Reactome | RPN2 [cytosol]

RPN2 [cytosol]

Stable Identifier

R-SCE-68786

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

PSMD1, P32565

Locations in the PathwayBrowser

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Cellular responses to stimuli (Saccharomyces cerevisiae)

- Cellular responses to stress (Saccharomyces cerevisiae)
  - Cellular response to chemical stress (Saccharomyces cerevisiae)
    - KEAP1-NFE2L2 pathway (Saccharomyces cerevisiae)
      - ub UBXN7 is degraded by the 26S proteasome (Saccharomyces cerevisiae)
        
        26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP base [cytosol] (Saccharomyces cerevisiae)
        
        RPN2 [cytosol] (Saccharomyces cerevisiae)

Immune System (Saccharomyces cerevisiae)

- Adaptive Immune System (Saccharomyces cerevisiae)
  - Class I MHC mediated antigen processing & presentation (Saccharomyces cerevisiae)
    - Antigen processing-Cross presentation (Saccharomyces cerevisiae)
      - Cross-presentation of soluble exogenous antigens (endosomes) (Saccharomyces cerevisiae)
        
        Proteasomal clevage of exogenous antigen (26S proteasome catalyst) (Saccharomyces cerevisiae)
        
        26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP base [cytosol] (Saccharomyces cerevisiae)
        
        RPN2 [cytosol] (Saccharomyces cerevisiae)
    - Antigen processing: Ubiquitination & Proteasome degradation (Saccharomyces cerevisiae)
      - Proteasomal cleavage of substrate (Saccharomyces cerevisiae)
        
        26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP base [cytosol] (Saccharomyces cerevisiae)
        
        RPN2 [cytosol] (Saccharomyces cerevisiae)
- Cytokine Signaling in Immune system (Saccharomyces cerevisiae)
  - TNFR2 non-canonical NF-kB pathway (Saccharomyces cerevisiae)
    - 26Sproteasome degrades K48polyUb-NIK (Saccharomyces cerevisiae)
      - 26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP base [cytosol] (Saccharomyces cerevisiae)
        
        RPN2 [cytosol] (Saccharomyces cerevisiae)

Metabolism of proteins (Saccharomyces cerevisiae)

- Post-translational protein modification (Saccharomyces cerevisiae)
  - Deubiquitination (Saccharomyces cerevisiae)
    - Ub-specific processing proteases (Saccharomyces cerevisiae)
      - ADRM1:26S proteaseome binds USP14 (Saccharomyces cerevisiae)
        
        ADRM1:26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP base [cytosol] (Saccharomyces cerevisiae)
        
        RPN2 [cytosol] (Saccharomyces cerevisiae)
        
        ADRM1:26S proteasome:USP14 [cytosol] (Saccharomyces cerevisiae)
        
        ADRM1:26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP base [cytosol] (Saccharomyces cerevisiae)
        
        RPN2 [cytosol] (Saccharomyces cerevisiae)
  - Neddylation (Saccharomyces cerevisiae)
    - ub UBXN7 is degraded by the 26S proteasome (Saccharomyces cerevisiae)
      - 26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP base [cytosol] (Saccharomyces cerevisiae)
        
        RPN2 [cytosol] (Saccharomyces cerevisiae)
- Translation (Saccharomyces cerevisiae)
  - Ribosome-associated quality control (Saccharomyces cerevisiae)
    - Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide (Saccharomyces cerevisiae)
      - The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide (Saccharomyces cerevisiae)
        
        26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP base [cytosol] (Saccharomyces cerevisiae)
        
        RPN2 [cytosol] (Saccharomyces cerevisiae)

Signal Transduction (Saccharomyces cerevisiae)

- Intracellular signaling by second messengers (Saccharomyces cerevisiae)
  - PIP3 activates AKT signaling (Saccharomyces cerevisiae)
    - PTEN Regulation (Saccharomyces cerevisiae)
      - Regulation of PTEN stability and activity (Saccharomyces cerevisiae)
        
        Proteasome degrades polyubiquitinated PTEN (Saccharomyces cerevisiae)
        
        26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP base [cytosol] (Saccharomyces cerevisiae)
        
        RPN2 [cytosol] (Saccharomyces cerevisiae)
- MAPK family signaling cascades (Saccharomyces cerevisiae)
  - MAPK6/MAPK4 signaling (Saccharomyces cerevisiae)
    - MAPK6 is degraded by the 26S proteasome (Saccharomyces cerevisiae)
      - 26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP base [cytosol] (Saccharomyces cerevisiae)
        
        RPN2 [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P32565

Gene Names

RPN2

Reference Genes

BioGPS Gene:854735 RPN2

ENSEMBL:YIL075C

KEGG:sce:YIL075C RPN2

Monarch:854735 RPN2

NCBI Entrez Gene:854735 RPN2

SGD:YIL075C

UCSC:P32565 RPN2

Reference Transcript

RefSeq:NM_001179425.1 RPN2

Other Identifiers

854735

GO:0000502

GO:0004175

GO:0005515

GO:0005575

GO:0005634

GO:0006511

GO:0008150

GO:0008233

GO:0008540

GO:0019899

GO:0030234

GO:0031625

GO:0034515

GO:0042176

GO:0043161

GO:0043248

GO:0051603

Participates

as a component of

Other forms of this molecule

RPN2 [nucleoplasm]

RPN2 [azurophil granule lumen]

RPN2 [extracellular region]

Inferred From

PSMD1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_012190.1

ENSEMBL

YIL075C, YIL075C, YIL075C_mRNA

PRO

P32565

PDB

4ADY, 5MPD, 5MPE, 5A5B, 6FVX, 6FVY, 6FVU, 7QO6, 6FVT, 6FVV, 6FVW, 5WVK, 7QO3, 5WVI, 7QO5, 4CR2, 6J2X, 6J2Q, 4CR4, 6J30, 6J2C, 5MPC, 5MPB, 6J2N, 3JCO, 3JCP, 4CR3

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P33299	5	PSMC2 [cytosol] (R-SCE-68771) PSMC2 [nucleoplasm] (R-SCE-174332) PSMC2 [secretory granule lumen] (R-SCE-6800994) PSMC2 [extracellular region] (R-SCE-6806472) PSMC2 [ficolin-1-rich granule lumen] (R-SCE-6800421)	0.802	16
UniProt:P43593	1	UBP6 [cytosol] (R-SCE-5689541)	0.758	23
UniProt:Q08723	5	RPN8 [cytosol] (R-SCE-68806) RPN8 [nucleoplasm] (R-SCE-174309) RPN8 [secretory granule lumen] (R-SCE-6801008) RPN8 [extracellular region] (R-SCE-6806488) RPN8 [ficolin-1-rich granule lumen] (R-SCE-6800406)	0.758	17
UniProt:P43588	5	PSMD14 [cytosol] (R-SCE-68722) PSMD14 [nucleoplasm] (R-SCE-174329) PSMD14 [secretory granule lumen] (R-SCE-6800926) PSMD14 [extracellular region] (R-SCE-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-SCE-6800419)	0.744	16
UniProt:Q12250	5	RPN5 [cytosol] (R-SCE-68792) RPN5 [nucleoplasm] (R-SCE-174339) RPN5 [secretory granule lumen] (R-SCE-6800934) RPN5 [extracellular region] (R-SCE-6806480) RPN5 [ficolin-1-rich granule lumen] (R-SCE-6800416)	0.744	19
UniProt:Q01939	2	PSMC5 [cytosol] (R-SCE-68780) PSMC5 [nucleoplasm] (R-SCE-174312)	0.688	23
UniProt:Q12377	5	RPN6 [cytosol] (R-SCE-68790) RPN6 [nucleoplasm] (R-SCE-174327) RPN6 [secretory granule lumen] (R-SCE-6800943) RPN6 [extracellular region] (R-SCE-6806441) RPN6 [ficolin-1-rich granule lumen] (R-SCE-6800436)	0.669	17
UniProt:Q04062	5	RPN9 [cytosol] (R-SCE-68794) RPN9 [nucleoplasm] (R-SCE-174326) RPN9 [secretory granule lumen] (R-SCE-6800983) RPN9 [extracellular region] (R-SCE-6806469) RPN9 [ficolin-1-rich granule lumen] (R-SCE-6800413)	0.669	13
UniProt:P32496	2	RPN12 [cytosol] (R-SCE-68808) RPN12 [nucleoplasm] (R-SCE-174318)	0.669	11
UniProt:P33298	2	PSMC4 [cytosol] (R-SCE-68777) PSMC4 [nucleoplasm] (R-SCE-174315)	0.669	13
UniProt:P53549	2	PSMC6 [cytosol] (R-SCE-68783) PSMC6 [nucleoplasm] (R-SCE-174319)	0.667	12
UniProt:P33297	5	PSMC3 [cytosol] (R-SCE-68774) PSMC3 [nucleoplasm] (R-SCE-174313) PSMC3 [secretory granule lumen] (R-SCE-6800917) PSMC3 [extracellular region] (R-SCE-6806496) PSMC3 [ficolin-1-rich granule lumen] (R-SCE-6800429)	0.564	8
UniProt:P40327	2	PSMC1 [cytosol] (R-SCE-68768) PSMC1 [nucleoplasm] (R-SCE-174338)	0.564	17