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FEN1 [nucleoplasm]
Stable Identifier
R-SPO-54745
Type
Protein [EntityWithAccessionedSequence]
Species
Schizosaccharomyces pombe
Compartment
nucleoplasm
Synonyms
P39750
Locations in the PathwayBrowser
Expand all
Cell Cycle (Schizosaccharomyces pombe)
Cell Cycle, Mitotic (Schizosaccharomyces pombe)
S Phase (Schizosaccharomyces pombe)
Synthesis of DNA (Schizosaccharomyces pombe)
DNA strand elongation (Schizosaccharomyces pombe)
Lagging Strand Synthesis (Schizosaccharomyces pombe)
Processive synthesis on the lagging strand (Schizosaccharomyces pombe)
Removal of the Flap Intermediate (Schizosaccharomyces pombe)
Removal of remaining Flap (Schizosaccharomyces pombe)
FEN1 [nucleoplasm] (Schizosaccharomyces pombe)
DNA Repair (Schizosaccharomyces pombe)
Base Excision Repair (Schizosaccharomyces pombe)
Resolution of Abasic Sites (AP sites) (Schizosaccharomyces pombe)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Schizosaccharomyces pombe)
PCNA-Dependent Long Patch Base Excision Repair (Schizosaccharomyces pombe)
POLD,POLE-mediated DNA strand displacement synthesis (Schizosaccharomyces pombe)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Schizosaccharomyces pombe)
FEN1 [nucleoplasm] (Schizosaccharomyces pombe)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Schizosaccharomyces pombe)
FEN1 [nucleoplasm] (Schizosaccharomyces pombe)
DNA Double-Strand Break Repair (Schizosaccharomyces pombe)
Homology Directed Repair (Schizosaccharomyces pombe)
HDR through MMEJ (alt-NHEJ) (Schizosaccharomyces pombe)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Schizosaccharomyces pombe)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm] (Schizosaccharomyces pombe)
FEN1 [nucleoplasm] (Schizosaccharomyces pombe)
FEN1 [nucleoplasm] (Schizosaccharomyces pombe)
DNA Replication (Schizosaccharomyces pombe)
Synthesis of DNA (Schizosaccharomyces pombe)
DNA strand elongation (Schizosaccharomyces pombe)
Lagging Strand Synthesis (Schizosaccharomyces pombe)
Processive synthesis on the lagging strand (Schizosaccharomyces pombe)
Removal of the Flap Intermediate (Schizosaccharomyces pombe)
Removal of remaining Flap (Schizosaccharomyces pombe)
FEN1 [nucleoplasm] (Schizosaccharomyces pombe)
External Reference Information
External Reference
UniProt:P39750
Reference Genes
BioGPS Gene:2543164
ENSEMBL:SPAC3G6.06c
KEGG:spo:SPAC3G6.06c
Monarch:2543164
NCBI Gene:2543164
PomBase:SPAC3G6.06c
UCSC:P39750
Reference Transcript
RefSeq:NM_001020403.2
Participates
as a component of
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Schizosaccharomyces pombe)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Schizosaccharomyces pombe)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm] (Schizosaccharomyces pombe)
as an output of
FEN1 cleaves displaced ssDNA flaps during MMEJ (Schizosaccharomyces pombe)
Inferred From
FEN1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_594972.1
PRO
P39750
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