Reactome | clr6 [nucleoplasm]

clr6 [nucleoplasm]

Stable Identifier

R-SPO-205021

Type

Protein [EntityWithAccessionedSequence]

Species

Schizosaccharomyces pombe

Compartment

nucleoplasm

Synonyms

HDAC1, O59702

Locations in the PathwayBrowser

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Chromatin organization (Schizosaccharomyces pombe)

- Chromatin modifying enzymes (Schizosaccharomyces pombe)
  - HDACs deacetylate histones (Schizosaccharomyces pombe)
    - HDAC1:2-containing complex binds HDAC2 Inhibitors (Schizosaccharomyces pombe)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Schizosaccharomyces pombe)
        
        Sin3A complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        Sin3a core complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        HDAC1:HDAC2 [nucleoplasm] (Schizosaccharomyces pombe)
        
        clr6 [nucleoplasm] (Schizosaccharomyces pombe)
      - Sin3A complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        Sin3a core complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        HDAC1:HDAC2 [nucleoplasm] (Schizosaccharomyces pombe)
        
        clr6 [nucleoplasm] (Schizosaccharomyces pombe)
    - HDAC1:2-containing complex deacetylate histones (Schizosaccharomyces pombe)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Schizosaccharomyces pombe)
        
        Sin3A complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        Sin3a core complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        HDAC1:HDAC2 [nucleoplasm] (Schizosaccharomyces pombe)
        
        clr6 [nucleoplasm] (Schizosaccharomyces pombe)
      - Sin3A complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        Sin3a core complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        HDAC1:HDAC2 [nucleoplasm] (Schizosaccharomyces pombe)
        
        clr6 [nucleoplasm] (Schizosaccharomyces pombe)

External Reference Information

External Reference

UniProt:O59702

Gene Names

clr6

Reference Genes

BioGPS Gene:2540368 clr6

ENSEMBL:SPBC36.05c

KEGG:spo:SPBC36.05c clr6

Monarch:2540368 clr6

NCBI Gene:2540368 clr6

PomBase:SPBC36.05c

UCSC:O59702 clr6

Reference Transcript

RefSeq:NM_001021241.2 clr6

Participates

as an input of

SUMOylation of HDAC1 with SUMO1 (Schizosaccharomyces pombe)

as a component of

Other forms of this molecule

clr6 [nucleoplasm]

Inferred From

HDAC1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_595333.1

PRO

O59702

PDB

8IFG, 8I03, 8I02

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O13919	1	pst2 [nucleoplasm] (R-SPO-349685)	0.722	7
UniProt:O14021	1	prw1 [nucleoplasm] (R-SPO-212223)	0.693	9
UniProt:O13953 EAF3			0.693	9
UniProt:Q09750	3	pst1 [nucleoplasm] (R-SPO-4086071) pst1 [nucleoplasm] (R-SPO-351657) pst1 [nucleoplasm] (R-SPO-349685-3)	0.623	5
UniProt:Q9UTB6	2	sds3 [nucleoplasm] (R-SPO-6782790-2) sds3 [nucleoplasm] (R-SPO-351696-2)	0.499	5
UniProt:Q09819 YAC5			0.499	2
UniProt:O74736	4	monoSUMO1-K195-ING2 [nucleoplasm] (R-SPO-4086075-2) ING4 [nucleoplasm] (R-SPO-3215153-2) ING2 [nucleoplasm] (R-SPO-3215167-2) ING5 [nucleoplasm] (R-SPO-3215169-2)	0.499	3