Reactome | RRP46 [nucleoplasm]

RRP46 [nucleoplasm]

Stable Identifier

R-SCE-6791550

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

nucleoplasm

Synonyms

EXOSC5, P53256

Locations in the PathwayBrowser for interactor UniProt:P53859 CSL4

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External Reference Information

External Reference

UniProt:P53256 RRP46

Gene Names

RRP46, YGR095C

Chain

chain:1-223

Reference Genes

BioGPS Gene:852987 RRP46

KEGG:sce:YGR095C RRP46

Monarch:852987 RRP46

NCBI Gene:852987 RRP46

UCSC:P53256 RRP46

Reference Transcript

RefSeq:NM_001181224.1 RRP46

Other Identifiers

1775054_at

4931_at

852987

GO:0000176

GO:0000177

GO:0000178

GO:0000467

GO:0000956

GO:0003674

GO:0003723

GO:0005515

GO:0005575

GO:0005634

GO:0005730

GO:0005737

GO:0006364

GO:0006396

GO:0006401

GO:0006417

GO:0008150

GO:0016075

GO:0034427

GO:0034475

GO:0043144

GO:0043628

GO:0070478

GO:0070481

GO:0070651

GO:0071028

GO:0071035

GO:0071038

GO:0071042

GO:0071051

Participates

as a component of

Exosome core complex [nucleoplasm] (Saccharomyces cerevisiae)

This entity regulates

Positively

21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Saccharomyces cerevisiae)

Other forms of this molecule

RRP46 [cytosol]

Inferred From

EXOSC5 [nucleoplasm] (Homo sapiens)

Cross References

ENSEMBL

YGR095C, YGR095C_mRNA, YGR095C

PRO

P53256

PDB

4IFD, 5G06, 5K36, 5VZJ, 5JEA, 5OKZ, 7AJT, 7D4I, 8QCF, 5C0X, 6FSZ, 6LQS, 7AJU, 4OO1, 5C0W

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P53859 CSL4	2	CSL4 [nucleoplasm] (R-SCE-6791578) CSL4 [cytosol] (R-SCE-429841)	0.969	24
UniProt:Q08162 DIS3	2	DIS3 [nucleoplasm] (R-SCE-6791517) DIS3 [cytosol] (R-SCE-429935)	0.899	18
UniProt:P46948 SKI6	2	SKI6 [nucleoplasm] (R-SCE-6791503) SKI6 [cytosol] (R-SCE-430013)	0.899	11
UniProt:Q05636 RRP45	2	RRP45 [nucleoplasm] (R-SCE-6791577) RRP45 [cytosol] (R-SCE-429984)	0.813	15
UniProt:P48240 MTR3	2	MTR3 [nucleoplasm] (R-SCE-6791573) MTR3 [cytosol] (R-SCE-429921)	0.813	8
UniProt:P25359 RRP43	2	RRP43 [nucleoplasm] (R-SCE-6791571) RRP43 [cytosol] (R-SCE-429912)	0.813	10
UniProt:Q08285 RRP40	2	RRP40 [nucleoplasm] (R-SCE-6791572) RRP40 [cytosol] (R-SCE-430017)	0.813	11
UniProt:Q12277 RRP42	2	RRP42 [nucleoplasm] (R-SCE-6791543) RRP42 [cytosol] (R-SCE-430030)	0.813	11
UniProt:P38792 RRP4	2	RRP4 [nucleoplasm] (R-SCE-6791582) RRP4 [cytosol] (R-SCE-429999)	0.813	13
UniProt:Q12149	1	EXOSC10 [nucleoplasm] (R-SCE-6791547)	0.758	15
UniProt:P53725 MPP6			0.564	3
UniProt:Q08965 BMS1	2	BMS1 [nucleoplasm] (R-SCE-6790636) BMS1 [nucleoplasm] (R-SCE-6790720)	0.528	2
UniProt:P38801	1	LRP1 [nucleoplasm] (R-SCE-6791515)	0.527	2
UniProt:P40150	17	HSPA6 [cytosol] (R-SCE-3371521-6) HSPA13 [cytosol] (R-SCE-5251981-6) HSPA14 [cytosol] (R-SCE-5251948-6) HSPA13 [nucleoplasm] (R-SCE-5252009-6) HSPA6 [nucleoplasm] (R-SCE-5252088-6) HSPA14 [nucleoplasm] (R-SCE-5252082-6) HSPA1L [nucleoplasm] (R-SCE-5082367-6) HSPA2 [nucleoplasm] (R-SCE-912480-6) HSPA1A [nucleoplasm] (R-SCE-6792605-6) HSPA6 [secretory granule lumen] (R-SCE-6801472-6) HSPA6 [extracellular region] (R-SCE-6806500-6) HSPA1A [extracellular region] (R-SCE-6805872-6) HSPA1A [ficolin-1-rich granule lumen] (R-SCE-6801496-6) HSPA6 [ficolin-1-rich granule lumen] (R-SCE-6801512-6) HSPA1A [cytosol] (R-SCE-6792602-6) HSPA2 [cytosol] (R-SCE-3371408-6) HSPA1L [cytosol] (R-SCE-3371410-6)	0.527	2
UniProt:P53254 UTP22	2	UTP22 [nucleoplasm] (R-SCE-6790602) UTP22 [nucleoplasm] (R-SCE-6790688)	0.527	2
UniProt:P10592	20	SSA2 [cytosol] (R-SCE-264476) SSA2 [nucleoplasm] (R-SCE-5082380) SSA2 [cytosol] (R-SCE-3371410-3) SSA2 [cytosol] (R-SCE-3371408-3) SSA2 [cytosol] (R-SCE-6792602-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801512-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801496-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801494) SSA2 [extracellular region] (R-SCE-6805872-3) SSA2 [extracellular region] (R-SCE-6806500-3) SSA2 [extracellular region] (R-SCE-6805936) SSA2 [secretory granule lumen] (R-SCE-6801530) SSA2 [secretory granule lumen] (R-SCE-6801472-3) SSA2 [nucleoplasm] (R-SCE-6792605-3) SSA2 [nucleoplasm] (R-SCE-912480-3) SSA2 [nucleoplasm] (R-SCE-5082367-3) SSA2 [nucleoplasm] (R-SCE-5252082-3) SSA2 [nucleoplasm] (R-SCE-5252088-3) SSA2 [nucleoplasm] (R-SCE-5252009-3) SSA2 [cytosol] (R-SCE-5251948-3)	0.527	2

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