Reactome | EIF4A3 [cytosol]

EIF4A3 [cytosol]

Stable Identifier

R-SCE-927868

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

Q12099

Locations in the PathwayBrowser

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Metabolism of RNA (Saccharomyces cerevisiae)

- Deadenylation-dependent mRNA decay (Saccharomyces cerevisiae)
  - Deadenylation of mRNA (Saccharomyces cerevisiae)
    - PAN2-PAN3 complex partially deadenylates mRNA (Saccharomyces cerevisiae)
      - Partially Deadenylated mRNA Complex [cytosol] (Saccharomyces cerevisiae)
        
        eIF4A [cytosol] (Saccharomyces cerevisiae)
        
        EIF4A3 [cytosol] (Saccharomyces cerevisiae)
      - Translatable mRNA Complex [cytosol] (Saccharomyces cerevisiae)
        
        eIF4A [cytosol] (Saccharomyces cerevisiae)
        
        EIF4A3 [cytosol] (Saccharomyces cerevisiae)
- Nonsense-Mediated Decay (NMD) (Saccharomyces cerevisiae)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Saccharomyces cerevisiae)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Saccharomyces cerevisiae)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Saccharomyces cerevisiae)
        
        EIF4A3 [cytosol] (Saccharomyces cerevisiae)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Saccharomyces cerevisiae)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Saccharomyces cerevisiae)
        
        EIF4A3 [cytosol] (Saccharomyces cerevisiae)
    - SMG6 hydrolyzes mRNA with premature termination codon (Saccharomyces cerevisiae)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Saccharomyces cerevisiae)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Saccharomyces cerevisiae)
        
        EIF4A3 [cytosol] (Saccharomyces cerevisiae)
- Processing of Capped Intron-Containing Pre-mRNA (Saccharomyces cerevisiae)
  - Transport of Mature Transcript to Cytoplasm (Saccharomyces cerevisiae)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Saccharomyces cerevisiae)
      - Transport of the export-competent mRNP complex through the NPC (Saccharomyces cerevisiae)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Saccharomyces cerevisiae)
        
        EJC [cytosol] (Saccharomyces cerevisiae)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Saccharomyces cerevisiae)
        
        EIF4A3 [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:Q12099

Reference Genes

BioGPS Gene:851584

ENSEMBL:YDR021W

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YDR021W

Monarch:851584

NCBI Gene:851584

SGD:YDR021W

Reference Transcript

RefSeq:NM_001180329.3

Other Identifiers

1776348_at

6436_at

851584

GO:0000166

GO:0000462

GO:0003674

GO:0003676

GO:0003723

GO:0003724

GO:0003729

GO:0004004

GO:0004386

GO:0005515

GO:0005524

GO:0005575

GO:0005634

GO:0005730

GO:0005737

GO:0006364

GO:0008150

GO:0008380

GO:0010468

GO:0010501

GO:0016787

GO:0016887

GO:0030490

GO:0030688

GO:0032040

GO:0034641

GO:0042254

GO:0042274

GO:0043167

GO:0043170

GO:0044238

GO:0071013

GO:0097078

GO:0140657

Participates

as a component of

Core Exon Junction Complex (Core EJC) [cytosol] (Saccharomyces cerevisiae)

as a member of

eIF4A [cytosol] (Saccharomyces cerevisiae)

Other forms of this molecule

EIF4A3 [nucleoplasm]

Inferred From

EIF4A3 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_010304.3

IntEnz

3.6.4.13

PRO

Q12099