytosol] (R-SCE-2484798) SMC1A [chromosome] (R-SCE-1638774) SMC1A [chromosome, centromeric region] (R-SCE-2466015) SMC1A [nucleoplasm] (R-SCE-64561)	0.499	2
UniProt:P25454	2	RAD51 [nucleoplasm] (R-SCE-62637) phospho-p-T309-RAD51 [nucleoplasm] (R-SCE-5685231)	0.482	2

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