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TIF4631 [cytosol]
Stable Identifier
R-SCE-72584
Type
Protein [EntityWithAccessionedSequence]
Species
Saccharomyces cerevisiae
Compartment
cytosol
Synonyms
EIF4G1, P39935
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Saccharomyces cerevisiae)
Deadenylation-dependent mRNA decay (Saccharomyces cerevisiae)
Deadenylation of mRNA (Saccharomyces cerevisiae)
PAN2-PAN3 complex partially deadenylates mRNA (Saccharomyces cerevisiae)
Partially Deadenylated mRNA Complex [cytosol] (Saccharomyces cerevisiae)
TIF4631 [cytosol] (Saccharomyces cerevisiae)
Translatable mRNA Complex [cytosol] (Saccharomyces cerevisiae)
TIF4631 [cytosol] (Saccharomyces cerevisiae)
Nonsense-Mediated Decay (NMD) (Saccharomyces cerevisiae)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Saccharomyces cerevisiae)
TIF4631 [cytosol] (Saccharomyces cerevisiae)
mRNA Cleaved by SMG6 [cytosol] (Saccharomyces cerevisiae)
TIF4631 [cytosol] (Saccharomyces cerevisiae)
SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Saccharomyces cerevisiae)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
TIF4631 [cytosol] (Saccharomyces cerevisiae)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
TIF4631 [cytosol] (Saccharomyces cerevisiae)
SMG6 hydrolyzes mRNA with premature termination codon (Saccharomyces cerevisiae)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
TIF4631 [cytosol] (Saccharomyces cerevisiae)
mRNA Cleaved by SMG6 [cytosol] (Saccharomyces cerevisiae)
TIF4631 [cytosol] (Saccharomyces cerevisiae)
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Saccharomyces cerevisiae)
Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
TIF4631 [cytosol] (Saccharomyces cerevisiae)
UPF1:eRF3 Complex on Translated mRNA [cytosol] (Saccharomyces cerevisiae)
Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
TIF4631 [cytosol] (Saccharomyces cerevisiae)
Metabolism of proteins (Saccharomyces cerevisiae)
Translation (Saccharomyces cerevisiae)
Eukaryotic Translation Initiation (Saccharomyces cerevisiae)
Cap-dependent Translation Initiation (Saccharomyces cerevisiae)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Saccharomyces cerevisiae)
Cap-bound mRNA is activated by helicases (Saccharomyces cerevisiae)
eIF4F:mRNP [cytosol] (Saccharomyces cerevisiae)
eIF4F [cytosol] (Saccharomyces cerevisiae)
TIF4631 [cytosol] (Saccharomyces cerevisiae)
mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Saccharomyces cerevisiae)
eIF4F [cytosol] (Saccharomyces cerevisiae)
TIF4631 [cytosol] (Saccharomyces cerevisiae)
Formation of the cap-binding eIF4F complex (Saccharomyces cerevisiae)
TIF4631 [cytosol] (Saccharomyces cerevisiae)
eIF4F [cytosol] (Saccharomyces cerevisiae)
TIF4631 [cytosol] (Saccharomyces cerevisiae)
Translation initiation complex formation (Saccharomyces cerevisiae)
Formation of translation initiation complexes containing mRNA that does not circularize (Saccharomyces cerevisiae)
48S complex [cytosol] (Saccharomyces cerevisiae)
eIF4F [cytosol] (Saccharomyces cerevisiae)
TIF4631 [cytosol] (Saccharomyces cerevisiae)
mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Saccharomyces cerevisiae)
eIF4F [cytosol] (Saccharomyces cerevisiae)
TIF4631 [cytosol] (Saccharomyces cerevisiae)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Saccharomyces cerevisiae)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Saccharomyces cerevisiae)
eIF4F [cytosol] (Saccharomyces cerevisiae)
TIF4631 [cytosol] (Saccharomyces cerevisiae)
Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Saccharomyces cerevisiae)
eIF4F [cytosol] (Saccharomyces cerevisiae)
TIF4631 [cytosol] (Saccharomyces cerevisiae)
Ribosomal scanning and start codon recognition (Saccharomyces cerevisiae)
Ribosomal scanning (Saccharomyces cerevisiae)
48S complex [cytosol] (Saccharomyces cerevisiae)
eIF4F [cytosol] (Saccharomyces cerevisiae)
TIF4631 [cytosol] (Saccharomyces cerevisiae)
Start codon recognition (Saccharomyces cerevisiae)
48S complex [cytosol] (Saccharomyces cerevisiae)
eIF4F [cytosol] (Saccharomyces cerevisiae)
TIF4631 [cytosol] (Saccharomyces cerevisiae)
L13a-mediated translational silencing of Ceruloplasmin expression (Saccharomyces cerevisiae)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Saccharomyces cerevisiae)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Saccharomyces cerevisiae)
eIF4F [cytosol] (Saccharomyces cerevisiae)
TIF4631 [cytosol] (Saccharomyces cerevisiae)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Saccharomyces cerevisiae)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Saccharomyces cerevisiae)
eIF4F [cytosol] (Saccharomyces cerevisiae)
TIF4631 [cytosol] (Saccharomyces cerevisiae)
Signal Transduction (Saccharomyces cerevisiae)
MTOR signalling (Saccharomyces cerevisiae)
mTORC1-mediated signalling (Saccharomyces cerevisiae)
Phosphorylation and activation of eIF4G by activated S6K1 (Saccharomyces cerevisiae)
TIF4631 [cytosol] (Saccharomyces cerevisiae)
External Reference Information
External Reference
UniProt:P39935
Gene Names
TIF4631
Reference Genes
BioGPS Gene:853071 TIF4631
ENSEMBL:YGR162W
KEGG:sce:YGR162W TIF4631
Monarch:853071 TIF4631
NCBI Gene:853071 TIF4631
SGD:YGR162W
UCSC:P39935 TIF4631
Reference Transcript
RefSeq:NM_001181291.3 TIF4631
Other Identifiers
1774718_at
4863_at
853071
GO:0000932
GO:0001671
GO:0002181
GO:0003674
GO:0003723
GO:0003729
GO:0003743
GO:0005515
GO:0005575
GO:0005737
GO:0005739
GO:0005840
GO:0006412
GO:0006413
GO:0006417
GO:0006446
GO:0008135
GO:0008150
GO:0010494
GO:0010942
GO:0016281
GO:0023052
GO:0030674
GO:0032268
GO:0034063
GO:0042221
GO:0042273
GO:0043621
GO:0051246
GO:0070925
GO:0140693
GO:1900103
GO:1901195
Participates
as an output of
Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Saccharomyces cerevisiae)
as a component of
mRNA Cleaved by SMG6 [cytosol] (Saccharomyces cerevisiae)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
eIF4F [cytosol] (Saccharomyces cerevisiae)
Partially Deadenylated mRNA Complex [cytosol] (Saccharomyces cerevisiae)
Translatable mRNA Complex [cytosol] (Saccharomyces cerevisiae)
as an input of
Formation of the cap-binding eIF4F complex (Saccharomyces cerevisiae)
Phosphorylation and activation of eIF4G by activated S6K1 (Saccharomyces cerevisiae)
Other forms of this molecule
phospho-TIF4631 [cytosol]
Inferred From
EIF4G1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_011678.3
ENSEMBL
YGR162W_mRNA
PRO
P39935
PDB
6Z29
,
1RF8
,
2VSO
,
2VSX
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P07260
1
CDC33 [cytosol]
(R-SCE-72578)
0.963
30
UniProt:P10081
2
EIF4A2 [cytosol]
(R-SCE-72575)
EIF4A1 [cytosol]
(R-SCE-72573)
0.954
20
UniProt:P04147 PABP
0.905
20
UniProt:P06634
3
DDX3X [ficolin-1-rich granule lumen]
(R-SCE-6801273)
DDX3X [extracellular region]
(R-SCE-6806507)
DDX3X [secretory granule lumen]
(R-SCE-6801275)
0.669
3
UniProt:P33322
1
CBF5 [nucleoplasm]
(R-SCE-163102)
0.592
4
UniProt:P39935
2
phospho-TIF4631 [cytosol]
(R-SCE-165762)
TIF4631 [cytosol]
(R-SCE-72584)
0.573
2
UniProt:P39936 IF4F2
0.564
4
UniProt:P38788 SSZ1
0.527
2
UniProt:P10591
17
SSA1 [cytosol]
(R-SCE-3371410-2)
SSA1 [cytosol]
(R-SCE-3371408-2)
SSA1 [cytosol]
(R-SCE-6792602-2)
SSA1 [secretory granule lumen]
(R-SCE-6801472-2)
SSA1 [extracellular region]
(R-SCE-6806500-2)
SSA1 [ficolin-1-rich granule lumen]
(R-SCE-6801512-2)
SSA1 [ficolin-1-rich granule lumen]
(R-SCE-6801496-2)
SSA1 [extracellular region]
(R-SCE-6805872-2)
SSA1 [nucleoplasm]
(R-SCE-6792605-2)
SSA1 [nucleoplasm]
(R-SCE-912480-2)
SSA1 [nucleoplasm]
(R-SCE-5082367-2)
SSA1 [nucleoplasm]
(R-SCE-5252082-2)
SSA1 [nucleoplasm]
(R-SCE-5252088-2)
SSA1 [nucleoplasm]
(R-SCE-5252009-2)
SSA1 [cytosol]
(R-SCE-5251948-2)
SSA1 [cytosol]
(R-SCE-5251981-2)
SSA1 [cytosol]
(R-SCE-3371521-2)
0.527
2
UniProt:P10592
20
SSA2 [cytosol]
(R-SCE-264476)
SSA2 [nucleoplasm]
(R-SCE-5082380)
SSA2 [cytosol]
(R-SCE-3371410-3)
SSA2 [cytosol]
(R-SCE-3371408-3)
SSA2 [cytosol]
(R-SCE-6792602-3)
SSA2 [secretory granule lumen]
(R-SCE-6801530)
SSA2 [secretory granule lumen]
(R-SCE-6801472-3)
SSA2 [extracellular region]
(R-SCE-6806500-3)
SSA2 [extracellular region]
(R-SCE-6805936)
SSA2 [ficolin-1-rich granule lumen]
(R-SCE-6801512-3)
SSA2 [ficolin-1-rich granule lumen]
(R-SCE-6801496-3)
SSA2 [ficolin-1-rich granule lumen]
(R-SCE-6801494)
SSA2 [extracellular region]
(R-SCE-6805872-3)
SSA2 [nucleoplasm]
(R-SCE-6792605-3)
SSA2 [nucleoplasm]
(R-SCE-912480-3)
SSA2 [nucleoplasm]
(R-SCE-5082367-3)
SSA2 [nucleoplasm]
(R-SCE-5252082-3)
SSA2 [nucleoplasm]
(R-SCE-5252088-3)
SSA2 [nucleoplasm]
(R-SCE-5252009-3)
SSA2 [cytosol]
(R-SCE-5251948-3)
0.527
2
UniProt:P11484
17
HSPA1L [cytosol]
(R-SCE-3371410-4)
HSPA2 [cytosol]
(R-SCE-3371408-4)
HSPA1A [cytosol]
(R-SCE-6792602-4)
HSPA6 [secretory granule lumen]
(R-SCE-6801472-4)
HSPA6 [extracellular region]
(R-SCE-6806500-4)
HSPA6 [ficolin-1-rich granule lumen]
(R-SCE-6801512-4)
HSPA1A [ficolin-1-rich granule lumen]
(R-SCE-6801496-4)
HSPA1A [extracellular region]
(R-SCE-6805872-4)
HSPA1A [nucleoplasm]
(R-SCE-6792605-4)
HSPA2 [nucleoplasm]
(R-SCE-912480-4)
HSPA1L [nucleoplasm]
(R-SCE-5082367-4)
HSPA14 [nucleoplasm]
(R-SCE-5252082-4)
HSPA6 [nucleoplasm]
(R-SCE-5252088-4)
HSPA13 [nucleoplasm]
(R-SCE-5252009-4)
HSPA14 [cytosol]
(R-SCE-5251948-4)
HSPA13 [cytosol]
(R-SCE-5251981-4)
HSPA6 [cytosol]
(R-SCE-3371521-4)
0.527
2
UniProt:P40561 SGN1
0.527
2
UniProt:P05317
1
RPP0 [cytosol]
(R-SCE-72396)
0.527
2
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