Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PRE6 [cytosol]
Stable Identifier
R-SCE-68736
Type
Protein [EntityWithAccessionedSequence]
Species
Saccharomyces cerevisiae
Compartment
cytosol
Synonyms
PSMA7, P40303
Locations in the PathwayBrowser
Expand all
Cell Cycle (Saccharomyces cerevisiae)
Cell Cycle Checkpoints (Saccharomyces cerevisiae)
G1/S DNA Damage Checkpoints (Saccharomyces cerevisiae)
p53-Independent G1/S DNA damage checkpoint (Saccharomyces cerevisiae)
p53-Independent DNA Damage Response (Saccharomyces cerevisiae)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Saccharomyces cerevisiae)
Proteolytic degradation of ubiquitinated-Cdc25A (Saccharomyces cerevisiae)
26S proteasome [cytosol] (Saccharomyces cerevisiae)
20S core particle [cytosol] (Saccharomyces cerevisiae)
20S CP outer ring [cytosol] (Saccharomyces cerevisiae)
PRE6 [cytosol] (Saccharomyces cerevisiae)
Cell Cycle, Mitotic (Saccharomyces cerevisiae)
Mitotic G2-G2/M phases (Saccharomyces cerevisiae)
G2/M Transition (Saccharomyces cerevisiae)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Saccharomyces cerevisiae)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Saccharomyces cerevisiae)
26S proteasome [cytosol] (Saccharomyces cerevisiae)
20S core particle [cytosol] (Saccharomyces cerevisiae)
20S CP outer ring [cytosol] (Saccharomyces cerevisiae)
PRE6 [cytosol] (Saccharomyces cerevisiae)
Proteasome-mediated degradation of PolyUb-FBXL7 (Saccharomyces cerevisiae)
26S proteasome [cytosol] (Saccharomyces cerevisiae)
20S core particle [cytosol] (Saccharomyces cerevisiae)
20S CP outer ring [cytosol] (Saccharomyces cerevisiae)
PRE6 [cytosol] (Saccharomyces cerevisiae)
S Phase (Saccharomyces cerevisiae)
Synthesis of DNA (Saccharomyces cerevisiae)
Switching of origins to a post-replicative state (Saccharomyces cerevisiae)
CDK-mediated phosphorylation and removal of Cdc6 (Saccharomyces cerevisiae)
Ubiquitinated Cdc6 is degraded by the proteasome (Saccharomyces cerevisiae)
26S proteasome [cytosol] (Saccharomyces cerevisiae)
20S core particle [cytosol] (Saccharomyces cerevisiae)
20S CP outer ring [cytosol] (Saccharomyces cerevisiae)
PRE6 [cytosol] (Saccharomyces cerevisiae)
Orc1 removal from chromatin (Saccharomyces cerevisiae)
Ubiquitinated Orc1 is degraded by the proteasome (Saccharomyces cerevisiae)
26S proteasome [cytosol] (Saccharomyces cerevisiae)
20S core particle [cytosol] (Saccharomyces cerevisiae)
20S CP outer ring [cytosol] (Saccharomyces cerevisiae)
PRE6 [cytosol] (Saccharomyces cerevisiae)
Cellular responses to stimuli (Saccharomyces cerevisiae)
Cellular responses to stress (Saccharomyces cerevisiae)
Cellular response to chemical stress (Saccharomyces cerevisiae)
KEAP1-NFE2L2 pathway (Saccharomyces cerevisiae)
ub UBXN7 is degraded by the 26S proteasome (Saccharomyces cerevisiae)
26S proteasome [cytosol] (Saccharomyces cerevisiae)
20S core particle [cytosol] (Saccharomyces cerevisiae)
20S CP outer ring [cytosol] (Saccharomyces cerevisiae)
PRE6 [cytosol] (Saccharomyces cerevisiae)
DNA Replication (Saccharomyces cerevisiae)
Synthesis of DNA (Saccharomyces cerevisiae)
Switching of origins to a post-replicative state (Saccharomyces cerevisiae)
CDK-mediated phosphorylation and removal of Cdc6 (Saccharomyces cerevisiae)
Ubiquitinated Cdc6 is degraded by the proteasome (Saccharomyces cerevisiae)
26S proteasome [cytosol] (Saccharomyces cerevisiae)
20S core particle [cytosol] (Saccharomyces cerevisiae)
20S CP outer ring [cytosol] (Saccharomyces cerevisiae)
PRE6 [cytosol] (Saccharomyces cerevisiae)
Orc1 removal from chromatin (Saccharomyces cerevisiae)
Ubiquitinated Orc1 is degraded by the proteasome (Saccharomyces cerevisiae)
26S proteasome [cytosol] (Saccharomyces cerevisiae)
20S core particle [cytosol] (Saccharomyces cerevisiae)
20S CP outer ring [cytosol] (Saccharomyces cerevisiae)
PRE6 [cytosol] (Saccharomyces cerevisiae)
Immune System (Saccharomyces cerevisiae)
Adaptive Immune System (Saccharomyces cerevisiae)
Class I MHC mediated antigen processing & presentation (Saccharomyces cerevisiae)
Antigen processing-Cross presentation (Saccharomyces cerevisiae)
Cross-presentation of soluble exogenous antigens (endosomes) (Saccharomyces cerevisiae)
Proteasomal clevage of exogenous antigen (26S proteasome catalyst) (Saccharomyces cerevisiae)
26S proteasome [cytosol] (Saccharomyces cerevisiae)
20S core particle [cytosol] (Saccharomyces cerevisiae)
20S CP outer ring [cytosol] (Saccharomyces cerevisiae)
PRE6 [cytosol] (Saccharomyces cerevisiae)
Antigen processing: Ubiquitination & Proteasome degradation (Saccharomyces cerevisiae)
Proteasomal cleavage of substrate (Saccharomyces cerevisiae)
26S proteasome [cytosol] (Saccharomyces cerevisiae)
20S core particle [cytosol] (Saccharomyces cerevisiae)
20S CP outer ring [cytosol] (Saccharomyces cerevisiae)
PRE6 [cytosol] (Saccharomyces cerevisiae)
Cytokine Signaling in Immune system (Saccharomyces cerevisiae)
TNFR2 non-canonical NF-kB pathway (Saccharomyces cerevisiae)
26Sproteasome degrades K48polyUb-NIK (Saccharomyces cerevisiae)
26S proteasome [cytosol] (Saccharomyces cerevisiae)
20S core particle [cytosol] (Saccharomyces cerevisiae)
20S CP outer ring [cytosol] (Saccharomyces cerevisiae)
PRE6 [cytosol] (Saccharomyces cerevisiae)
Metabolism of proteins (Saccharomyces cerevisiae)
Post-translational protein modification (Saccharomyces cerevisiae)
Deubiquitination (Saccharomyces cerevisiae)
Ub-specific processing proteases (Saccharomyces cerevisiae)
ADRM1:26S proteaseome binds USP14 (Saccharomyces cerevisiae)
ADRM1:26S proteasome [cytosol] (Saccharomyces cerevisiae)
26S proteasome [cytosol] (Saccharomyces cerevisiae)
20S core particle [cytosol] (Saccharomyces cerevisiae)
20S CP outer ring [cytosol] (Saccharomyces cerevisiae)
PRE6 [cytosol] (Saccharomyces cerevisiae)
ADRM1:26S proteasome:USP14 [cytosol] (Saccharomyces cerevisiae)
ADRM1:26S proteasome [cytosol] (Saccharomyces cerevisiae)
26S proteasome [cytosol] (Saccharomyces cerevisiae)
20S core particle [cytosol] (Saccharomyces cerevisiae)
20S CP outer ring [cytosol] (Saccharomyces cerevisiae)
PRE6 [cytosol] (Saccharomyces cerevisiae)
Neddylation (Saccharomyces cerevisiae)
ub UBXN7 is degraded by the 26S proteasome (Saccharomyces cerevisiae)
26S proteasome [cytosol] (Saccharomyces cerevisiae)
20S core particle [cytosol] (Saccharomyces cerevisiae)
20S CP outer ring [cytosol] (Saccharomyces cerevisiae)
PRE6 [cytosol] (Saccharomyces cerevisiae)
Proteasome assembly (Saccharomyces cerevisiae)
Formation of the preholoproteasome (Saccharomyces cerevisiae)
Half-proteasome [cytosol] (Saccharomyces cerevisiae)
20S CP outer ring [cytosol] (Saccharomyces cerevisiae)
PRE6 [cytosol] (Saccharomyces cerevisiae)
Preholoproteasome [cytosol] (Saccharomyces cerevisiae)
Half-proteasome [cytosol] (Saccharomyces cerevisiae)
20S CP outer ring [cytosol] (Saccharomyces cerevisiae)
PRE6 [cytosol] (Saccharomyces cerevisiae)
Formation of the preholothymoproteasome (Saccharomyces cerevisiae)
Half-thymoproteasome [cytosol] (Saccharomyces cerevisiae)
20S CP outer ring [cytosol] (Saccharomyces cerevisiae)
PRE6 [cytosol] (Saccharomyces cerevisiae)
Preholothymoproteasome [cytosol] (Saccharomyces cerevisiae)
Half-thymoproteasome [cytosol] (Saccharomyces cerevisiae)
20S CP outer ring [cytosol] (Saccharomyces cerevisiae)
PRE6 [cytosol] (Saccharomyces cerevisiae)
Fromation of the preholoimmunoproteasome (Saccharomyces cerevisiae)
Half-immunoproteasome [cytosol] (Saccharomyces cerevisiae)
20S CP outer ring [cytosol] (Saccharomyces cerevisiae)
PRE6 [cytosol] (Saccharomyces cerevisiae)
Preholoimmunoproteasome [cytosol] (Saccharomyces cerevisiae)
Half-immunoproteasome [cytosol] (Saccharomyces cerevisiae)
20S CP outer ring [cytosol] (Saccharomyces cerevisiae)
PRE6 [cytosol] (Saccharomyces cerevisiae)
Signal Transduction (Saccharomyces cerevisiae)
Intracellular signaling by second messengers (Saccharomyces cerevisiae)
PIP3 activates AKT signaling (Saccharomyces cerevisiae)
PTEN Regulation (Saccharomyces cerevisiae)
Regulation of PTEN stability and activity (Saccharomyces cerevisiae)
Proteasome degrades polyubiquitinated PTEN (Saccharomyces cerevisiae)
26S proteasome [cytosol] (Saccharomyces cerevisiae)
20S core particle [cytosol] (Saccharomyces cerevisiae)
20S CP outer ring [cytosol] (Saccharomyces cerevisiae)
PRE6 [cytosol] (Saccharomyces cerevisiae)
MAPK family signaling cascades (Saccharomyces cerevisiae)
MAPK6/MAPK4 signaling (Saccharomyces cerevisiae)
MAPK6 is degraded by the 26S proteasome (Saccharomyces cerevisiae)
26S proteasome [cytosol] (Saccharomyces cerevisiae)
20S core particle [cytosol] (Saccharomyces cerevisiae)
20S CP outer ring [cytosol] (Saccharomyces cerevisiae)
PRE6 [cytosol] (Saccharomyces cerevisiae)
External Reference Information
External Reference
UniProt:P40303
Gene Names
PRE6
Reference Genes
BioGPS Gene:854119 PRE6
ENSEMBL:YOL038W
KEGG:sce:YOL038W PRE6
Monarch:854119 PRE6
NCBI Gene:854119 PRE6
SGD:YOL038W
UCSC:P40303 PRE6
Reference Transcript
RefSeq:NM_001183292.1 PRE6
Other Identifiers
1773650_at
854119
8614_at
GO:0000502
GO:0003674
GO:0004298
GO:0005515
GO:0005575
GO:0005634
GO:0005737
GO:0005739
GO:0005839
GO:0006511
GO:0008150
GO:0008233
GO:0010498
GO:0010499
GO:0012505
GO:0016020
GO:0016787
GO:0019773
GO:0034515
GO:0042175
GO:0043161
GO:0051603
Participates
as a component of
20S CP outer ring [cytosol] (Saccharomyces cerevisiae)
Inferred From
PSMA7 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_014604.1
ENSEMBL
YOL038W_mRNA
PRO
P40303
PDB
6HW8
,
6HV7
,
5DKI
,
4Y6V
,
3NZW
,
4G4S
,
4Y8M
,
5L68
,
4INT
,
6HUC
,
4Y84
,
6ZOU
,
4QVQ
,
5L66
,
4Z1L
,
4QWG
,
8RHL
,
5D0X
,
5L5J
,
2ZCY
,
6HVR
,
5L52
,
4EU2
,
3MG4
,
4GK7
,
6J2X
,
5L69
,
5L5P
,
4QZ3
,
4QWK
,
4Y82
,
5FGF
,
4YA0
,
5FG7
,
5CGH
,
6HUB
,
1G65
,
5MPC
,
4QV0
,
3DY4
,
4QV3
,
4X6Z
,
4QZZ
,
5L5X
,
6HVW
,
5CZ9
,
3SHJ
,
6HUQ
,
6HUV
,
5L5W
,
4HRD
,
7TEJ
,
4Y75
,
4QZ7
,
4V7O
,
3OKJ
,
5L5U
,
3OEV
,
6HW4
,
3UN8
,
6FVX
,
6HW9
,
3MG8
,
4Y81
,
4Y8H
,
4NO1
,
6HTD
,
4QWU
,
6HWD
,
5L62
,
4Y8R
,
6J30
,
7O2L
,
4QVW
,
4JSQ
,
4YA5
,
5CGF
,
5MPA
,
7LS5
,
3DY3
,
4QV1
,
5FGD
,
6HVV
,
6HWB
,
4QVY
,
4QXJ
,
5L5V
,
6HTC
,
6GOP
,
4Y7W
,
4Y78
,
4Y8O
,
6HVU
,
6ZP8
,
3D29
,
4QLS
,
5CZ5
,
4Q1S
,
7QO3
,
5L65
,
8OLR
,
4QWL
,
5L54
,
4QW3
,
5D0W
,
5L5Z
,
4QBY
,
5L5B
,
4QZ4
,
5WVI
,
6HVA
,
3SDI
,
4NO6
,
5AHJ
,
4YA7
,
4R17
,
4QVM
,
4QW4
,
4QV4
,
6HWF
,
2F16
,
5FGI
,
4Y8T
,
3NZX
,
5D0S
,
5CZA
,
4Y77
,
6HUU
,
5CZ8
,
4Y8N
,
4QZ0
,
5BXN
,
6EF0
,
4QLQ
,
4INU
,
6ZP6
,
1RYP
,
5L5T
,
5L55
,
8RHJ
,
7LSX
,
4QWI
,
5CGI
,
6HW3
,
6HTP
,
8T0M
,
6HWC
,
5L5A
,
6EF1
,
4Y8I
,
6J2N
,
5L61
,
3GPW
,
4YA1
,
5FG9
,
7LS6
,
5CGG
,
4QVL
,
5MPB
,
4J70
,
4R02
,
4Y8S
,
5BOU
,
6HTB
,
5A5B
,
5L5Y
,
1JD2
,
3NZJ
,
5L5O
,
4Y8G
,
4QLU
,
3HYE
,
4Y8K
,
5CZ4
,
3BDM
,
6HV5
,
6HVT
,
4QV6
,
5MP9
,
4Y70
,
1G0U
,
6G8N
,
6FVU
,
4LTC
,
8T08
,
5L64
,
4Y69
,
3WXR
,
4Y7X
,
6FVW
,
6HW0
,
5L5F
,
4QV9
,
5D0V
,
4NO8
,
6H39
,
5FHS
,
8BW1
,
3GPT
,
4QW0
,
4Y9Y
,
4QW6
,
5L6A
,
2GPL
,
6HWE
,
4Y8U
,
4HNP
,
5LTT
,
5M2B
,
6HW7
,
6HWA
,
4QLT
,
4Y8P
,
5DKJ
,
4QZ1
,
5L67
,
3TDD
,
4CR3
,
4QZ5
,
4Y6Z
,
6HW6
,
5NIF
,
6J2Q
,
8RHK
,
4Y8J
,
5L5E
,
4QWX
,
5L5S
,
3SDK
,
6EF3
,
4QUX
,
7TEO
,
5WVK
,
6HTR
,
3UN4
,
6J2C
,
4YA2
,
4YA9
,
4NNW
,
4R18
,
4QW5
,
4QVN
,
4QV5
,
5L6B
,
5LAJ
,
5FGH
,
5JHS
,
4NNN
,
5L5Q
,
4RUR
,
4CR2
,
5LAI
,
4QZX
,
6G7F
,
5D0T
,
5BXL
,
4QV8
,
6HV4
,
4INR
,
5L6C
,
5CZ6
,
4Y8L
,
7QO5
,
6G8M
,
5L63
,
8U7U
,
6FVY
,
5JHR
,
4Y6A
,
5L5H
,
6HVS
,
6HVX
,
4QWS
,
3MG0
,
4QZ2
,
3MG7
,
4QWF
,
4FZG
,
8OI1
,
4QW1
,
3GPJ
,
5FGG
,
4JT0
,
4QW7
,
4YA4
,
3JCP
,
1FNT
,
5FGE
,
6HV3
,
6EF2
,
4QLV
,
1Z7Q
,
4R00
,
8OHZ
,
5L60
,
8U6Y
,
4Y80
,
3MG6
,
4FZC
,
6HW5
,
4CR4
,
4QV7
,
5D0Z
,
4QZW
,
5CZ7
,
4HRC
,
4Y74
,
4QZ6
,
4QUY
,
5L5D
,
6FVT
,
5L5R
,
5L5I
,
6HVY
,
4Y7Y
,
4Y8Q
,
3E47
,
4QWJ
,
4QWR
,
6FVV
,
3OEU
,
5FGA
,
4QVP
,
4QVV
,
4LQI
,
4JSU
,
4Y9Z
,
3JCO
,
2FAK
,
4NO9
,
4YA3
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P53549
1
PSMC6 [cytosol]
(R-SCE-68783)
0.638
3
UniProt:P43588
4
PSMD14 [cytosol]
(R-SCE-68722)
PSMD14 [secretory granule lumen]
(R-SCE-6800926)
PSMD14 [extracellular region]
(R-SCE-6806511)
PSMD14 [ficolin-1-rich granule lumen]
(R-SCE-6800419)
0.564
2
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.556
3
UniProt:P32589
5
SSE1 [nucleoplasm]
(R-SCE-5252053)
SSE1 [nucleoplasm]
(R-SCE-5251998)
SSE1 [cytosol]
(R-SCE-5251943)
SSE1 [cytosol]
(R-SCE-5251946)
SSE1 [cytosol]
(R-SCE-3299412)
0.527
2
UniProt:P33299
4
PSMC2 [cytosol]
(R-SCE-68771)
PSMC2 [secretory granule lumen]
(R-SCE-6800994)
PSMC2 [extracellular region]
(R-SCE-6806472)
PSMC2 [ficolin-1-rich granule lumen]
(R-SCE-6800421)
0.527
2
UniProt:Q08723
4
RPN8 [cytosol]
(R-SCE-68806)
RPN8 [secretory granule lumen]
(R-SCE-6801008)
RPN8 [extracellular region]
(R-SCE-6806488)
RPN8 [ficolin-1-rich granule lumen]
(R-SCE-6800406)
0.527
2
UniProt:P33298
1
PSMC4 [cytosol]
(R-SCE-68777)
0.527
2
UniProt:Q04062
4
RPN9 [cytosol]
(R-SCE-68794)
RPN9 [secretory granule lumen]
(R-SCE-6800983)
RPN9 [extracellular region]
(R-SCE-6806469)
RPN9 [ficolin-1-rich granule lumen]
(R-SCE-6800413)
0.527
2
UniProt:Q12250
4
RPN5 [cytosol]
(R-SCE-68792)
RPN5 [secretory granule lumen]
(R-SCE-6800934)
RPN5 [extracellular region]
(R-SCE-6806480)
RPN5 [ficolin-1-rich granule lumen]
(R-SCE-6800416)
0.527
2
UniProt:Q12377
4
RPN6 [cytosol]
(R-SCE-68790)
RPN6 [secretory granule lumen]
(R-SCE-6800943)
RPN6 [extracellular region]
(R-SCE-6806441)
RPN6 [ficolin-1-rich granule lumen]
(R-SCE-6800436)
0.527
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text