CTD1-mediated formation of MCM2-7 double hexamers at the replication origins in budding yeast

Stable Identifier
R-SCE-9749401
Type
Reaction [transition]
Species
Saccharomyces cerevisiae
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
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Medium
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 | PPTX  | SBGN
CTD1-mediated formation of MCM2-7 double hexamers at the replication origins in budding yeast
Based on studies in budding yeast, after CDT1-mediated loading of the MCM2-7 complex to CDC6 bound to the ORC(1-6) complex at the replication origin and ATP-dependent release of CDT1, another complex of CDT1 and MCM2-7 is loaded, resulting in the formation of the salt-stable double hexamer of MCM2-7 (Fernández-Cid et al. 2013). MCM2-7 double hexamers are connected head-to-head via their N-terminal rings. DNA runs through a central channel in the double hexamer (Remus et al. 2009).
Literature References
PubMed ID Title Journal Year
19896182 Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing

Beuron, F, Remus, D, Tolun, G, Morris, EP, Diffley, JF, Griffith, JD

Cell 2009
23603117 An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM double-hexamer assembly

Fernández-Cid, A, Speck, C, Samel, S, Gardenal, E, Winkler, C, Riera, A, Herrera, MC, Evrin, C, Uhle, S, Tognetti, S

Mol Cell 2013
Participants
Input
Output
Orthologous Events
CDT1-mediated formation of MCM2-7 double hexamer at the replication origin (Homo sapiens)
Authored
Kusic-Tisma, J  (2021-10-27)
Created
Orlic-Milacic, M  (2021-08-02)
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