Reactome | HTB1 [nucleoplasm]

HTB1 [nucleoplasm]

Stable Identifier

R-SCE-4568624

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

nucleoplasm

Synonyms

AcK7-HIST1H2BA, P02293

Locations in the PathwayBrowser

Expand all

Chromatin organization (Saccharomyces cerevisiae)

- Chromatin modifying enzymes (Saccharomyces cerevisiae)
  - HDACs deacetylate histones (Saccharomyces cerevisiae)
    - HDAC10 deacetylates histone (Saccharomyces cerevisiae)
      - Acetylated core histone octamer [nucleoplasm] (Saccharomyces cerevisiae)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Saccharomyces cerevisiae)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Saccharomyces cerevisiae)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Saccharomyces cerevisiae)
        
        AcK(7,14,17,22)-HIST1H2BA [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of AcK7-HIST1H2BA [nucleoplasm] (Saccharomyces cerevisiae)
        
        HTB1 [nucleoplasm] (Saccharomyces cerevisiae)
    - HDAC1:2-containing complex deacetylate histones (Saccharomyces cerevisiae)
      - Acetylated core histone octamer [nucleoplasm] (Saccharomyces cerevisiae)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Saccharomyces cerevisiae)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Saccharomyces cerevisiae)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Saccharomyces cerevisiae)
        
        AcK(7,14,17,22)-HIST1H2BA [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of AcK7-HIST1H2BA [nucleoplasm] (Saccharomyces cerevisiae)
        
        HTB1 [nucleoplasm] (Saccharomyces cerevisiae)
    - HDAC3 containing complexes deacetylate histone (Saccharomyces cerevisiae)
      - Acetylated core histone octamer [nucleoplasm] (Saccharomyces cerevisiae)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Saccharomyces cerevisiae)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Saccharomyces cerevisiae)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Saccharomyces cerevisiae)
        
        AcK(7,14,17,22)-HIST1H2BA [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of AcK7-HIST1H2BA [nucleoplasm] (Saccharomyces cerevisiae)
        
        HTB1 [nucleoplasm] (Saccharomyces cerevisiae)
    - HDAC8 deacetylates histones (Saccharomyces cerevisiae)
      - Acetylated core histone octamer [nucleoplasm] (Saccharomyces cerevisiae)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Saccharomyces cerevisiae)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Saccharomyces cerevisiae)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Saccharomyces cerevisiae)
        
        AcK(7,14,17,22)-HIST1H2BA [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of AcK7-HIST1H2BA [nucleoplasm] (Saccharomyces cerevisiae)
        
        HTB1 [nucleoplasm] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P02293

Gene Names

HTB1

Reference Genes

BioGPS Gene:851810 HTB1

ENSEMBL:YDR224C

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YDR224C HTB1

Monarch:851810 HTB1

NCBI Gene:851810 HTB1

SGD:YDR224C

Reference Transcript

RefSeq:NM_001180532.3 HTB1

Other Identifiers

1771292_at

6235_at

851810

GO:0000122

GO:0000786

GO:0000788

GO:0003674

GO:0003677

GO:0005198

GO:0005515

GO:0005575

GO:0005634

GO:0005694

GO:0006281

GO:0006301

GO:0006325

GO:0006333

GO:0006355

GO:0006366

GO:0006974

GO:0008150

GO:0030527

GO:0031298

GO:0032991

GO:0046982

Participates

as a member of

Homologues of AcK7-HIST1H2BA [nucleoplasm] (Saccharomyces cerevisiae)

Other forms of this molecule

HTB1 [nucleoplasm]

Inferred From

AcK7-HIST1H2BA [nucleoplasm] (Homo sapiens)

Modified Residues

Name

N6-acetyl-L-lysine at 7 (in Homo sapiens)

Coordinate

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Cross References

RefSeq

NP_010510.3

PRO

P02293

PDB

4M6B, 7K7G, 7ON1, 7SSA, 7K78, 2JSS, 8OW0, 7DLX, 4WNN, 8OW1, 6AE8, 6GEJ, 6QLD, 4KUD, 6GEN, 5BT1

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02309	14	HHF2 [nucleoplasm] (R-SCE-4570518) HHF2 [nucleoplasm] (R-SCE-212078) HHF2 [nucleoplasm] (R-SCE-4568744) HHF2 [nucleoplasm] (R-SCE-5229015) HHF2 [nucleoplasm] (R-SCE-4754243) HHF2 [nucleoplasm] (R-SCE-4754240) HHF2 [nucleoplasm] (R-SCE-5651656) HHF2 [nucleoplasm] (R-SCE-427469) HHF2 [nucleoplasm] (R-SCE-4568748) HHF2 [nucleoplasm] (R-SCE-4568758) HHF2 [nucleoplasm] (R-SCE-5423110) HHF2 [nucleoplasm] (R-SCE-3451124) HHF2 [nucleoplasm] (R-SCE-5651652) HHF2 [nucleoplasm] (R-SCE-181902)	0.744	4
UniProt:P32558	1	SPT16 [nucleoplasm] (R-SCE-112415)	0.669	8
UniProt:Q04636	1	POB3 [nucleoplasm] (R-SCE-65105)	0.669	5
UniProt:P02829	11	HSP90AB1 [secretory granule lumen] (R-SCE-6801477) HSP90AA1 [secretory granule lumen] (R-SCE-6801515) HSP90AB1 [extracellular region] (R-SCE-6806463) HSP90AA1 [ficolin-1-rich granule lumen] (R-SCE-6801470) HSP90AB1 [ficolin-1-rich granule lumen] (R-SCE-6801491) HSP90AA1 [plasma membrane] (R-SCE-534996) HSP90AA1 [extracellular region] (R-SCE-3221946) HSP90AB1 [cytosol] (R-SCE-419617) HSP90AA1 [nucleoplasm] (R-SCE-5082401) HSP90AB1 [nucleoplasm] (R-SCE-5082399) HSP90AA1 [cytosol] (R-SCE-192864)	0.547	2
UniProt:P54790 ORC3	2	yORC3 [nucleoplasm] (R-SCE-9749325) ORC3 [nucleoplasm] (R-SCE-68513)	0.527	2
UniProt:P50874 ORC5	2	yORC5 [nucleoplasm] (R-SCE-9749322) ORC5 [nucleoplasm] (R-SCE-68516)	0.527	2
UniProt:P54784 ORC1	6	ORC1 [nucleoplasm] (R-SCE-68522) yORC1 [nucleoplasm] (R-SCE-9749323) ORC1 [cytosol] (R-SCE-113840) phospho-p-S,T-ORC1 [nucleoplasm] (R-SCE-68943) phospho-PolyUb,p-S,T-ORC1 [nucleoplasm] (R-SCE-9032189) phospho-PolyUb,p-S,T-ORC1 [cytosol] (R-SCE-9032195)	0.527	2
UniProt:P32589	5	SSE1 [nucleoplasm] (R-SCE-5252053) SSE1 [nucleoplasm] (R-SCE-5251998) SSE1 [cytosol] (R-SCE-5251943) SSE1 [cytosol] (R-SCE-5251946) SSE1 [cytosol] (R-SCE-3299412)	0.527	2
UniProt:P54791 ORC4	2	yORC4 [nucleoplasm] (R-SCE-9749319) ORC4 [nucleoplasm] (R-SCE-68519)	0.527	2
UniProt:P10592	20	SSA2 [cytosol] (R-SCE-264476) SSA2 [nucleoplasm] (R-SCE-5082380) SSA2 [cytosol] (R-SCE-3371410-3) SSA2 [cytosol] (R-SCE-3371408-3) SSA2 [cytosol] (R-SCE-6792602-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801512-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801496-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801494) SSA2 [extracellular region] (R-SCE-6805872-3) SSA2 [extracellular region] (R-SCE-6806500-3) SSA2 [extracellular region] (R-SCE-6805936) SSA2 [secretory granule lumen] (R-SCE-6801530) SSA2 [secretory granule lumen] (R-SCE-6801472-3) SSA2 [nucleoplasm] (R-SCE-6792605-3) SSA2 [nucleoplasm] (R-SCE-912480-3) SSA2 [nucleoplasm] (R-SCE-5082367-3) SSA2 [nucleoplasm] (R-SCE-5252082-3) SSA2 [nucleoplasm] (R-SCE-5252088-3) SSA2 [nucleoplasm] (R-SCE-5252009-3) SSA2 [cytosol] (R-SCE-5251948-3)	0.527	2
UniProt:P27692	1	phospho-SPT5 [nucleoplasm] (R-SCE-3009372)	0.527	2
UniProt:P32833 ORC2	2	yORC2 [nucleoplasm] (R-SCE-9749316) ORC2 [nucleoplasm] (R-SCE-68405)	0.527	2

Cite Us!