Reactome | PSMC3 [cytosol]

PSMC3 [cytosol]

Stable Identifier

R-SCE-68774

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

P33297

Locations in the PathwayBrowser

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Cell Cycle (Saccharomyces cerevisiae)

- Cell Cycle Checkpoints (Saccharomyces cerevisiae)
  - G1/S DNA Damage Checkpoints (Saccharomyces cerevisiae)
    - p53-Independent G1/S DNA damage checkpoint (Saccharomyces cerevisiae)
      - p53-Independent DNA Damage Response (Saccharomyces cerevisiae)
        
        Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Saccharomyces cerevisiae)
        
        Proteolytic degradation of ubiquitinated-Cdc25A (Saccharomyces cerevisiae)
        
        26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP base [cytosol] (Saccharomyces cerevisiae)
        
        PSMC3:PSMC6 [cytosol] (Saccharomyces cerevisiae)
        
        PSMC3 [cytosol] (Saccharomyces cerevisiae)
- Cell Cycle, Mitotic (Saccharomyces cerevisiae)
  - Mitotic G2-G2/M phases (Saccharomyces cerevisiae)
    - G2/M Transition (Saccharomyces cerevisiae)
      - FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Saccharomyces cerevisiae)
        
        Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Saccharomyces cerevisiae)
        
        26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP base [cytosol] (Saccharomyces cerevisiae)
        
        PSMC3:PSMC6 [cytosol] (Saccharomyces cerevisiae)
        
        PSMC3 [cytosol] (Saccharomyces cerevisiae)
        
        Proteasome-mediated degradation of PolyUb-FBXL7 (Saccharomyces cerevisiae)
        
        26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP base [cytosol] (Saccharomyces cerevisiae)
        
        PSMC3:PSMC6 [cytosol] (Saccharomyces cerevisiae)
        
        PSMC3 [cytosol] (Saccharomyces cerevisiae)
  - S Phase (Saccharomyces cerevisiae)
    - Synthesis of DNA (Saccharomyces cerevisiae)
      - Switching of origins to a post-replicative state (Saccharomyces cerevisiae)
        
        CDK-mediated phosphorylation and removal of Cdc6 (Saccharomyces cerevisiae)
        
        Ubiquitinated Cdc6 is degraded by the proteasome (Saccharomyces cerevisiae)
        
        26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP base [cytosol] (Saccharomyces cerevisiae)
        
        PSMC3:PSMC6 [cytosol] (Saccharomyces cerevisiae)
        
        PSMC3 [cytosol] (Saccharomyces cerevisiae)
        
        Orc1 removal from chromatin (Saccharomyces cerevisiae)
        
        Ubiquitinated Orc1 is degraded by the proteasome (Saccharomyces cerevisiae)
        
        26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP base [cytosol] (Saccharomyces cerevisiae)
        
        PSMC3:PSMC6 [cytosol] (Saccharomyces cerevisiae)
        
        PSMC3 [cytosol] (Saccharomyces cerevisiae)

Cellular responses to stimuli (Saccharomyces cerevisiae)

- Cellular responses to stress (Saccharomyces cerevisiae)
  - Cellular response to chemical stress (Saccharomyces cerevisiae)
    - KEAP1-NFE2L2 pathway (Saccharomyces cerevisiae)
      - ub UBXN7 is degraded by the 26S proteasome (Saccharomyces cerevisiae)
        
        26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP base [cytosol] (Saccharomyces cerevisiae)
        
        PSMC3:PSMC6 [cytosol] (Saccharomyces cerevisiae)
        
        PSMC3 [cytosol] (Saccharomyces cerevisiae)

DNA Replication (Saccharomyces cerevisiae)

- Synthesis of DNA (Saccharomyces cerevisiae)
  - Switching of origins to a post-replicative state (Saccharomyces cerevisiae)
    - CDK-mediated phosphorylation and removal of Cdc6 (Saccharomyces cerevisiae)
      - Ubiquitinated Cdc6 is degraded by the proteasome (Saccharomyces cerevisiae)
        
        26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP base [cytosol] (Saccharomyces cerevisiae)
        
        PSMC3:PSMC6 [cytosol] (Saccharomyces cerevisiae)
        
        PSMC3 [cytosol] (Saccharomyces cerevisiae)
    - Orc1 removal from chromatin (Saccharomyces cerevisiae)
      - Ubiquitinated Orc1 is degraded by the proteasome (Saccharomyces cerevisiae)
        
        26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP base [cytosol] (Saccharomyces cerevisiae)
        
        PSMC3:PSMC6 [cytosol] (Saccharomyces cerevisiae)
        
        PSMC3 [cytosol] (Saccharomyces cerevisiae)

Immune System (Saccharomyces cerevisiae)

- Adaptive Immune System (Saccharomyces cerevisiae)
  - Class I MHC mediated antigen processing & presentation (Saccharomyces cerevisiae)
    - Antigen processing-Cross presentation (Saccharomyces cerevisiae)
      - Cross-presentation of soluble exogenous antigens (endosomes) (Saccharomyces cerevisiae)
        
        Proteasomal clevage of exogenous antigen (26S proteasome catalyst) (Saccharomyces cerevisiae)
        
        26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP base [cytosol] (Saccharomyces cerevisiae)
        
        PSMC3:PSMC6 [cytosol] (Saccharomyces cerevisiae)
        
        PSMC3 [cytosol] (Saccharomyces cerevisiae)
    - Antigen processing: Ubiquitination & Proteasome degradation (Saccharomyces cerevisiae)
      - Proteasomal cleavage of substrate (Saccharomyces cerevisiae)
        
        26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP base [cytosol] (Saccharomyces cerevisiae)
        
        PSMC3:PSMC6 [cytosol] (Saccharomyces cerevisiae)
        
        PSMC3 [cytosol] (Saccharomyces cerevisiae)
- Cytokine Signaling in Immune system (Saccharomyces cerevisiae)
  - TNFR2 non-canonical NF-kB pathway (Saccharomyces cerevisiae)
    - 26Sproteasome degrades K48polyUb-NIK (Saccharomyces cerevisiae)
      - 26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP base [cytosol] (Saccharomyces cerevisiae)
        
        PSMC3:PSMC6 [cytosol] (Saccharomyces cerevisiae)
        
        PSMC3 [cytosol] (Saccharomyces cerevisiae)

Signal Transduction (Saccharomyces cerevisiae)

- Intracellular signaling by second messengers (Saccharomyces cerevisiae)
  - PIP3 activates AKT signaling (Saccharomyces cerevisiae)
    - PTEN Regulation (Saccharomyces cerevisiae)
      - Regulation of PTEN stability and activity (Saccharomyces cerevisiae)
        
        Proteasome degrades polyubiquitinated PTEN (Saccharomyces cerevisiae)
        
        26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP base [cytosol] (Saccharomyces cerevisiae)
        
        PSMC3:PSMC6 [cytosol] (Saccharomyces cerevisiae)
        
        PSMC3 [cytosol] (Saccharomyces cerevisiae)
- MAPK family signaling cascades (Saccharomyces cerevisiae)
  - MAPK6/MAPK4 signaling (Saccharomyces cerevisiae)
    - MAPK6 is degraded by the 26S proteasome (Saccharomyces cerevisiae)
      - 26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP base [cytosol] (Saccharomyces cerevisiae)
        
        PSMC3:PSMC6 [cytosol] (Saccharomyces cerevisiae)
        
        PSMC3 [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P33297

Reference Genes

BioGPS Gene:854284

ENSEMBL:YOR117W

KEGG:sce:YOR117W

Monarch:854284

NCBI Gene:854284

SGD:YOR117W

UCSC:P33297

Reference Transcript

RefSeq:NM_001183536.3

Other Identifiers

1776109_at

2637_g_at

2638_s_at

8454_at

854284

GO:0000166

GO:0000502

GO:0003674

GO:0005515

GO:0005524

GO:0005575

GO:0005634

GO:0005737

GO:0006352

GO:0006366

GO:0006511

GO:0008134

GO:0008150

GO:0008540

GO:0010604

GO:0016787

GO:0016887

GO:0017025

GO:0030433

GO:0031595

GO:0031597

GO:0036402

GO:0042221

GO:0043161

GO:0043167

GO:0045899

GO:0051173

GO:0051603

GO:0070682

GO:0140657

GO:1901800

Participates

as an input of

PSMC3 binds PSMC6 (Saccharomyces cerevisiae)

as a component of

PSMC3:PSMC6 [cytosol] (Saccharomyces cerevisiae)

Other forms of this molecule

PSMC3 [ficolin-1-rich granule lumen]

PSMC3 [extracellular region]

PSMC3 [secretory granule lumen]

Inferred From

PSMC3 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_014760.3

ENSEMBL

YOR117W, YOR117W, YOR117W_mRNA

PRO

P33297

PDB

5A5B, 6FVX, 6FVY, 6FVV, 6FVW, 6FVT, 6FVU, 5WVK, 7QO4, 3WHK, 6J2Q, 6J2X, 4CR2, 7QO5, 5WVI, 6EF3, 4CR4, 5MPC, 6EF0, 5MPB, 3JCP, 6J2N, 6J2C, 3JCO, 6EF1, 6EF2, 4CR3, 5MPA, 6J30, 5MP9, 3WHL

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P53549	1	PSMC6 [cytosol] (R-SCE-68783)	0.924	11
UniProt:P33298	1	PSMC4 [cytosol] (R-SCE-68777)	0.855	7
UniProt:P40555	1	NAS2 [cytosol] (R-SCE-68810)	0.835	8
UniProt:P38348 HSM3			0.822	7
UniProt:P38764	4	RPN1 [cytosol] (R-SCE-68796) RPN1 [ficolin-1-rich granule lumen] (R-SCE-6800435) RPN1 [extracellular region] (R-SCE-6806479) RPN1 [secretory granule lumen] (R-SCE-6800919)	0.809	17
UniProt:P53196 RPN14			0.803	6
UniProt:P33299	4	PSMC2 [cytosol] (R-SCE-68771) PSMC2 [ficolin-1-rich granule lumen] (R-SCE-6800421) PSMC2 [extracellular region] (R-SCE-6806472) PSMC2 [secretory granule lumen] (R-SCE-6800994)	0.798	6
UniProt:P50086 PSD10			0.784	5
UniProt:P38886 RPN10			0.723	8
UniProt:P32628	2	RAD23 [nucleoplasm] (R-SCE-62590) RAD23 [nucleoplasm] (R-SCE-5688076)	0.688	5
UniProt:P43588	4	PSMD14 [cytosol] (R-SCE-68722) PSMD14 [ficolin-1-rich granule lumen] (R-SCE-6800419) PSMD14 [extracellular region] (R-SCE-6806511) PSMD14 [secretory granule lumen] (R-SCE-6800926)	0.688	6
UniProt:Q01939	1	PSMC5 [cytosol] (R-SCE-68780)	0.678	15
UniProt:P40327	1	PSMC1 [cytosol] (R-SCE-68768)	0.678	6
UniProt:Q12250	4	RPN5 [cytosol] (R-SCE-68792) RPN5 [ficolin-1-rich granule lumen] (R-SCE-6800416) RPN5 [extracellular region] (R-SCE-6806480) RPN5 [secretory granule lumen] (R-SCE-6800934)	0.669	11
UniProt:Q12377	4	RPN6 [cytosol] (R-SCE-68790) RPN6 [ficolin-1-rich granule lumen] (R-SCE-6800436) RPN6 [extracellular region] (R-SCE-6806441) RPN6 [secretory granule lumen] (R-SCE-6800943)	0.669	14
UniProt:Q04062	4	RPN9 [cytosol] (R-SCE-68794) RPN9 [ficolin-1-rich granule lumen] (R-SCE-6800413) RPN9 [extracellular region] (R-SCE-6806469) RPN9 [secretory granule lumen] (R-SCE-6800983)	0.669	7
UniProt:Q06103	4	RPN7 [cytosol] (R-SCE-68804) RPN7 [ficolin-1-rich granule lumen] (R-SCE-6800440) RPN7 [extracellular region] (R-SCE-6806486) RPN7 [secretory granule lumen] (R-SCE-6801036)	0.669	4
UniProt:P38737 ECM29			0.643	3
UniProt:Q08723	4	RPN8 [cytosol] (R-SCE-68806) RPN8 [ficolin-1-rich granule lumen] (R-SCE-6800406) RPN8 [extracellular region] (R-SCE-6806488) RPN8 [secretory granule lumen] (R-SCE-6801008)	0.564	7
UniProt:P43593	1	UBP6 [cytosol] (R-SCE-5689541)	0.564	25
UniProt:O94742 SEM1			0.564	15
UniProt:P32565	3	RPN2 [cytosol] (R-SCE-68786) RPN2 [azurophil granule lumen] (R-SCE-6798741) RPN2 [extracellular region] (R-SCE-6806194)	0.564	8
UniProt:P18848 ATF4	2	ATF4 [cytosol] (R-HSA-381084) ATF4 [nucleoplasm] (R-HSA-381016)	0.556	3
UniProt:Q9Y2J4 AMOTL2	1	AMOTL2 [cytosol] (R-HSA-2028606)	0.556	3
UniProt:P62333 PSMC6	2	PSMC6 [cytosol] (R-HSA-68783) PSMC6 [nucleoplasm] (R-HSA-174319)	0.556	3
UniProt:Q9P2K3-2 RCOR3			0.556	3
UniProt:O13563 RPN13			0.527	2
UniProt:P32496	1	RPN12 [cytosol] (R-SCE-68808)	0.527	2
UniProt:P43583 BLM10			0.508	2

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