Formation of MIB complex containing the MICOS complex

Stable Identifier
R-SCE-8953627
Type
Reaction [omitted]
Species
Saccharomyces cerevisiae
Compartment
mitochondrial inner membrane
ReviewStatus
5/5
General
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PNG
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 | PPTX  | SBGN
Formation of MIB complex containing the MICOS complex
Assembly of the MICOS complex (MINOS complex) on the inner mitochondrial membrane appears to cause curvature of the inner membrane into the matrix to form invaginations known as cristae. The order of steps by which the MICOS complex assembles is unknown, however the MICOS complex is known to contain two subcomplexes: the MIC60 subcomplex and the MIC10 subcomplex which may associate via MIC19. The oxidation state of MIC19 regulates assembly of the MICOS complex (Sakowska et al. 2015). MIC12 is also required to couple the two subcomplexes (Zerbes et al. 2016, inferred from human QIL1 in Guarani et al. 2015). The MICOS complex transiently associates with the SAM and TOM complexes of the outer membrane to link the inner and outer membranes (Korner et al. 2012, Zerbes et al. 2012). Oligomerization of the MIC10 (homologous to MINOS10 in mammals) subunit within the MIC10 subcomplex is responsible for the actual curvature of the inner membrane (Barbot et al. 2015, Bohnert et al. 2015). Dimerization of the F1Fo ATP synthase occurs at the interior-most regions of the cristae to form the curvature at there (Paumard et al. 2002).
Literature References
PubMed ID Title Journal Year
11823415 The ATP synthase is involved in generating mitochondrial cristae morphology

Paumard, P, Velours, J, Soubannier, V, Vaillier, J, di Rago, JP, Coulary, B, Brèthes, D, Schaeffer, J, Mueller, DM

EMBO J. 2002
22575891 Role of MINOS in mitochondrial membrane architecture: cristae morphology and outer membrane interactions differentially depend on mitofilin domains

Stroud, DA, Zerbes, RM, van der Klei, IJ, Pfanner, N, Becker, T, von der Malsburg, K, Kram, A, Veenhuis, M, Warscheid, B, Bohnert, M, van der Laan, M, Wiedemann, N, Oeljeklaus, S

J. Mol. Biol. 2012
22496419 The C-terminal domain of Fcj1 is required for formation of crista junctions and interacts with the TOB/SAM complex in mitochondria

Rapaport, D, Vogel, F, Eydt, K, Rabl, R, Neupert, W, Körner, C, Dukanovic, J, Reichert, AS, Harner, M, Barrera, M

Mol. Biol. Cell 2012
26968360 Distinct Roles of Mic12 and Mic27 in the Mitochondrial Contact Site and Cristae Organizing System

Zerbes, RM, Bohnert, M, van der Laan, M, Pfanner, N, Höß, P

J. Mol. Biol. 2016
25955210 Central role of Mic10 in the mitochondrial contact site and cristae organizing system

Horvath, SE, Zerbes, RM, van der Klei, IJ, Kühlbrandt, W, Davies, KM, Pfanner, N, Rampelt, H, Boenke, T, Kram, A, Mühleip, AW, Veenhuis, M, Bohnert, M, Perschil, I, van der Laan, M

Cell Metab. 2015
26416881 The Oxidation Status of Mic19 Regulates MICOS Assembly

Sakowska, P, Chacinska, A, Jakobs, S, Jans, DC, Riedel, D, Mohanraj, K

Mol. Cell. Biol. 2015
25997101 QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology

Huttlin, EL, Gygi, SP, Fröhlich, F, Paulo, JA, McNeill, EM, Harper, JW, Van Vactor, D, Guarani, V

Elife 2015
25955211 Mic10 oligomerizes to bend mitochondrial inner membranes at cristae junctions

Denkert, N, Barbot, M, Meinecke, M, Kroppen, B, Jakobs, S, Hoppert, M, Schulz, C, Jans, DC

Cell Metab. 2015
Participants
Input
Output
Orthologous Events
Formation of MIB complex containing the MICOS complex causes curvature of mitochondrial inner membrane (Homo sapiens)
Authored
May, B  (2016-12-24)
Reviewed
Kozjak-Pavlovic, V  (2017-02-05)
Harper, JW  (2017-01-12)
Created
May, B  (2016-12-26)
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