Reactome | SSA1 [nucleoplasm]

SSA1 [nucleoplasm]

Stable Identifier

R-SCE-5082380-2

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

nucleoplasm

Synonyms

HSPA8, P10591

Locations in the PathwayBrowser

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Cellular responses to stimuli (Saccharomyces cerevisiae)

- Cellular responses to stress (Saccharomyces cerevisiae)
  - Cellular response to heat stress (Saccharomyces cerevisiae)
    - HSF1-dependent transactivation (Saccharomyces cerevisiae)
      - Attenuation phase (Saccharomyces cerevisiae)
        
        HSP70:DNAJB1 binds HSF1 (Saccharomyces cerevisiae)
        
        HSP70:DNAJB1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSPA (HSP70) proteins [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of HSPA8 [nucleoplasm] (Saccharomyces cerevisiae)
        
        SSA1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP70:DNAJB1:HSF1 trimer:target gene [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP70:DNAJB1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSPA (HSP70) proteins [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of HSPA8 [nucleoplasm] (Saccharomyces cerevisiae)
        
        SSA1 [nucleoplasm] (Saccharomyces cerevisiae)
      - HSF1-mediated gene expression (Saccharomyces cerevisiae)
        
        Heat shock inducible proteins [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of HSPA8 [nucleoplasm] (Saccharomyces cerevisiae)
        
        SSA1 [nucleoplasm] (Saccharomyces cerevisiae)
    - Regulation of HSF1-mediated heat shock response (Saccharomyces cerevisiae)
      - HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Saccharomyces cerevisiae)
        
        HSP70s:ADP [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSPA8:ADP [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of HSPA8 [nucleoplasm] (Saccharomyces cerevisiae)
        
        SSA1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Hikeshi:HSP70s:ATP [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP70s:ATP [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSPA8:ATP [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of HSPA8 [nucleoplasm] (Saccharomyces cerevisiae)
        
        SSA1 [nucleoplasm] (Saccharomyces cerevisiae)
      - SIRT1 binds to HSF1 (Saccharomyces cerevisiae)
        
        HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP70:DNAJB1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSPA (HSP70) proteins [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of HSPA8 [nucleoplasm] (Saccharomyces cerevisiae)
        
        SSA1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        SIRT1:HSP70:DNAJB1:Ac-K80-HSF1:target gene [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP70:DNAJB1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSPA (HSP70) proteins [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of HSPA8 [nucleoplasm] (Saccharomyces cerevisiae)
        
        SSA1 [nucleoplasm] (Saccharomyces cerevisiae)
      - SIRT1 deacetylates HSF1 (Saccharomyces cerevisiae)
        
        HSP70:DNAJB1:HSF1 trimer:target gene [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP70:DNAJB1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSPA (HSP70) proteins [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of HSPA8 [nucleoplasm] (Saccharomyces cerevisiae)
        
        SSA1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        SIRT1:HSP70:DNAJB1:Ac-K80-HSF1:target gene [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP70:DNAJB1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSPA (HSP70) proteins [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of HSPA8 [nucleoplasm] (Saccharomyces cerevisiae)
        
        SSA1 [nucleoplasm] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P10591

Gene Names

SSA1

Reference Genes

BioGPS Gene:851259 SSA1

ENSEMBL:YAL005C

KEGG:sce:YAL005C SSA1

Monarch:851259 SSA1

NCBI Gene:851259 SSA1

SGD:YAL005C

UCSC:P10591 SSA1

Reference Transcript

RefSeq:NM_001178151.1 SSA1

Other Identifiers

851259

GO:0000049

GO:0000166

GO:0000209

GO:0000329

GO:0002181

GO:0003674

GO:0003723

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005618

GO:0005634

GO:0005737

GO:0005829

GO:0005844

GO:0005886

GO:0006457

GO:0006605

GO:0006606

GO:0006616

GO:0006626

GO:0006970

GO:0006986

GO:0008150

GO:0009277

GO:0009408

GO:0015031

GO:0016192

GO:0016787

GO:0016887

GO:0017053

GO:0031072

GO:0033554

GO:0034605

GO:0034620

GO:0035617

GO:0042026

GO:0043161

GO:0043167

GO:0044183

GO:0045892

GO:0051082

GO:0051085

GO:0051169

GO:0051170

GO:0051603

GO:0051787

GO:0055085

GO:0070482

GO:0070647

GO:0071470

GO:0072318

GO:0072671

GO:0090344

GO:0140662

Participates

as a member of

Homologues of HSPA8 [nucleoplasm] (Saccharomyces cerevisiae)

Other forms of this molecule

SSA1 [cytosol]

SSA1 [secretory granule lumen]

SSA1 [extracellular region]

SSA1 [ficolin-1-rich granule lumen]

SSA1 [nucleoplasm]

SSA1 [cytosol]

SSA1 [nucleoplasm]

Inferred From

HSPA8 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_009396.2

ENSEMBL

YAL005C, YAL005C, YAL005C_mRNA

PRO

P10591

PDB

5LYN, 3LCA, 5Z8I, 5Z8Q

Interactors (41)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P32589	5	SSE1 [nucleoplasm] (R-SCE-5252053) SSE1 [nucleoplasm] (R-SCE-5251998) SSE1 [cytosol] (R-SCE-5251943) SSE1 [cytosol] (R-SCE-5251946) SSE1 [cytosol] (R-SCE-3299412)	0.892	10
UniProt:Q12118 SGT2	2	SGT2 [cytosol] (R-SCE-9629049) SGT2 [cytosol] (R-SCE-5423595)	0.744	4
UniProt:P02829	11	HSP82 [cytosol] (R-SCE-192864) HSP82 [nucleoplasm] (R-SCE-5082399) HSP82 [nucleoplasm] (R-SCE-5082401) HSP82 [cytosol] (R-SCE-419617) HSP82 [plasma membrane] (R-SCE-534996) HSP82 [extracellular region] (R-SCE-3221946) HSP82 [secretory granule lumen] (R-SCE-6801515) HSP82 [secretory granule lumen] (R-SCE-6801477) HSP82 [extracellular region] (R-SCE-6806463) HSP82 [ficolin-1-rich granule lumen] (R-SCE-6801491) HSP82 [ficolin-1-rich granule lumen] (R-SCE-6801470)	0.744	5
UniProt:Q01939	2	RPT6 [cytosol] (R-SCE-68780) RPT6 [nucleoplasm] (R-SCE-174312)	0.669	3
UniProt:Q08972	1	NEW1 [cytosol] (R-SCE-5216139)	0.643	3
UniProt:P29547	1	CAM1 [cytosol] (R-SCE-156925)	0.643	3
UniProt:P14680	3	YAK1 [nucleoplasm] (R-SCE-4090405) YAK1 [nucleoplasm] (R-SCE-3215224) YAK1 [nucleoplasm] (R-SCE-3215222)	0.643	3
UniProt:P32598	1	GLC7 [cytosol] (R-SCE-163443)	0.643	3
UniProt:P40462	5	TMA108 [plasma membrane] (R-SCE-2022340) TMA108 [secretory granule membrane] (R-SCE-6806152) TMA108 [cytosol] (R-SCE-983098) TMA108 [endoplasmic reticulum lumen] (R-SCE-947609) TMA108 [endoplasmic reticulum lumen] (R-SCE-983097)	0.527	2
UniProt:P33299	4	RPT1 [cytosol] (R-SCE-68771) RPT1 [secretory granule lumen] (R-SCE-6800994) RPT1 [extracellular region] (R-SCE-6806472) RPT1 [ficolin-1-rich granule lumen] (R-SCE-6800421)	0.527	2
UniProt:P33298	1	RPT3 [cytosol] (R-SCE-68777)	0.527	2
UniProt:P38972	1	ADE6 [cytosol] (R-SCE-62500)	0.527	2
UniProt:P29055	1	SUA7 [nucleoplasm] (R-SCE-65888)	0.527	2
UniProt:P25491	3	YDJ1 [cytosol] (R-SCE-9857072) YDJ1 [cytosol] (R-SCE-3371578) YDJ1 [cytosol] (R-SCE-3371555)	0.527	3
UniProt:P38431	1	TIF5 [cytosol] (R-SCE-72616)	0.527	2
UniProt:P38886	1	RPN10 [cytosol] (R-SCE-68800)	0.527	2
UniProt:P43558	1	OTU1 [cytosol] (R-SCE-6781909)	0.527	3
UniProt:P25037	2	UBP1 [mitochondrial outer membrane] (R-SCE-5696931) UBP1 [peroxisomal membrane] (R-SCE-9674135)	0.527	2
UniProt:P15303	4	phospho-SEC23 [cytosol] (R-SCE-5685740) SEC23 [ER to Golgi transport vesicle membrane] (R-SCE-204024) SEC23 [cytosol] (R-SCE-203972) SEC23 [endoplasmic reticulum membrane] (R-SCE-203976)	0.527	2
UniProt:Q00955	5	ACC1 [cytosol] (R-SCE-1660609) ACC1 [cytosol] (R-SCE-2976730) ACC1 [mitochondrial outer membrane] (R-SCE-4167505) ACC1 [mitochondrial outer membrane] (R-SCE-2993858) phospho-ACC1 [mitochondrial outer membrane] (R-SCE-8876892)	0.527	2
UniProt:P32471	2	EFB1 [cytosol] (R-SCE-156926) EFB1 [cytosol] (R-SCE-156914)	0.527	2
UniProt:P33309	1	DOM34 [cytosol] (R-SCE-9954712)	0.527	2
UniProt:Q08723	4	RPN8 [cytosol] (R-SCE-68806) RPN8 [secretory granule lumen] (R-SCE-6801008) RPN8 [extracellular region] (R-SCE-6806488) RPN8 [ficolin-1-rich granule lumen] (R-SCE-6800406)	0.527	2
UniProt:Q12447	1	PAA1 [cytosol] (R-SCE-209813)	0.527	2
UniProt:Q08920	2	CBC2 [cytosol] (R-SCE-162458) CBC2 [nucleoplasm] (R-SCE-51463)	0.527	2
UniProt:P02994	6	TEF1; TEF2 [cytosol] (R-SCE-156905) TEF1; TEF2 [secretory granule lumen] (R-SCE-6801479) TEF1; TEF2 [extracellular region] (R-SCE-6806456) TEF1; TEF2 [ficolin-1-rich granule lumen] (R-SCE-6801528) TEF1; TEF2 [cytosol] (R-SCE-8932419) TEF1; TEF2 [cytosol] (R-SCE-8932212)	0.527	2
UniProt:P16603	11	NCP1 [peroxisomal matrix] (R-SCE-9033124) phospho-NCP1 [plasma membrane] (R-SCE-9860783) phospho-NCP1 [plasma membrane] (R-SCE-9861341) NCP1 [cytosol] (R-SCE-419293) NCP1 [cytosol] (R-SCE-202107) phospho-NCP1 [plasma membrane] (R-SCE-202139) NCP1 [cytosol] (R-SCE-202114) NCP1 [Golgi membrane] (R-SCE-534995) NCP1 [cytosol] (R-SCE-203687) NCP1 [Golgi membrane] (R-SCE-203769) NCP1 [plasma membrane] (R-SCE-534993)	0.527	2
UniProt:P40344	8	ATG3 [cytosol] (R-SCE-5671860) ATG3 [cytosol] (R-SCE-9819371) ATG3 [cytosol] (R-SCE-9819379) ATG3 [cytosol] (R-SCE-9819376) ATG3 [cytosol] (R-SCE-9819377) ATG3 [cytosol] (R-SCE-9819381) ATG3 [cytosol] (R-SCE-9819365) ATG3 [cytosol] (R-SCE-5683569)	0.527	2
UniProt:P15705	1	STI1 [cytosol] (R-SCE-443857)	0.527	2
UniProt:P22147 XRN1	2	XRN1 [cytosol] (R-SCE-429835) XRN1_YEAST [cytosol] (R-SCE-429980)	0.527	2
UniProt:Q12532 RQC2	2	RQC2 [cytosol] (R-SCE-9950031) RQC2 [cytosol] (R-SCE-9948358)	0.527	2
UniProt:Q04958	1	NTE1 [endoplasmic reticulum membrane] (R-SCE-1498821)	0.527	2
UniProt:P34216	2	EDE1 [cytosol] (R-SCE-8862264) EDE1 [cytosol] (R-SCE-3006481)	0.527	2
UniProt:P32324 EFT1	11	EFT1; EFT2 [secretory granule lumen] (R-SCE-6801504) EFT1; EFT2 [extracellular region] (R-SCE-6806499) EFT1; EFT2 [ficolin-1-rich granule lumen] (R-SCE-6801513) EFT1; EFT2 [cytosol] (R-SCE-156901) EFT1; EFT2 [cytosol] (R-SCE-5358478) EFT1; EFT2 [cytosol] (R-SCE-5367025) EFT1; EFT2 [cytosol] (R-SCE-5358472) EFT1; EFT2 [cytosol] (R-SCE-5358501) Me-diphthine EFT1 [cytosol] (R-SCE-5367013) diphthine EFT1 [cytosol] (R-SCE-5367015) EFT1; EFT2 [cytosol] (R-SCE-8932237)	0.527	3
UniProt:P12385 SUP45	4	Erf-1 [cytosol] (R-SCE-141665) SUP45 [cytosol] (R-SCE-6800157) SUP45 [cytosol] (R-SCE-9629948) SUP45 [cytosol] (R-SCE-54433)	0.527	2
UniProt:P36070	1	RRN3 [nucleoplasm] (R-SCE-73714)	0.527	2
UniProt:Q12377	4	RPN6 [cytosol] (R-SCE-68790) RPN6 [secretory granule lumen] (R-SCE-6800943) RPN6 [extracellular region] (R-SCE-6806441) RPN6 [ficolin-1-rich granule lumen] (R-SCE-6800436)	0.527	2
UniProt:P32855	1	SEC8 [plasma membrane] (R-SCE-264989)	0.527	2
UniProt:P12695	4	LAT1 [mitochondrial matrix] (R-SCE-6792585) LAT1 [mitochondrial matrix] (R-SCE-9861664) LAT1 [mitochondrial matrix] (R-SCE-9861594) LAT1 [mitochondrial matrix] (R-SCE-69969)	0.527	2
UniProt:P06786	4	TOP2 [nucleoplasm] (R-SCE-4641297) TOP2 [nucleoplasm] (R-SCE-4641359) TOP2 [nucleoplasm] (R-SCE-4641367) TOP2 [nucleoplasm] (R-SCE-1362276)	0.527	2
UniProt:P25694 CDC48	8	CDC48 [cytosol] (R-SCE-1181251) CDC48 [azurophil granule lumen] (R-SCE-6800438) CDC48 [extracellular region] (R-SCE-6806191) CDC48 [secretory granule lumen] (R-SCE-6801039) CDC48 [ficolin-1-rich granule lumen] (R-SCE-6800425) CDC48 [nucleoplasm] (R-SCE-5643745) CDC48 [cytosol] (R-SCE-8932209) CDC48 [cytosol] (R-SCE-9950047)	0.527	2

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