Reactome | RPL4B [cytosol]

RPL4B [cytosol]

Stable Identifier

R-SCE-72474-2

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

RPL4, P49626

Locations in the PathwayBrowser

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Metabolism of RNA (Saccharomyces cerevisiae)

- Nonsense-Mediated Decay (NMD) (Saccharomyces cerevisiae)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Saccharomyces cerevisiae)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        80S ribosome [cytosol] (Saccharomyces cerevisiae)
        
        60S ribosomal complex [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of RPL4 [cytosol] (Saccharomyces cerevisiae)
        
        RPL4B [cytosol] (Saccharomyces cerevisiae)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        80S ribosome [cytosol] (Saccharomyces cerevisiae)
        
        60S ribosomal complex [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of RPL4 [cytosol] (Saccharomyces cerevisiae)
        
        RPL4B [cytosol] (Saccharomyces cerevisiae)
    - SMG6 hydrolyzes mRNA with premature termination codon (Saccharomyces cerevisiae)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        80S ribosome [cytosol] (Saccharomyces cerevisiae)
        
        60S ribosomal complex [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of RPL4 [cytosol] (Saccharomyces cerevisiae)
        
        RPL4B [cytosol] (Saccharomyces cerevisiae)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Saccharomyces cerevisiae)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        80S ribosome [cytosol] (Saccharomyces cerevisiae)
        
        60S ribosomal complex [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of RPL4 [cytosol] (Saccharomyces cerevisiae)
        
        RPL4B [cytosol] (Saccharomyces cerevisiae)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        80S ribosome [cytosol] (Saccharomyces cerevisiae)
        
        60S ribosomal complex [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of RPL4 [cytosol] (Saccharomyces cerevisiae)
        
        RPL4B [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P49626 RPL4B

Gene Names

RPL4B, RPL2B, YDR012W, YD8119.17

Chain

initiator methionine:, chain:2-362

Reference Genes

BioGPS Gene:851575 RPL4B

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YDR012W RPL4B

Monarch:851575 RPL4B

NCBI Gene:851575 RPL4B

Reference Transcript

RefSeq:NM_001180320.3 RPL4B

Other Identifiers

1772875_at

1778730_s_at

6473_i_at

7345_s_at

851575

GO:0002181

GO:0003674

GO:0003723

GO:0003735

GO:0005198

GO:0005575

GO:0005634

GO:0005737

GO:0005829

GO:0005840

GO:0006412

GO:0008150

GO:0022625

GO:1990904

Participates

as a member of

Homologues of RPL4 [cytosol] (Saccharomyces cerevisiae)

Other forms of this molecule

RPL4B [cytosol]

Inferred From

RPL4 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_010295.3

PRO

P49626

PDB

4V4B, 2WWA, 2WW9, 2WWB

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12499 NOP58	3	NOP58 [nucleoplasm] (R-SCE-4570488) NOP58 [nucleoplasm] (R-SCE-4570470) NOP58 [nucleoplasm] (R-SCE-6790715)	0.527	2

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