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RPN1 [cytosol]
Stable Identifier
R-SCE-68796
Type
Protein [EntityWithAccessionedSequence]
Species
Saccharomyces cerevisiae
Compartment
cytosol
Synonyms
PSMD2, P38764
Locations in the PathwayBrowser
Expand all
Cell Cycle (Saccharomyces cerevisiae)
Cell Cycle Checkpoints (Saccharomyces cerevisiae)
G1/S DNA Damage Checkpoints (Saccharomyces cerevisiae)
p53-Independent G1/S DNA damage checkpoint (Saccharomyces cerevisiae)
p53-Independent DNA Damage Response (Saccharomyces cerevisiae)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Saccharomyces cerevisiae)
Proteolytic degradation of ubiquitinated-Cdc25A (Saccharomyces cerevisiae)
26S proteasome [cytosol] (Saccharomyces cerevisiae)
19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
19S RP base [cytosol] (Saccharomyces cerevisiae)
PSMC2:PSMC1:PSMD2 [cytosol] (Saccharomyces cerevisiae)
RPN1 [cytosol] (Saccharomyces cerevisiae)
Cell Cycle, Mitotic (Saccharomyces cerevisiae)
Mitotic G2-G2/M phases (Saccharomyces cerevisiae)
G2/M Transition (Saccharomyces cerevisiae)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Saccharomyces cerevisiae)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Saccharomyces cerevisiae)
26S proteasome [cytosol] (Saccharomyces cerevisiae)
19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
19S RP base [cytosol] (Saccharomyces cerevisiae)
PSMC2:PSMC1:PSMD2 [cytosol] (Saccharomyces cerevisiae)
RPN1 [cytosol] (Saccharomyces cerevisiae)
Proteasome-mediated degradation of PolyUb-FBXL7 (Saccharomyces cerevisiae)
26S proteasome [cytosol] (Saccharomyces cerevisiae)
19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
19S RP base [cytosol] (Saccharomyces cerevisiae)
PSMC2:PSMC1:PSMD2 [cytosol] (Saccharomyces cerevisiae)
RPN1 [cytosol] (Saccharomyces cerevisiae)
S Phase (Saccharomyces cerevisiae)
Synthesis of DNA (Saccharomyces cerevisiae)
Switching of origins to a post-replicative state (Saccharomyces cerevisiae)
CDK-mediated phosphorylation and removal of Cdc6 (Saccharomyces cerevisiae)
Ubiquitinated Cdc6 is degraded by the proteasome (Saccharomyces cerevisiae)
26S proteasome [cytosol] (Saccharomyces cerevisiae)
19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
19S RP base [cytosol] (Saccharomyces cerevisiae)
PSMC2:PSMC1:PSMD2 [cytosol] (Saccharomyces cerevisiae)
RPN1 [cytosol] (Saccharomyces cerevisiae)
Orc1 removal from chromatin (Saccharomyces cerevisiae)
Ubiquitinated Orc1 is degraded by the proteasome (Saccharomyces cerevisiae)
26S proteasome [cytosol] (Saccharomyces cerevisiae)
19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
19S RP base [cytosol] (Saccharomyces cerevisiae)
PSMC2:PSMC1:PSMD2 [cytosol] (Saccharomyces cerevisiae)
RPN1 [cytosol] (Saccharomyces cerevisiae)
Cellular responses to stimuli (Saccharomyces cerevisiae)
Cellular responses to stress (Saccharomyces cerevisiae)
Cellular response to chemical stress (Saccharomyces cerevisiae)
KEAP1-NFE2L2 pathway (Saccharomyces cerevisiae)
ub UBXN7 is degraded by the 26S proteasome (Saccharomyces cerevisiae)
26S proteasome [cytosol] (Saccharomyces cerevisiae)
19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
19S RP base [cytosol] (Saccharomyces cerevisiae)
PSMC2:PSMC1:PSMD2 [cytosol] (Saccharomyces cerevisiae)
RPN1 [cytosol] (Saccharomyces cerevisiae)
DNA Replication (Saccharomyces cerevisiae)
Synthesis of DNA (Saccharomyces cerevisiae)
Switching of origins to a post-replicative state (Saccharomyces cerevisiae)
CDK-mediated phosphorylation and removal of Cdc6 (Saccharomyces cerevisiae)
Ubiquitinated Cdc6 is degraded by the proteasome (Saccharomyces cerevisiae)
26S proteasome [cytosol] (Saccharomyces cerevisiae)
19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
19S RP base [cytosol] (Saccharomyces cerevisiae)
PSMC2:PSMC1:PSMD2 [cytosol] (Saccharomyces cerevisiae)
RPN1 [cytosol] (Saccharomyces cerevisiae)
Orc1 removal from chromatin (Saccharomyces cerevisiae)
Ubiquitinated Orc1 is degraded by the proteasome (Saccharomyces cerevisiae)
26S proteasome [cytosol] (Saccharomyces cerevisiae)
19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
19S RP base [cytosol] (Saccharomyces cerevisiae)
PSMC2:PSMC1:PSMD2 [cytosol] (Saccharomyces cerevisiae)
RPN1 [cytosol] (Saccharomyces cerevisiae)
Immune System (Saccharomyces cerevisiae)
Adaptive Immune System (Saccharomyces cerevisiae)
Class I MHC mediated antigen processing & presentation (Saccharomyces cerevisiae)
Antigen processing-Cross presentation (Saccharomyces cerevisiae)
Cross-presentation of soluble exogenous antigens (endosomes) (Saccharomyces cerevisiae)
Proteasomal clevage of exogenous antigen (26S proteasome catalyst) (Saccharomyces cerevisiae)
26S proteasome [cytosol] (Saccharomyces cerevisiae)
19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
19S RP base [cytosol] (Saccharomyces cerevisiae)
PSMC2:PSMC1:PSMD2 [cytosol] (Saccharomyces cerevisiae)
RPN1 [cytosol] (Saccharomyces cerevisiae)
Antigen processing: Ubiquitination & Proteasome degradation (Saccharomyces cerevisiae)
Proteasomal cleavage of substrate (Saccharomyces cerevisiae)
26S proteasome [cytosol] (Saccharomyces cerevisiae)
19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
19S RP base [cytosol] (Saccharomyces cerevisiae)
PSMC2:PSMC1:PSMD2 [cytosol] (Saccharomyces cerevisiae)
RPN1 [cytosol] (Saccharomyces cerevisiae)
Cytokine Signaling in Immune system (Saccharomyces cerevisiae)
TNFR2 non-canonical NF-kB pathway (Saccharomyces cerevisiae)
26Sproteasome degrades K48polyUb-NIK (Saccharomyces cerevisiae)
26S proteasome [cytosol] (Saccharomyces cerevisiae)
19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
19S RP base [cytosol] (Saccharomyces cerevisiae)
PSMC2:PSMC1:PSMD2 [cytosol] (Saccharomyces cerevisiae)
RPN1 [cytosol] (Saccharomyces cerevisiae)
Metabolism of proteins (Saccharomyces cerevisiae)
Post-translational protein modification (Saccharomyces cerevisiae)
Deubiquitination (Saccharomyces cerevisiae)
Ub-specific processing proteases (Saccharomyces cerevisiae)
ADRM1:26S proteaseome binds USP14 (Saccharomyces cerevisiae)
ADRM1:26S proteasome [cytosol] (Saccharomyces cerevisiae)
26S proteasome [cytosol] (Saccharomyces cerevisiae)
19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
19S RP base [cytosol] (Saccharomyces cerevisiae)
PSMC2:PSMC1:PSMD2 [cytosol] (Saccharomyces cerevisiae)
RPN1 [cytosol] (Saccharomyces cerevisiae)
ADRM1:26S proteasome:USP14 [cytosol] (Saccharomyces cerevisiae)
ADRM1:26S proteasome [cytosol] (Saccharomyces cerevisiae)
26S proteasome [cytosol] (Saccharomyces cerevisiae)
19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
19S RP base [cytosol] (Saccharomyces cerevisiae)
PSMC2:PSMC1:PSMD2 [cytosol] (Saccharomyces cerevisiae)
RPN1 [cytosol] (Saccharomyces cerevisiae)
Neddylation (Saccharomyces cerevisiae)
ub UBXN7 is degraded by the 26S proteasome (Saccharomyces cerevisiae)
26S proteasome [cytosol] (Saccharomyces cerevisiae)
19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
19S RP base [cytosol] (Saccharomyces cerevisiae)
PSMC2:PSMC1:PSMD2 [cytosol] (Saccharomyces cerevisiae)
RPN1 [cytosol] (Saccharomyces cerevisiae)
Signal Transduction (Saccharomyces cerevisiae)
Intracellular signaling by second messengers (Saccharomyces cerevisiae)
PIP3 activates AKT signaling (Saccharomyces cerevisiae)
PTEN Regulation (Saccharomyces cerevisiae)
Regulation of PTEN stability and activity (Saccharomyces cerevisiae)
Proteasome degrades polyubiquitinated PTEN (Saccharomyces cerevisiae)
26S proteasome [cytosol] (Saccharomyces cerevisiae)
19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
19S RP base [cytosol] (Saccharomyces cerevisiae)
PSMC2:PSMC1:PSMD2 [cytosol] (Saccharomyces cerevisiae)
RPN1 [cytosol] (Saccharomyces cerevisiae)
MAPK family signaling cascades (Saccharomyces cerevisiae)
MAPK6/MAPK4 signaling (Saccharomyces cerevisiae)
MAPK6 is degraded by the 26S proteasome (Saccharomyces cerevisiae)
26S proteasome [cytosol] (Saccharomyces cerevisiae)
19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
19S RP base [cytosol] (Saccharomyces cerevisiae)
PSMC2:PSMC1:PSMD2 [cytosol] (Saccharomyces cerevisiae)
RPN1 [cytosol] (Saccharomyces cerevisiae)
External Reference Information
External Reference
UniProt:P38764
Gene Names
RPN1
Reference Genes
BioGPS Gene:856422 RPN1
ENSEMBL:YHR027C
KEGG:sce:YHR027C RPN1
Monarch:856422 RPN1
NCBI Gene:856422 RPN1
SGD:YHR027C
UCSC:P38764 RPN1
Reference Transcript
RefSeq:NM_001179157.1 RPN1
Other Identifiers
1776734_at
4501_at
856422
GO:0000502
GO:0003674
GO:0004175
GO:0005515
GO:0005575
GO:0005634
GO:0005737
GO:0005783
GO:0006511
GO:0008150
GO:0008233
GO:0008540
GO:0012505
GO:0016787
GO:0030234
GO:0030674
GO:0034515
GO:0042176
GO:0043161
GO:0051603
Participates
as a component of
PSMD5:PSMC2:PSMC1:PSMD2 [cytosol] (Saccharomyces cerevisiae)
PSMC2:PSMC1:PSMD2 [cytosol] (Saccharomyces cerevisiae)
Other forms of this molecule
RPN1 [secretory granule lumen]
RPN1 [extracellular region]
RPN1 [ficolin-1-rich granule lumen]
Inferred From
PSMD2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_011892.1
ENSEMBL
YHR027C_mRNA
PRO
P38764
PDB
2NBW
,
6J30
,
3JCP
,
5MPB
,
5MPC
,
4CR4
,
6J2C
,
6J2N
,
4CR3
,
3JCO
,
7QO5
,
5WVI
,
7QO6
,
4CR2
,
7QO3
,
6J2X
,
5MPD
,
5MPE
,
6J2Q
,
6FVV
,
6FVW
,
5WVK
,
7QO4
,
5A5B
,
6FVY
,
6FVX
,
6FVU
,
6FVT
,
2N3V
,
2N3T
,
2N3U
,
2N3W
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P33299
4
PSMC2 [cytosol]
(R-SCE-68771)
PSMC2 [secretory granule lumen]
(R-SCE-6800994)
PSMC2 [extracellular region]
(R-SCE-6806472)
PSMC2 [ficolin-1-rich granule lumen]
(R-SCE-6800421)
0.952
39
UniProt:P40327
1
PSMC1 [cytosol]
(R-SCE-68768)
0.88
33
UniProt:P33298
1
PSMC4 [cytosol]
(R-SCE-68777)
0.857
24
UniProt:Q12250
4
RPN5 [cytosol]
(R-SCE-68792)
RPN5 [secretory granule lumen]
(R-SCE-6800934)
RPN5 [extracellular region]
(R-SCE-6806480)
RPN5 [ficolin-1-rich granule lumen]
(R-SCE-6800416)
0.857
29
UniProt:Q01939
1
PSMC5 [cytosol]
(R-SCE-68780)
0.822
34
UniProt:P43588
4
PSMD14 [cytosol]
(R-SCE-68722)
PSMD14 [secretory granule lumen]
(R-SCE-6800926)
PSMD14 [extracellular region]
(R-SCE-6806511)
PSMD14 [ficolin-1-rich granule lumen]
(R-SCE-6800419)
0.813
23
UniProt:P53549
1
PSMC6 [cytosol]
(R-SCE-68783)
0.813
21
UniProt:Q08723
4
RPN8 [cytosol]
(R-SCE-68806)
RPN8 [secretory granule lumen]
(R-SCE-6801008)
RPN8 [extracellular region]
(R-SCE-6806488)
RPN8 [ficolin-1-rich granule lumen]
(R-SCE-6800406)
0.813
25
UniProt:P32496
1
RPN12 [cytosol]
(R-SCE-68808)
0.813
18
UniProt:Q04062
4
RPN9 [cytosol]
(R-SCE-68794)
RPN9 [secretory granule lumen]
(R-SCE-6800983)
RPN9 [extracellular region]
(R-SCE-6806469)
RPN9 [ficolin-1-rich granule lumen]
(R-SCE-6800413)
0.813
20
UniProt:Q12377
4
RPN6 [cytosol]
(R-SCE-68790)
RPN6 [secretory granule lumen]
(R-SCE-6800943)
RPN6 [extracellular region]
(R-SCE-6806441)
RPN6 [ficolin-1-rich granule lumen]
(R-SCE-6800436)
0.813
29
UniProt:P33297
4
PSMC3 [cytosol]
(R-SCE-68774)
PSMC3 [secretory granule lumen]
(R-SCE-6800917)
PSMC3 [extracellular region]
(R-SCE-6806496)
PSMC3 [ficolin-1-rich granule lumen]
(R-SCE-6800429)
0.809
17
UniProt:P43593
1
UBP6 [cytosol]
(R-SCE-5689541)
0.758
30
UniProt:P02829
11
HSP90AA1 [cytosol]
(R-SCE-192864)
HSP90AB1 [nucleoplasm]
(R-SCE-5082399)
HSP90AA1 [nucleoplasm]
(R-SCE-5082401)
HSP90AB1 [cytosol]
(R-SCE-419617)
HSP90AA1 [plasma membrane]
(R-SCE-534996)
HSP90AA1 [secretory granule lumen]
(R-SCE-6801515)
HSP90AB1 [secretory granule lumen]
(R-SCE-6801477)
HSP90AA1 [extracellular region]
(R-SCE-3221946)
HSP90AB1 [extracellular region]
(R-SCE-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-SCE-6801491)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-SCE-6801470)
0.564
2
UniProt:Q01477
2
UBP3 [nucleoplasm]
(R-SCE-3222218)
UBP3 [cytosol]
(R-SCE-6782974)
0.527
2
UniProt:P10592
20
SSA2 [cytosol]
(R-SCE-264476)
SSA2 [nucleoplasm]
(R-SCE-5082380)
SSA2 [cytosol]
(R-SCE-3371410-3)
SSA2 [cytosol]
(R-SCE-3371408-3)
SSA2 [cytosol]
(R-SCE-6792602-3)
SSA2 [secretory granule lumen]
(R-SCE-6801530)
SSA2 [secretory granule lumen]
(R-SCE-6801472-3)
SSA2 [extracellular region]
(R-SCE-6806500-3)
SSA2 [extracellular region]
(R-SCE-6805936)
SSA2 [ficolin-1-rich granule lumen]
(R-SCE-6801512-3)
SSA2 [ficolin-1-rich granule lumen]
(R-SCE-6801496-3)
SSA2 [ficolin-1-rich granule lumen]
(R-SCE-6801494)
SSA2 [extracellular region]
(R-SCE-6805872-3)
SSA2 [nucleoplasm]
(R-SCE-6792605-3)
SSA2 [nucleoplasm]
(R-SCE-912480-3)
SSA2 [nucleoplasm]
(R-SCE-5082367-3)
SSA2 [nucleoplasm]
(R-SCE-5252082-3)
SSA2 [nucleoplasm]
(R-SCE-5252088-3)
SSA2 [nucleoplasm]
(R-SCE-5252009-3)
SSA2 [cytosol]
(R-SCE-5251948-3)
0.527
2
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