Reactome | hht1 [nucleoplasm]

hht1 [nucleoplasm]

Stable Identifier

R-SPO-212295

Type

Protein [EntityWithAccessionedSequence]

Species

Schizosaccharomyces pombe

Compartment

nucleoplasm

Synonyms

H3F3A, P09988

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Schizosaccharomyces pombe)

- Cellular responses to stress (Schizosaccharomyces pombe)
  - Cellular Senescence (Schizosaccharomyces pombe)
    - Oxidative Stress Induced Senescence (Schizosaccharomyces pombe)
      - KDM6B demethylates H3K27me3 on p16INK4A promoter (Schizosaccharomyces pombe)
        
        CDKN2A Gene:Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        Histone H3 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of H3F3A [nucleoplasm] (Schizosaccharomyces pombe)
        
        hht1 [nucleoplasm] (Schizosaccharomyces pombe)

DNA Replication (Schizosaccharomyces pombe)

- DNA Replication Pre-Initiation (Schizosaccharomyces pombe)
  - Assembly of the pre-replicative complex (Schizosaccharomyces pombe)
    - Assembly of the ORC complex at the origin of replication (Schizosaccharomyces pombe)
      - ORC1 binds to H4K20me2 (Schizosaccharomyces pombe)
        
        H4K20Me2-nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        Histone H3 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of H3F3A [nucleoplasm] (Schizosaccharomyces pombe)
        
        hht1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        ORC1:H4K20Me2-nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        H4K20Me2-nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        Histone H3 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of H3F3A [nucleoplasm] (Schizosaccharomyces pombe)
        
        hht1 [nucleoplasm] (Schizosaccharomyces pombe)

Gene expression (Transcription) (Schizosaccharomyces pombe)

- Epigenetic regulation of gene expression (Schizosaccharomyces pombe)
  - Negative epigenetic regulation of rRNA expression (Schizosaccharomyces pombe)
    - SIRT1 negatively regulates rRNA expression (Schizosaccharomyces pombe)
      - eNoSC deacetylates histone H3 (Schizosaccharomyces pombe)
        
        Chromatin [nucleoplasm] (Schizosaccharomyces pombe)
        
        Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        Histone H3 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of H3F3A [nucleoplasm] (Schizosaccharomyces pombe)
        
        hht1 [nucleoplasm] (Schizosaccharomyces pombe)
      - eNoSC dimethylates histone H3 at lysine-9 (Schizosaccharomyces pombe)
        
        Chromatin [nucleoplasm] (Schizosaccharomyces pombe)
        
        Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        Histone H3 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of H3F3A [nucleoplasm] (Schizosaccharomyces pombe)
        
        hht1 [nucleoplasm] (Schizosaccharomyces pombe)
- Gene Silencing by RNA (Schizosaccharomyces pombe)
  - Transcriptional regulation by small RNAs (Schizosaccharomyces pombe)
    - AGO1,2:small RNA complexes interact with chromatin (Schizosaccharomyces pombe)
      - AGO1,2:miRNA:chromatin:RNA pol II [nucleoplasm] (Schizosaccharomyces pombe)
        
        Chromatin [nucleoplasm] (Schizosaccharomyces pombe)
        
        Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        Histone H3 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of H3F3A [nucleoplasm] (Schizosaccharomyces pombe)
        
        hht1 [nucleoplasm] (Schizosaccharomyces pombe)
      - Chromatin [nucleoplasm] (Schizosaccharomyces pombe)
        
        Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        Histone H3 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of H3F3A [nucleoplasm] (Schizosaccharomyces pombe)
        
        hht1 [nucleoplasm] (Schizosaccharomyces pombe)

Signal Transduction (Schizosaccharomyces pombe)

- Signaling by Nuclear Receptors (Schizosaccharomyces pombe)
  - ESR-mediated signaling (Schizosaccharomyces pombe)
    - Estrogen-dependent gene expression (Schizosaccharomyces pombe)
      - KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Schizosaccharomyces pombe)
        
        MYC gene, BCL2 gene:HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Schizosaccharomyces pombe)
        
        HIST1H2AC nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        Histone H3 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of H3F3A [nucleoplasm] (Schizosaccharomyces pombe)
        
        hht1 [nucleoplasm] (Schizosaccharomyces pombe)

External Reference Information

External Reference

UniProt:P09988

Gene Names

hht1

Reference Genes

BioGPS Gene:2539804 hht1

BioGPS Gene:2541220 hht1

BioGPS Gene:2542467 hht1

ENSEMBL:SPAC1834.04

GeneDB:SPAC1834.04

KEGG Gene (Schizosaccharomyces pombe):SPAC1834.04 hht1

KEGG Gene (Schizosaccharomyces pombe):SPBC1105.11c hht1

KEGG Gene (Schizosaccharomyces pombe):SPBC8D2.04 hht1

Monarch:2539804 hht1

Monarch:2541220 hht1

Monarch:2542467 hht1

NCBI Gene:2539804 hht1

NCBI Gene:2541220 hht1

NCBI Gene:2542467 hht1

Reference Transcript

Participates

as a member of

Homologues of H3F3A [nucleoplasm] (Schizosaccharomyces pombe)

Other forms of this molecule

hht1 [nucleoplasm]

phospho-hht1 [nucleoplasm]

hht1 [nucleoplasm]

phospho-hht1 [nucleoplasm]

hht1 [nucleoplasm]

Inferred From

H3F3A [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_596467.1, NP_594683.1, NP_595567.1

PRO

P09988

PDB

3G7L, 2DZE