Reactome | RPN5 [cytosol]

RPN5 [cytosol]

Stable Identifier

R-SCE-68792

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

PSMD12, Q12250

Locations in the PathwayBrowser

Expand all

Immune System (Saccharomyces cerevisiae)

- Adaptive Immune System (Saccharomyces cerevisiae)
  - Class I MHC mediated antigen processing & presentation (Saccharomyces cerevisiae)
    - Antigen processing-Cross presentation (Saccharomyces cerevisiae)
      - Cross-presentation of soluble exogenous antigens (endosomes) (Saccharomyces cerevisiae)
        
        Proteasomal clevage of exogenous antigen (26S proteasome catalyst) (Saccharomyces cerevisiae)
        
        26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP lid [cytosol] (Saccharomyces cerevisiae)
        
        19S RP lid particle 2 [cytosol] (Saccharomyces cerevisiae)
        
        19S RP Lid Module 1 [cytosol] (Saccharomyces cerevisiae)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [cytosol] (Saccharomyces cerevisiae)
        
        RPN5 [cytosol] (Saccharomyces cerevisiae)
- Cytokine Signaling in Immune system (Saccharomyces cerevisiae)
  - TNFR2 non-canonical NF-kB pathway (Saccharomyces cerevisiae)
    - 26Sproteasome degrades K48polyUb-NIK (Saccharomyces cerevisiae)
      - 26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP lid [cytosol] (Saccharomyces cerevisiae)
        
        19S RP lid particle 2 [cytosol] (Saccharomyces cerevisiae)
        
        19S RP Lid Module 1 [cytosol] (Saccharomyces cerevisiae)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [cytosol] (Saccharomyces cerevisiae)
        
        RPN5 [cytosol] (Saccharomyces cerevisiae)

Metabolism of proteins (Saccharomyces cerevisiae)

- Post-translational protein modification (Saccharomyces cerevisiae)
  - Deubiquitination (Saccharomyces cerevisiae)
    - Ub-specific processing proteases (Saccharomyces cerevisiae)
      - ADRM1:26S proteaseome binds USP14 (Saccharomyces cerevisiae)
        
        ADRM1:26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP lid [cytosol] (Saccharomyces cerevisiae)
        
        19S RP lid particle 2 [cytosol] (Saccharomyces cerevisiae)
        
        19S RP Lid Module 1 [cytosol] (Saccharomyces cerevisiae)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [cytosol] (Saccharomyces cerevisiae)
        
        RPN5 [cytosol] (Saccharomyces cerevisiae)
        
        ADRM1:26S proteasome:USP14 [cytosol] (Saccharomyces cerevisiae)
        
        ADRM1:26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP lid [cytosol] (Saccharomyces cerevisiae)
        
        19S RP lid particle 2 [cytosol] (Saccharomyces cerevisiae)
        
        19S RP Lid Module 1 [cytosol] (Saccharomyces cerevisiae)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [cytosol] (Saccharomyces cerevisiae)
        
        RPN5 [cytosol] (Saccharomyces cerevisiae)
  - Proteasome assembly (Saccharomyces cerevisiae)
    - Formation of the 19S regulatory particle lid (Saccharomyces cerevisiae)
      - 19S RP lid [cytosol] (Saccharomyces cerevisiae)
        
        19S RP lid particle 2 [cytosol] (Saccharomyces cerevisiae)
        
        19S RP Lid Module 1 [cytosol] (Saccharomyces cerevisiae)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [cytosol] (Saccharomyces cerevisiae)
        
        RPN5 [cytosol] (Saccharomyces cerevisiae)
      - 19S RP lid particle 2 [cytosol] (Saccharomyces cerevisiae)
        
        19S RP Lid Module 1 [cytosol] (Saccharomyces cerevisiae)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [cytosol] (Saccharomyces cerevisiae)
        
        RPN5 [cytosol] (Saccharomyces cerevisiae)
    - Formation of the 19S regulatory particle precursor (Saccharomyces cerevisiae)
      - 19S RP lid [cytosol] (Saccharomyces cerevisiae)
        
        19S RP lid particle 2 [cytosol] (Saccharomyces cerevisiae)
        
        19S RP Lid Module 1 [cytosol] (Saccharomyces cerevisiae)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [cytosol] (Saccharomyces cerevisiae)
        
        RPN5 [cytosol] (Saccharomyces cerevisiae)
      - 19S RP precursor [cytosol] (Saccharomyces cerevisiae)
        
        19S RP lid [cytosol] (Saccharomyces cerevisiae)
        
        19S RP lid particle 2 [cytosol] (Saccharomyces cerevisiae)
        
        19S RP Lid Module 1 [cytosol] (Saccharomyces cerevisiae)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [cytosol] (Saccharomyces cerevisiae)
        
        RPN5 [cytosol] (Saccharomyces cerevisiae)
    - Formation of the complex of PSMD7, PSMD12, PSMD13, and PSMD14 (Saccharomyces cerevisiae)
      - PSMD7:PSMD12:PSMD13:PSMD14 [cytosol] (Saccharomyces cerevisiae)
        
        RPN5 [cytosol] (Saccharomyces cerevisiae)
      - RPN5 [cytosol] (Saccharomyces cerevisiae)
    - PSMD11 binds PSMD7:PSMD12:PSMD13:PSMD14 (Saccharomyces cerevisiae)
      - 19S RP Lid Module 1 [cytosol] (Saccharomyces cerevisiae)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [cytosol] (Saccharomyces cerevisiae)
        
        RPN5 [cytosol] (Saccharomyces cerevisiae)
      - PSMD7:PSMD12:PSMD13:PSMD14 [cytosol] (Saccharomyces cerevisiae)
        
        RPN5 [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:Q12250

Gene Names

RPN5

Reference Genes

BioGPS Gene:851408 RPN5

ENSEMBL:YDL147W

KEGG:sce:YDL147W RPN5

Monarch:851408 RPN5

NCBI Gene:851408 RPN5

SGD:YDL147W

UCSC:Q12250 RPN5

Reference Transcript

RefSeq:NM_001180207.1 RPN5

Other Identifiers

851408

GO:0000338

GO:0000502

GO:0005515

GO:0005575

GO:0005634

GO:0005737

GO:0008180

GO:0008541

GO:0031595

GO:0034515

GO:0043161

GO:0051603

Participates

as an input of

Formation of the complex of PSMD7, PSMD12, PSMD13, and PSMD14 (Saccharomyces cerevisiae)

as a component of

PSMD7:PSMD12:PSMD13:PSMD14 [cytosol] (Saccharomyces cerevisiae)

Other forms of this molecule

RPN5 [secretory granule lumen]

RPN5 [extracellular region]

RPN5 [ficolin-1-rich granule lumen]

Inferred From

PSMD12 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_010134.1

ENSEMBL

YDL147W, YDL147W_mRNA, YDL147W

PRO

Q12250

PDB

3JCK, 6J30, 5MPB, 5MPC, 6J2N, 6J2C, 4CR4, 3JCP, 4CR3, 3JCO, 6FVU, 6FVT, 7QO3, 5MPD, 6FVY, 6FVX, 5MPE, 4CR2, 5ZMR, 3J47, 6J2X, 6J2Q, 7QO5, 5WVI, 5WVK, 5A5B, 6FVW, 6FVV

Interactors (36)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12377	4	RPN6 [cytosol] (R-SCE-68790) RPN6 [secretory granule lumen] (R-SCE-6800943) RPN6 [extracellular region] (R-SCE-6806441) RPN6 [ficolin-1-rich granule lumen] (R-SCE-6800436)	0.922	35
UniProt:Q08723	4	RPN8 [cytosol] (R-SCE-68806) RPN8 [secretory granule lumen] (R-SCE-6801008) RPN8 [extracellular region] (R-SCE-6806488) RPN8 [ficolin-1-rich granule lumen] (R-SCE-6800406)	0.91	27
UniProt:Q04062	4	RPN9 [cytosol] (R-SCE-68794) RPN9 [secretory granule lumen] (R-SCE-6800983) RPN9 [extracellular region] (R-SCE-6806469) RPN9 [ficolin-1-rich granule lumen] (R-SCE-6800413)	0.91	23
UniProt:P43588	4	RPN11 [cytosol] (R-SCE-68722) RPN11 [secretory granule lumen] (R-SCE-6800926) RPN11 [extracellular region] (R-SCE-6806511) RPN11 [ficolin-1-rich granule lumen] (R-SCE-6800419)	0.91	22
UniProt:Q03981	1	CSN9 [cytosol] (R-SCE-377448)	0.859	11
UniProt:P38764	4	RPN1 [cytosol] (R-SCE-68796) RPN1 [secretory granule lumen] (R-SCE-6800919) RPN1 [extracellular region] (R-SCE-6806479) RPN1 [ficolin-1-rich granule lumen] (R-SCE-6800435)	0.857	29
UniProt:Q01939	2	RPT6 [cytosol] (R-SCE-68780) RPT6 [nucleoplasm] (R-SCE-174312)	0.822	21
UniProt:P53549	1	RPT4 [cytosol] (R-SCE-68783)	0.813	14
UniProt:P38886	1	RPN10 [cytosol] (R-SCE-68800)	0.813	16
UniProt:Q06103	4	RPN7 [cytosol] (R-SCE-68804) RPN7 [secretory granule lumen] (R-SCE-6801036) RPN7 [extracellular region] (R-SCE-6806486) RPN7 [ficolin-1-rich granule lumen] (R-SCE-6800440)	0.802	17
UniProt:P32496	1	RPN12 [cytosol] (R-SCE-68808)	0.802	16
UniProt:P40016	4	RPN3 [cytosol] (R-SCE-68798) RPN3 [secretory granule lumen] (R-SCE-6800873) RPN3 [extracellular region] (R-SCE-6806443) RPN3 [ficolin-1-rich granule lumen] (R-SCE-6800408)	0.8	19
UniProt:P32565	3	RPN2 [cytosol] (R-SCE-68786) RPN2 [azurophil granule lumen] (R-SCE-6798741) RPN2 [extracellular region] (R-SCE-6806194)	0.744	19
UniProt:P33299	4	RPT1 [cytosol] (R-SCE-68771) RPT1 [secretory granule lumen] (R-SCE-6800994) RPT1 [extracellular region] (R-SCE-6806472) RPT1 [ficolin-1-rich granule lumen] (R-SCE-6800421)	0.744	17
UniProt:P33298	1	RPT3 [cytosol] (R-SCE-68777)	0.744	14
UniProt:P40327	1	RPT2 [cytosol] (R-SCE-68768)	0.744	13
UniProt:P50086	1	NAS6 [cytosol] (R-SCE-3640824-3)	0.723	5
UniProt:P53196 RPN14			0.708	4
UniProt:P38348 HSM3			0.688	3
UniProt:P33297	4	RPT5 [cytosol] (R-SCE-68774) RPT5 [secretory granule lumen] (R-SCE-6800917) RPT5 [extracellular region] (R-SCE-6806496) RPT5 [ficolin-1-rich granule lumen] (R-SCE-6800429)	0.669	11
UniProt:P43593	1	UBP6 [cytosol] (R-SCE-5689541)	0.669	18
UniProt:O94742 SEM1			0.669	23
UniProt:Q12468 CSN5			0.669	5
UniProt:O13563 RPN13			0.669	6
UniProt:P38737 ECM29			0.643	3
UniProt:Q04368 CSI1			0.641	3
UniProt:Q06677	3	SWA2 [Golgi membrane] (R-SCE-434340) SWA2 [cytoplasmic vesicle membrane] (R-SCE-434203) SWA2 [cytosol] (R-SCE-264472)	0.564	4
UniProt:Q12348 CSN10			0.564	4
UniProt:P40512 CSN11			0.564	5
UniProt:P23724 PSB6			0.527	2
UniProt:P21243	1	SCL1 [cytosol] (R-SCE-68734)	0.527	2
UniProt:P10592	20	SSA2 [cytosol] (R-SCE-264476-3) SSA2 [nucleoplasm] (R-SCE-6792605) SSA2 [cytosol] (R-SCE-3371410-3) SSA2 [cytosol] (R-SCE-3371408-3) SSA2 [cytosol] (R-SCE-6792602) SSA2 [nucleoplasm] (R-SCE-5082380-3) SSA2 [secretory granule lumen] (R-SCE-6801472-3) SSA2 [secretory granule lumen] (R-SCE-6801530-3) SSA2 [extracellular region] (R-SCE-6805936-3) SSA2 [extracellular region] (R-SCE-6806500-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801496) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801512-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801494-3) SSA2 [extracellular region] (R-SCE-6805872) SSA2 [nucleoplasm] (R-SCE-912480-3) SSA2 [nucleoplasm] (R-SCE-5082367-3) SSA2 [nucleoplasm] (R-SCE-5252082-3) SSA2 [nucleoplasm] (R-SCE-5252088-3) SSA2 [nucleoplasm] (R-SCE-5252009-3) SSA2 [nucleoplasm] (R-SCE-5252047-3)	0.527	2
UniProt:P40303	1	PRE6 [cytosol] (R-SCE-68736)	0.527	2
UniProt:P40302	1	PRE5 [cytosol] (R-SCE-68724)	0.527	2
UniProt:P38624	4	PRE3 [cytosol] (R-SCE-68756) PRE3 [cytosol] (R-SCE-68765) PRE3 [cytosol] (R-SCE-9908136) PRE3 [cytosol] (R-SCE-9908130)	0.527	2
UniProt:P22141	1	PRE1 [cytosol] (R-SCE-68744)	0.527	2

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