Reactome | BIT61 [cytosol]

BIT61 [cytosol]

Stable Identifier

R-SCE-6795323-2

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

PRR5, P47041

Locations in the PathwayBrowser

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Cellular responses to stimuli (Saccharomyces cerevisiae)

- Cellular responses to mechanical stimuli (Saccharomyces cerevisiae)
  - Response of endothelial cells to shear stress (Saccharomyces cerevisiae)
    - High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Saccharomyces cerevisiae)
      - mTORC2 phosphorylates AKT1 on serine-473 (Saccharomyces cerevisiae)
        
        TORC2 complex [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of PRR5 [cytosol] (Saccharomyces cerevisiae)
        
        BIT61 [cytosol] (Saccharomyces cerevisiae)

Gene expression (Transcription) (Saccharomyces cerevisiae)

- RNA Polymerase II Transcription (Saccharomyces cerevisiae)
  - Generic Transcription Pathway (Saccharomyces cerevisiae)
    - Transcriptional Regulation by TP53 (Saccharomyces cerevisiae)
      - Regulation of TP53 Activity (Saccharomyces cerevisiae)
        
        Regulation of TP53 Expression and Degradation (Saccharomyces cerevisiae)
        
        Regulation of TP53 Degradation (Saccharomyces cerevisiae)
        
        TORC2 complex phosphorylates SGK1 (Saccharomyces cerevisiae)
        
        TORC2 complex [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of PRR5 [cytosol] (Saccharomyces cerevisiae)
        
        BIT61 [cytosol] (Saccharomyces cerevisiae)

Immune System (Saccharomyces cerevisiae)

- Adaptive Immune System (Saccharomyces cerevisiae)
  - Regulation of T cell activation by CD28 family (Saccharomyces cerevisiae)
    - Co-stimulation by CD28 (Saccharomyces cerevisiae)
      - CD28 dependent PI3K/Akt signaling (Saccharomyces cerevisiae)
        
        TORC2 (mTOR) phosphorylates AKT at S473 (Saccharomyces cerevisiae)
        
        TORC2 complex [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of PRR5 [cytosol] (Saccharomyces cerevisiae)
        
        BIT61 [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P47041

Gene Names

BIT61

Reference Genes

BioGPS Gene:853388 BIT61

ENSEMBL:YJL058C

KEGG:sce:YJL058C BIT61

Monarch:853388 BIT61

NCBI Gene:853388 BIT61

SGD:YJL058C

UCSC:P47041 BIT61

Reference Transcript

RefSeq:NM_001181491.1 BIT61

Other Identifiers

11099_at

1779908_at

853388

GO:0001558

GO:0003674

GO:0005515

GO:0005575

GO:0005737

GO:0005773

GO:0005774

GO:0005886

GO:0007010

GO:0008150

GO:0016020

GO:0023052

GO:0030950

GO:0031505

GO:0031929

GO:0031932

GO:0038203

GO:0071554

GO:0071944

Participates

as a member of

Homologues of PRR5 [cytosol] (Saccharomyces cerevisiae)

Inferred From

PRR5 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_012477.1

ENSEMBL

YJL058C_mRNA

PRO

P47041

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3