Reactome | RPN1 [cytosol]

RPN1 [cytosol]

Stable Identifier

R-SCE-68796

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

PSMD2, P38764

Locations in the PathwayBrowser

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Immune System (Saccharomyces cerevisiae)

- Adaptive Immune System (Saccharomyces cerevisiae)
  - Class I MHC mediated antigen processing & presentation (Saccharomyces cerevisiae)
    - Antigen processing-Cross presentation (Saccharomyces cerevisiae)
      - Cross-presentation of soluble exogenous antigens (endosomes) (Saccharomyces cerevisiae)
        
        Proteasomal clevage of exogenous antigen (26S proteasome catalyst) (Saccharomyces cerevisiae)
        
        26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP base [cytosol] (Saccharomyces cerevisiae)
        
        PSMC2:PSMC1:PSMD2 [cytosol] (Saccharomyces cerevisiae)
        
        RPN1 [cytosol] (Saccharomyces cerevisiae)
- Cytokine Signaling in Immune system (Saccharomyces cerevisiae)
  - TNFR2 non-canonical NF-kB pathway (Saccharomyces cerevisiae)
    - 26Sproteasome degrades K48polyUb-NIK (Saccharomyces cerevisiae)
      - 26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP base [cytosol] (Saccharomyces cerevisiae)
        
        PSMC2:PSMC1:PSMD2 [cytosol] (Saccharomyces cerevisiae)
        
        RPN1 [cytosol] (Saccharomyces cerevisiae)

Metabolism of proteins (Saccharomyces cerevisiae)

- Post-translational protein modification (Saccharomyces cerevisiae)
  - Deubiquitination (Saccharomyces cerevisiae)
    - Ub-specific processing proteases (Saccharomyces cerevisiae)
      - ADRM1:26S proteaseome binds USP14 (Saccharomyces cerevisiae)
        
        ADRM1:26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP base [cytosol] (Saccharomyces cerevisiae)
        
        PSMC2:PSMC1:PSMD2 [cytosol] (Saccharomyces cerevisiae)
        
        RPN1 [cytosol] (Saccharomyces cerevisiae)
        
        ADRM1:26S proteasome:USP14 [cytosol] (Saccharomyces cerevisiae)
        
        ADRM1:26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP base [cytosol] (Saccharomyces cerevisiae)
        
        PSMC2:PSMC1:PSMD2 [cytosol] (Saccharomyces cerevisiae)
        
        RPN1 [cytosol] (Saccharomyces cerevisiae)
  - Proteasome assembly (Saccharomyces cerevisiae)
    - Formation of the 19S regulatory particle precursor (Saccharomyces cerevisiae)
      - 19S RP base precursor [cytosol] (Saccharomyces cerevisiae)
        
        PSMD5:PSMC2:PSMC1:PSMD2 [cytosol] (Saccharomyces cerevisiae)
        
        RPN1 [cytosol] (Saccharomyces cerevisiae)
      - 19S RP precursor [cytosol] (Saccharomyces cerevisiae)
        
        19S RP base precursor [cytosol] (Saccharomyces cerevisiae)
        
        PSMD5:PSMC2:PSMC1:PSMD2 [cytosol] (Saccharomyces cerevisiae)
        
        RPN1 [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P38764

Gene Names

RPN1

Reference Genes

BioGPS Gene:856422 RPN1

ENSEMBL:YHR027C

KEGG:sce:YHR027C RPN1

Monarch:856422 RPN1

NCBI Gene:856422 RPN1

SGD:YHR027C

UCSC:P38764 RPN1

Reference Transcript

RefSeq:NM_001179157.1 RPN1

Other Identifiers

856422

GO:0000502

GO:0003674

GO:0004175

GO:0005515

GO:0005575

GO:0005634

GO:0005737

GO:0005783

GO:0006511

GO:0008150

GO:0008233

GO:0008540

GO:0030234

GO:0030674

GO:0034515

GO:0042176

GO:0043161

GO:0051603

Participates

as a component of

Other forms of this molecule

RPN1 [secretory granule lumen]

RPN1 [extracellular region]

RPN1 [ficolin-1-rich granule lumen]

Inferred From

PSMD2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_011892.1

ENSEMBL

YHR027C, YHR027C_mRNA, YHR027C

PRO

P38764

PDB

6J30, 6J2C, 6J2N, 5MPC, 5MPB, 4CR4, 3JCP, 2N3W, 4CR3, 3JCO, 2N3T, 2N3V, 2N3U, 6FVU, 6FVT, 7QO3, 5MPE, 5MPD, 6FVX, 6FVY, 2NBW, 4CR2, 6J2X, 6J2Q, 7QO6, 7QO5, 5WVI, 5WVK, 7QO4, 5A5B, 6FVV, 6FVW

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P33299	4	RPT1 [cytosol] (R-SCE-68771) RPT1 [secretory granule lumen] (R-SCE-6800994) RPT1 [extracellular region] (R-SCE-6806472) RPT1 [ficolin-1-rich granule lumen] (R-SCE-6800421)	0.952	39
UniProt:P40327	1	RPT2 [cytosol] (R-SCE-68768)	0.88	33
UniProt:P38886	1	RPN10 [cytosol] (R-SCE-68800)	0.864	21
UniProt:Q12250	4	RPN5 [cytosol] (R-SCE-68792) RPN5 [secretory granule lumen] (R-SCE-6800934) RPN5 [extracellular region] (R-SCE-6806480) RPN5 [ficolin-1-rich granule lumen] (R-SCE-6800416)	0.857	29
UniProt:P33298	1	RPT3 [cytosol] (R-SCE-68777)	0.857	24
UniProt:Q01939	2	RPT6 [cytosol] (R-SCE-68780) RPT6 [nucleoplasm] (R-SCE-174312)	0.822	34
UniProt:Q08723	4	RPN8 [cytosol] (R-SCE-68806) RPN8 [secretory granule lumen] (R-SCE-6801008) RPN8 [extracellular region] (R-SCE-6806488) RPN8 [ficolin-1-rich granule lumen] (R-SCE-6800406)	0.813	25
UniProt:Q12377	4	RPN6 [cytosol] (R-SCE-68790) RPN6 [secretory granule lumen] (R-SCE-6800943) RPN6 [extracellular region] (R-SCE-6806441) RPN6 [ficolin-1-rich granule lumen] (R-SCE-6800436)	0.813	29
UniProt:P53549	1	RPT4 [cytosol] (R-SCE-68783)	0.813	21
UniProt:Q04062	4	RPN9 [cytosol] (R-SCE-68794) RPN9 [secretory granule lumen] (R-SCE-6800983) RPN9 [extracellular region] (R-SCE-6806469) RPN9 [ficolin-1-rich granule lumen] (R-SCE-6800413)	0.813	20
UniProt:P43588	4	RPN11 [cytosol] (R-SCE-68722) RPN11 [secretory granule lumen] (R-SCE-6800926) RPN11 [extracellular region] (R-SCE-6806511) RPN11 [ficolin-1-rich granule lumen] (R-SCE-6800419)	0.813	23
UniProt:P32496	1	RPN12 [cytosol] (R-SCE-68808)	0.813	18
UniProt:P33297	4	RPT5 [cytosol] (R-SCE-68774) RPT5 [secretory granule lumen] (R-SCE-6800917) RPT5 [extracellular region] (R-SCE-6806496) RPT5 [ficolin-1-rich granule lumen] (R-SCE-6800429)	0.809	17
UniProt:P43593	1	UBP6 [cytosol] (R-SCE-5689541)	0.758	30
UniProt:P02829	11	HSP82 [cytosol] (R-SCE-192864) HSP82 [nucleoplasm] (R-SCE-5082399) HSP82 [nucleoplasm] (R-SCE-5082401) HSP82 [cytosol] (R-SCE-419617) HSP82 [plasma membrane] (R-SCE-534996) HSP82 [extracellular region] (R-SCE-3221946) HSP82 [secretory granule lumen] (R-SCE-6801515) HSP82 [secretory granule lumen] (R-SCE-6801477) HSP82 [extracellular region] (R-SCE-6806463) HSP82 [ficolin-1-rich granule lumen] (R-SCE-6801491) HSP82 [ficolin-1-rich granule lumen] (R-SCE-6801470)	0.564	2