Reactome | TIF4631 [cytosol]

TIF4631 [cytosol]

Stable Identifier

R-SCE-72584

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

EIF4G1, P39935

Locations in the PathwayBrowser

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Metabolism of RNA (Saccharomyces cerevisiae)

- Deadenylation-dependent mRNA decay (Saccharomyces cerevisiae)
  - Deadenylation of mRNA (Saccharomyces cerevisiae)
    - PAN2-PAN3 complex partially deadenylates mRNA (Saccharomyces cerevisiae)
      - Partially Deadenylated mRNA Complex [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of EIF4G1 [cytosol] (Saccharomyces cerevisiae)
        
        TIF4631 [cytosol] (Saccharomyces cerevisiae)
      - Translatable mRNA Complex [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of EIF4G1 [cytosol] (Saccharomyces cerevisiae)
        
        TIF4631 [cytosol] (Saccharomyces cerevisiae)
- Nonsense-Mediated Decay (NMD) (Saccharomyces cerevisiae)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
    - Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Saccharomyces cerevisiae)
      - Homologues of EIF4G1 [cytosol] (Saccharomyces cerevisiae)
        
        TIF4631 [cytosol] (Saccharomyces cerevisiae)
      - mRNA Cleaved by SMG6 [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of EIF4G1 [cytosol] (Saccharomyces cerevisiae)
        
        TIF4631 [cytosol] (Saccharomyces cerevisiae)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Saccharomyces cerevisiae)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of EIF4G1 [cytosol] (Saccharomyces cerevisiae)
        
        TIF4631 [cytosol] (Saccharomyces cerevisiae)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of EIF4G1 [cytosol] (Saccharomyces cerevisiae)
        
        TIF4631 [cytosol] (Saccharomyces cerevisiae)
    - SMG6 hydrolyzes mRNA with premature termination codon (Saccharomyces cerevisiae)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of EIF4G1 [cytosol] (Saccharomyces cerevisiae)
        
        TIF4631 [cytosol] (Saccharomyces cerevisiae)
      - mRNA Cleaved by SMG6 [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of EIF4G1 [cytosol] (Saccharomyces cerevisiae)
        
        TIF4631 [cytosol] (Saccharomyces cerevisiae)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Saccharomyces cerevisiae)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of EIF4G1 [cytosol] (Saccharomyces cerevisiae)
        
        TIF4631 [cytosol] (Saccharomyces cerevisiae)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of EIF4G1 [cytosol] (Saccharomyces cerevisiae)
        
        TIF4631 [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P39935

Gene Names

TIF4631

Reference Genes

BioGPS Gene:853071 TIF4631

ENSEMBL:YGR162W

KEGG:sce:YGR162W TIF4631

Monarch:853071 TIF4631

NCBI Gene:853071 TIF4631

SGD:YGR162W

UCSC:P39935 TIF4631

Reference Transcript

RefSeq:NM_001181291.3 TIF4631

Other Identifiers

853071

GO:0000932

GO:0001671

GO:0003674

GO:0003723

GO:0003729

GO:0003743

GO:0005515

GO:0005737

GO:0005739

GO:0005840

GO:0006412

GO:0006413

GO:0006417

GO:0006446

GO:0008135

GO:0008150

GO:0010494

GO:0010942

GO:0016281

GO:0030674

GO:0032268

GO:0034063

GO:0042149

GO:0042273

GO:0051246

GO:0070925

GO:0140693

GO:1900103

GO:1901195

GO:1902280

Participates

as a member of

Homologues of EIF4G1 [cytosol] (Saccharomyces cerevisiae)

Other forms of this molecule

phospho-TIF4631 [cytosol]

Inferred From

EIF4G1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_011678.3

ENSEMBL

YGR162W, YGR162W, YGR162W_mRNA

PRO

P39935

PDB

2VSO, 6Z29, 2VSX, 1RF8

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07260	1	CDC33 [cytosol] (R-SCE-72578)	0.965	31
UniProt:P33322	1	CBF5 [nucleoplasm] (R-SCE-163102)	0.69	5
UniProt:P02309	13	HHF1; HHF2 [nucleoplasm] (R-SCE-181902) HHF1; HHF2 [nucleoplasm] (R-SCE-5651652) HHF1; HHF2 [nucleoplasm] (R-SCE-4568758) HHF1; HHF2 [nucleoplasm] (R-SCE-4568748) HHF1; HHF2 [nucleoplasm] (R-SCE-427469) HHF1; HHF2 [nucleoplasm] (R-SCE-3451124) HHF1; HHF2 [nucleoplasm] (R-SCE-5423110) HHF1; HHF2 [nucleoplasm] (R-SCE-5651656) HHF1; HHF2 [nucleoplasm] (R-SCE-4754240) HHF1; HHF2 [nucleoplasm] (R-SCE-4754243) HHF1; HHF2 [nucleoplasm] (R-SCE-5229015) HHF1; HHF2 [nucleoplasm] (R-SCE-212078) HHF1; HHF2 [nucleoplasm] (R-SCE-4570518)	0.527	2
UniProt:P32589	5	SSE1 [nucleoplasm] (R-SCE-5252053) SSE1 [nucleoplasm] (R-SCE-5251998) SSE1 [cytosol] (R-SCE-5251943) SSE1 [cytosol] (R-SCE-5251946) SSE1 [cytosol] (R-SCE-3299412)	0.527	2
UniProt:P22147 XRN1	2	XRN1 [cytosol] (R-SCE-429835) XRN1_YEAST [cytosol] (R-SCE-429980)	0.527	3
UniProt:P02994	6	TEF1; TEF2 [cytosol] (R-SCE-156905) TEF1; TEF2 [secretory granule lumen] (R-SCE-6801479) TEF1; TEF2 [extracellular region] (R-SCE-6806456) TEF1; TEF2 [ficolin-1-rich granule lumen] (R-SCE-6801528) TEF1; TEF2 [cytosol] (R-SCE-8932419) TEF1; TEF2 [cytosol] (R-SCE-8932212)	0.527	2

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