Reactome | LAT1 [mitochondrial matrix]

LAT1 [mitochondrial matrix]

Stable Identifier

R-SCE-9861664

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

mitochondrial matrix

Synonyms

LipoH2-K259-DLAT, P12695

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P12695

Gene Names

LAT1

Reference Genes

BioGPS Gene:855653 LAT1

ENSEMBL:YNL071W

KEGG:sce:YNL071W LAT1

Monarch:855653 LAT1

NCBI Gene:855653 LAT1

SGD:YNL071W

UCSC:P12695 LAT1

Reference Transcript

RefSeq:NM_001182909.3 LAT1

Other Identifiers

855653

GO:0004742

GO:0005575

GO:0005739

GO:0005759

GO:0005967

GO:0006086

GO:0006090

GO:0016407

GO:0016740

GO:0016746

GO:0032787

GO:0044281

GO:0045254

GO:0055086

Participates

as an input of

DLD dimer dehydrogenates dihydrolipoyl (Saccharomyces cerevisiae)

as an output of

DLAT trimer transfers acetyl to CoA (Saccharomyces cerevisiae)

Other forms of this molecule

LAT1 [mitochondrial matrix]

Inferred From

LipoH2-K259-DLAT [mitochondrial matrix] (Homo sapiens)

Modified Residues

Name

N6-lipoyl-L-lysine ((R)-N6-dihydrolipoyl-L-lysine residue) at 259 (in Homo sapiens)

Coordinate

259

Modification

(R)-N6-dihydrolipoyl-L-lysine residue

PsiMod Name

N6-lipoyl-L-lysine [MOD:00127]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-lipoyl-L-lysine.

Cross References

RefSeq

NP_014328.3

ENSEMBL

YNL071W, YNL071W_mRNA, YNL071W

IntEnz

2.3.1.12

PRO

P12695

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P16387	2	PDA1 [mitochondrial matrix] (R-SCE-69966) PDA1 [mitochondrial matrix] (R-SCE-8953513)	0.69	6
UniProt:P32473	1	PDB1 [mitochondrial matrix] (R-SCE-69967)	0.669	7
UniProt:P10591	20	SSA1 [cytosol] (R-SCE-264476-2) SSA1 [cytosol] (R-SCE-3371410-2) SSA1 [cytosol] (R-SCE-3371408-2) SSA1 [nucleoplasm] (R-SCE-5082380-2) SSA1 [secretory granule lumen] (R-SCE-6801472-2) SSA1 [secretory granule lumen] (R-SCE-6801530-2) SSA1 [extracellular region] (R-SCE-6805936-2) SSA1 [extracellular region] (R-SCE-6806500-2) SSA1 [ficolin-1-rich granule lumen] (R-SCE-6801512-2) SSA1 [ficolin-1-rich granule lumen] (R-SCE-6801494-2) SSA1 [nucleoplasm] (R-SCE-912480-2) SSA1 [nucleoplasm] (R-SCE-5082367-2) SSA1 [nucleoplasm] (R-SCE-5252082-2) SSA1 [nucleoplasm] (R-SCE-5252088-2) SSA1 [nucleoplasm] (R-SCE-5252009-2) SSA1 [nucleoplasm] (R-SCE-5252047-2) SSA1 [cytosol] (R-SCE-5251948-2) SSA1 [cytosol] (R-SCE-5251981-2) SSA1 [cytosol] (R-SCE-3371521-2) SSA1 [cytosol] (R-SCE-5251954-2)	0.527	2
UniProt:P10592	20	SSA2 [cytosol] (R-SCE-264476-3) SSA2 [nucleoplasm] (R-SCE-6792605) SSA2 [cytosol] (R-SCE-3371410-3) SSA2 [cytosol] (R-SCE-3371408-3) SSA2 [cytosol] (R-SCE-6792602) SSA2 [nucleoplasm] (R-SCE-5082380-3) SSA2 [secretory granule lumen] (R-SCE-6801472-3) SSA2 [secretory granule lumen] (R-SCE-6801530-3) SSA2 [extracellular region] (R-SCE-6805936-3) SSA2 [extracellular region] (R-SCE-6806500-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801496) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801512-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801494-3) SSA2 [extracellular region] (R-SCE-6805872) SSA2 [nucleoplasm] (R-SCE-912480-3) SSA2 [nucleoplasm] (R-SCE-5082367-3) SSA2 [nucleoplasm] (R-SCE-5252082-3) SSA2 [nucleoplasm] (R-SCE-5252088-3) SSA2 [nucleoplasm] (R-SCE-5252009-3) SSA2 [nucleoplasm] (R-SCE-5252047-3)	0.527	2
UniProt:P25646 PDP2			0.527	3
UniProt:P09624	1	LPD1 [mitochondrial matrix] (R-SCE-69978)	0.508	2

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