Reactome | TFIIH [nucleoplasm]

TFIIH [nucleoplasm]

Stable Identifier

R-SPO-109634

Type

Complex

Species

Schizosaccharomyces pombe

Compartment

nucleoplasm

Locations in the PathwayBrowser

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DNA Repair (Schizosaccharomyces pombe)

- Nucleotide Excision Repair (Schizosaccharomyces pombe)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Schizosaccharomyces pombe)
    - Formation of Incision Complex in GG-NER (Schizosaccharomyces pombe)
      - Recruitment of XPA and release of CAK (Schizosaccharomyces pombe)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Schizosaccharomyces pombe)
        
        TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Schizosaccharomyces pombe)
    - Dual incision in TC-NER (Schizosaccharomyces pombe)
      - 3' incision by ERCC5 (XPG) in TC-NER (Schizosaccharomyces pombe)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Schizosaccharomyces pombe)
        
        TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Schizosaccharomyces pombe)
        
        TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
      - 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Schizosaccharomyces pombe)
        
        TC-NER incision complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Schizosaccharomyces pombe)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
        
        TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Schizosaccharomyces pombe)
        
        TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
      - Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Schizosaccharomyces pombe)
        
        TC-NER incision complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Schizosaccharomyces pombe)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
        
        TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Schizosaccharomyces pombe)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
        
        TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
      - DNA polymerases delta, epsilon or kappa bind the TC-NER site (Schizosaccharomyces pombe)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Schizosaccharomyces pombe)
        
        TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Schizosaccharomyces pombe)
        
        TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
      - ERCC2-facilitated RNA Pol II backtracking in TC-NER (Schizosaccharomyces pombe)
        
        TC-NER pre-incision complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
        
        TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
        
        TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
      - ERCC3-facilitated RNA Pol II backtracking in TC-NER (Schizosaccharomyces pombe)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
        
        TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
        
        TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
      - ERCC5 and RPA bind TC-NER site (Schizosaccharomyces pombe)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Schizosaccharomyces pombe)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
        
        TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
        
        TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
    - Formation of TC-NER Pre-Incision Complex (Schizosaccharomyces pombe)
      - Active RNA Pol II complex transcribes lesion-containing DNA template (Schizosaccharomyces pombe)
        
        Damaged dsDNA with open transcription bubble:Hyperphosphorylated RNA Pol II:TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
        
        TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
        
        TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
      - ERCC6 binds stalled RNA Pol II (Schizosaccharomyces pombe)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
        
        TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
        
        TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
      - ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Schizosaccharomyces pombe)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
        
        TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
        
        TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
      - RNA Pol II initiates transcription from damaged DNA template (Schizosaccharomyces pombe)
        
        Damaged dsDNA with open transcription bubble:Hyperphosphorylated RNA Pol II:TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
        
        TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
        
        TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
      - UVSSA:USP7 deubiquitinates ERCC6 (Schizosaccharomyces pombe)
        
        TC-NER pre-incision complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
        
        TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
        
        TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
    - Gap-filling DNA repair synthesis and ligation in TC-NER (Schizosaccharomyces pombe)
      - Ligation of newly synthesized repair patch to incised DNA in TC-NER (Schizosaccharomyces pombe)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Schizosaccharomyces pombe)
        
        TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
        
        TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Schizosaccharomyces pombe)
        
        TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Schizosaccharomyces pombe)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Schizosaccharomyces pombe)
        
        TFIIH [nucleoplasm] (Schizosaccharomyces pombe)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Schizosaccharomyces pombe)
        
        TFIIH [nucleoplasm] (Schizosaccharomyces pombe)

General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

Participates

as a component of

as an input of

as an output of

Inferred From

TFIIH [nucleoplasm] (Homo sapiens)

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