Reactome | Flipping of the N-glycan precursor into the ER lumen

Flipping of the N-glycan precursor into the ER lumen

Stable Identifier

R-SCE-449765

Type

Reaction [transition]

Species

Saccharomyces cerevisiae

Compartment

endoplasmic reticulum membrane, integral component of cytoplasmic side of endoplasmic reticulum membrane, integral component of lumenal side of endoplasmic reticulum membrane

ReviewStatus

5/5

General

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Flipping of the N-glycan precursor into the ER lumen

The precursor of the N-glycan sugar, now in the form of (GlcNAc)2 (Man)5 (PP-Dol), is flipped through the ER membrane, moving it from the cytosolic side into the ER lumen. The exact mechanism of this translocation is not well understood but the protein RFT1 is known to be involved (Helenius J et al, 2002), along with an unknown flippase.

Literature References

PubMed ID	Title	Journal	Year
11807558	Translocation of lipid-linked oligosaccharides across the ER membrane requires Rft1 protein Walter, P, Valvano, MA, Helenius, J, Marolda, CL, Aebi, M, Ng, DT	Nature	2002