Reactome | RPT1 [cytosol]

RPT1 [cytosol]

Stable Identifier

R-SCE-68771

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

PSMC2, P33299

Locations in the PathwayBrowser

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Immune System (Saccharomyces cerevisiae)

- Adaptive Immune System (Saccharomyces cerevisiae)
  - Class I MHC mediated antigen processing & presentation (Saccharomyces cerevisiae)
    - Antigen processing-Cross presentation (Saccharomyces cerevisiae)
      - Cross-presentation of soluble exogenous antigens (endosomes) (Saccharomyces cerevisiae)
        
        Proteasomal clevage of exogenous antigen (26S proteasome catalyst) (Saccharomyces cerevisiae)
        
        26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP base [cytosol] (Saccharomyces cerevisiae)
        
        PSMC2:PSMC1:PSMD2 [cytosol] (Saccharomyces cerevisiae)
        
        PSMC2:PSMC1 [cytosol] (Saccharomyces cerevisiae)
        
        RPT1 [cytosol] (Saccharomyces cerevisiae)
- Cytokine Signaling in Immune system (Saccharomyces cerevisiae)
  - TNFR2 non-canonical NF-kB pathway (Saccharomyces cerevisiae)
    - 26Sproteasome degrades K48polyUb-NIK (Saccharomyces cerevisiae)
      - 26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP base [cytosol] (Saccharomyces cerevisiae)
        
        PSMC2:PSMC1:PSMD2 [cytosol] (Saccharomyces cerevisiae)
        
        PSMC2:PSMC1 [cytosol] (Saccharomyces cerevisiae)
        
        RPT1 [cytosol] (Saccharomyces cerevisiae)

Metabolism of proteins (Saccharomyces cerevisiae)

- Post-translational protein modification (Saccharomyces cerevisiae)
  - Deubiquitination (Saccharomyces cerevisiae)
    - Ub-specific processing proteases (Saccharomyces cerevisiae)
      - ADRM1:26S proteaseome binds USP14 (Saccharomyces cerevisiae)
        
        ADRM1:26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP base [cytosol] (Saccharomyces cerevisiae)
        
        PSMC2:PSMC1:PSMD2 [cytosol] (Saccharomyces cerevisiae)
        
        PSMC2:PSMC1 [cytosol] (Saccharomyces cerevisiae)
        
        RPT1 [cytosol] (Saccharomyces cerevisiae)
        
        ADRM1:26S proteasome:USP14 [cytosol] (Saccharomyces cerevisiae)
        
        ADRM1:26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP base [cytosol] (Saccharomyces cerevisiae)
        
        PSMC2:PSMC1:PSMD2 [cytosol] (Saccharomyces cerevisiae)
        
        PSMC2:PSMC1 [cytosol] (Saccharomyces cerevisiae)
        
        RPT1 [cytosol] (Saccharomyces cerevisiae)
  - Proteasome assembly (Saccharomyces cerevisiae)
    - Formation of the 19S regulatory particle precursor (Saccharomyces cerevisiae)
      - 19S RP base precursor [cytosol] (Saccharomyces cerevisiae)
        
        PSMD5:PSMC2:PSMC1:PSMD2 [cytosol] (Saccharomyces cerevisiae)
        
        PSMC2:PSMC1 [cytosol] (Saccharomyces cerevisiae)
        
        RPT1 [cytosol] (Saccharomyces cerevisiae)
      - 19S RP precursor [cytosol] (Saccharomyces cerevisiae)
        
        19S RP base precursor [cytosol] (Saccharomyces cerevisiae)
        
        PSMD5:PSMC2:PSMC1:PSMD2 [cytosol] (Saccharomyces cerevisiae)
        
        PSMC2:PSMC1 [cytosol] (Saccharomyces cerevisiae)
        
        RPT1 [cytosol] (Saccharomyces cerevisiae)
    - PSMC2 binds PSMC1 (Saccharomyces cerevisiae)
      - PSMC2:PSMC1 [cytosol] (Saccharomyces cerevisiae)
        
        RPT1 [cytosol] (Saccharomyces cerevisiae)
      - RPT1 [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P33299

Gene Names

RPT1

Reference Genes

BioGPS Gene:853712 RPT1

ENSEMBL:YKL145W

KEGG:sce:YKL145W RPT1

Monarch:853712 RPT1

NCBI Gene:853712 RPT1

SGD:YKL145W

UCSC:P33299 RPT1

Reference Transcript

RefSeq:NM_001179711.1 RPT1

Other Identifiers

853712

GO:0000166

GO:0000502

GO:0003674

GO:0005515

GO:0005524

GO:0005575

GO:0005634

GO:0005737

GO:0006511

GO:0008150

GO:0008540

GO:0010498

GO:0010604

GO:0016787

GO:0016887

GO:0017025

GO:0019899

GO:0031625

GO:0036402

GO:0043161

GO:0043167

GO:0045732

GO:0045899

GO:0051603

GO:0070682

GO:0080090

GO:1901800

Participates

as an input of

PSMC2 binds PSMC1 (Saccharomyces cerevisiae)

as a component of

PSMC2:PSMC1 [cytosol] (Saccharomyces cerevisiae)

Other forms of this molecule

RPT1 [secretory granule lumen]

RPT1 [extracellular region]

RPT1 [ficolin-1-rich granule lumen]

Inferred From

PSMC2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_012777.1

ENSEMBL

YKL145W, YKL145W_mRNA, YKL145W

PRO

P33299

PDB

5MP9, 5MPA, 6J30, 6J2C, 6J2N, 5MPB, 6EF0, 5MPC, 4JPO, 4CR4, 3JCP, 4CR3, 3JCO, 6FVT, 6FVU, 6FVX, 6FVY, 4CR2, 4A3V, 6EF1, 6EF2, 6J2X, 6J2Q, 7QO5, 6EF3, 3VLF, 5WVI, 5WVK, 7QO4, 5A5B, 6FVW, 6FVV

Interactors (32)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P38764	4	RPN1 [cytosol] (R-SCE-68796) RPN1 [secretory granule lumen] (R-SCE-6800919) RPN1 [extracellular region] (R-SCE-6806479) RPN1 [ficolin-1-rich granule lumen] (R-SCE-6800435)	0.952	39
UniProt:P40327	1	RPT2 [cytosol] (R-SCE-68768)	0.932	12
UniProt:Q01939	2	RPT6 [cytosol] (R-SCE-68780) RPT6 [nucleoplasm] (R-SCE-174312)	0.921	24
UniProt:P33298	1	RPT3 [cytosol] (R-SCE-68777)	0.891	7
UniProt:P53549	1	RPT4 [cytosol] (R-SCE-68783)	0.885	7
UniProt:P53196 RPN14			0.883	9
UniProt:P32628	2	RAD23 [nucleoplasm] (R-SCE-62590) RAD23 [nucleoplasm] (R-SCE-5688076)	0.872	12
UniProt:P50086	1	NAS6 [cytosol] (R-SCE-3640824-3)	0.871	7
UniProt:P38348 HSM3			0.87	11
UniProt:P38886	1	RPN10 [cytosol] (R-SCE-68800)	0.864	11
UniProt:P43593	1	UBP6 [cytosol] (R-SCE-5689541)	0.813	24
UniProt:P32565	3	RPN2 [cytosol] (R-SCE-68786) RPN2 [azurophil granule lumen] (R-SCE-6798741) RPN2 [extracellular region] (R-SCE-6806194)	0.802	16
UniProt:P33297	4	RPT5 [cytosol] (R-SCE-68774) RPT5 [secretory granule lumen] (R-SCE-6800917) RPT5 [extracellular region] (R-SCE-6806496) RPT5 [ficolin-1-rich granule lumen] (R-SCE-6800429)	0.798	6
UniProt:Q12377	4	RPN6 [cytosol] (R-SCE-68790) RPN6 [secretory granule lumen] (R-SCE-6800943) RPN6 [extracellular region] (R-SCE-6806441) RPN6 [ficolin-1-rich granule lumen] (R-SCE-6800436)	0.758	23
UniProt:P43588	4	RPN11 [cytosol] (R-SCE-68722) RPN11 [secretory granule lumen] (R-SCE-6800926) RPN11 [extracellular region] (R-SCE-6806511) RPN11 [ficolin-1-rich granule lumen] (R-SCE-6800419)	0.758	9
UniProt:P40016	4	RPN3 [cytosol] (R-SCE-68798) RPN3 [secretory granule lumen] (R-SCE-6800873) RPN3 [extracellular region] (R-SCE-6806443) RPN3 [ficolin-1-rich granule lumen] (R-SCE-6800408)	0.758	17
UniProt:Q12250	4	RPN5 [cytosol] (R-SCE-68792) RPN5 [secretory granule lumen] (R-SCE-6800934) RPN5 [extracellular region] (R-SCE-6806480) RPN5 [ficolin-1-rich granule lumen] (R-SCE-6800416)	0.744	17
UniProt:Q06103	4	RPN7 [cytosol] (R-SCE-68804) RPN7 [secretory granule lumen] (R-SCE-6801036) RPN7 [extracellular region] (R-SCE-6806486) RPN7 [ficolin-1-rich granule lumen] (R-SCE-6800440)	0.744	5
UniProt:P48510	2	DSK2 [cytosol] (R-SCE-8866006) DSK2 [cytosol] (R-SCE-8866007)	0.743	4
UniProt:O94742 SEM1			0.688	21
UniProt:P22141	1	PRE1 [cytosol] (R-SCE-68744)	0.688	3
UniProt:Q08723	4	RPN8 [cytosol] (R-SCE-68806) RPN8 [secretory granule lumen] (R-SCE-6801008) RPN8 [extracellular region] (R-SCE-6806488) RPN8 [ficolin-1-rich granule lumen] (R-SCE-6800406)	0.669	9
UniProt:Q04062	4	RPN9 [cytosol] (R-SCE-68794) RPN9 [secretory granule lumen] (R-SCE-6800983) RPN9 [extracellular region] (R-SCE-6806469) RPN9 [ficolin-1-rich granule lumen] (R-SCE-6800413)	0.669	8
UniProt:P32496	1	RPN12 [cytosol] (R-SCE-68808)	0.669	4
UniProt:O13563 RPN13			0.643	3
UniProt:P38737 ECM29			0.643	4
UniProt:Q16401 PSMD5	1	PSMD5 [cytosol] (R-HSA-68802)	0.556	3
UniProt:P10591	20	SSA1 [cytosol] (R-SCE-264476-2) SSA1 [cytosol] (R-SCE-3371410-2) SSA1 [cytosol] (R-SCE-3371408-2) SSA1 [nucleoplasm] (R-SCE-5082380-2) SSA1 [secretory granule lumen] (R-SCE-6801472-2) SSA1 [secretory granule lumen] (R-SCE-6801530-2) SSA1 [extracellular region] (R-SCE-6805936-2) SSA1 [extracellular region] (R-SCE-6806500-2) SSA1 [ficolin-1-rich granule lumen] (R-SCE-6801512-2) SSA1 [ficolin-1-rich granule lumen] (R-SCE-6801494-2) SSA1 [nucleoplasm] (R-SCE-912480-2) SSA1 [nucleoplasm] (R-SCE-5082367-2) SSA1 [nucleoplasm] (R-SCE-5252082-2) SSA1 [nucleoplasm] (R-SCE-5252088-2) SSA1 [nucleoplasm] (R-SCE-5252009-2) SSA1 [nucleoplasm] (R-SCE-5252047-2) SSA1 [cytosol] (R-SCE-5251948-2) SSA1 [cytosol] (R-SCE-5251981-2) SSA1 [cytosol] (R-SCE-3371521-2) SSA1 [cytosol] (R-SCE-5251954-2)	0.527	2
UniProt:P40303	1	PRE6 [cytosol] (R-SCE-68736)	0.527	2
UniProt:P38624	4	PRE3 [cytosol] (R-SCE-68756) PRE3 [cytosol] (R-SCE-68765) PRE3 [cytosol] (R-SCE-9908136) PRE3 [cytosol] (R-SCE-9908130)	0.527	2
UniProt:P43583 BLM10			0.508	2
UniProt:P38779 CIC1			0.499	2

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