Reactome | mnh1 [nucleoplasm]

mnh1 [nucleoplasm]

Stable Identifier

R-SPO-156658

Type

Protein [EntityWithAccessionedSequence]

Species

Schizosaccharomyces pombe

Compartment

nucleoplasm

Synonyms

MAGOH, O43037

Locations in the PathwayBrowser

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Metabolism of RNA (Schizosaccharomyces pombe)

- Nonsense-Mediated Decay (NMD) (Schizosaccharomyces pombe)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Schizosaccharomyces pombe)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Schizosaccharomyces pombe)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Schizosaccharomyces pombe)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Schizosaccharomyces pombe)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Schizosaccharomyces pombe)
        
        Magoh-Y14 complex [cytosol] (Schizosaccharomyces pombe)
        
        mnh1 [nucleoplasm] (Schizosaccharomyces pombe)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Schizosaccharomyces pombe)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Schizosaccharomyces pombe)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Schizosaccharomyces pombe)
        
        Magoh-Y14 complex [cytosol] (Schizosaccharomyces pombe)
        
        mnh1 [nucleoplasm] (Schizosaccharomyces pombe)
    - SMG6 hydrolyzes mRNA with premature termination codon (Schizosaccharomyces pombe)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Schizosaccharomyces pombe)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Schizosaccharomyces pombe)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Schizosaccharomyces pombe)
        
        Magoh-Y14 complex [cytosol] (Schizosaccharomyces pombe)
        
        mnh1 [nucleoplasm] (Schizosaccharomyces pombe)
- Processing of Capped Intron-Containing Pre-mRNA (Schizosaccharomyces pombe)
  - Transport of Mature Transcript to Cytoplasm (Schizosaccharomyces pombe)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Schizosaccharomyces pombe)
      - Transport of the export-competent mRNP complex through the NPC (Schizosaccharomyces pombe)
        
        NPC:NXF1,2:NXT1:EJC:CBC:mRNA [nucleoplasm] (Schizosaccharomyces pombe)
        
        EJC [nucleoplasm] (Schizosaccharomyces pombe)
        
        Core EJC [nucleoplasm] (Schizosaccharomyces pombe)
        
        Magoh-Y14 complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        mnh1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Schizosaccharomyces pombe)
        
        EJC [cytosol] (Schizosaccharomyces pombe)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Schizosaccharomyces pombe)
        
        Magoh-Y14 complex [cytosol] (Schizosaccharomyces pombe)
        
        mnh1 [nucleoplasm] (Schizosaccharomyces pombe)
      - mRNP complex dissociates from cytosolic face of NPC (Schizosaccharomyces pombe)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Schizosaccharomyces pombe)
        
        EJC [cytosol] (Schizosaccharomyces pombe)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Schizosaccharomyces pombe)
        
        Magoh-Y14 complex [cytosol] (Schizosaccharomyces pombe)
        
        mnh1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        mRNA:CBC:EJC:POLDIP3 [cytosol] (Schizosaccharomyces pombe)
        
        EJC [cytosol] (Schizosaccharomyces pombe)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Schizosaccharomyces pombe)
        
        Magoh-Y14 complex [cytosol] (Schizosaccharomyces pombe)
        
        mnh1 [nucleoplasm] (Schizosaccharomyces pombe)

External Reference Information

External Reference

UniProt:O43037

Gene Names

mnh1

Reference Genes

BioGPS Gene:2540522 mnh1

ENSEMBL:SPBC3B9.08c

GeneDB:SPBC3B9.08c

KEGG Gene (Schizosaccharomyces pombe):SPBC3B9.08c mnh1

Monarch:2540522 mnh1

NCBI Gene:2540522 mnh1

Reference Transcript

RefSeq:NM_001022588.2 mnh1

Participates

as a component of

Other forms of this molecule

mnh1 [nucleoplasm]

Inferred From

MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)

MAGOH [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_596666.1

PRO

O43037