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ORC4 [nucleoplasm]
Stable Identifier
R-SPO-68519
Type
Protein [EntityWithAccessionedSequence]
Species
Schizosaccharomyces pombe
Compartment
nucleoplasm
Synonyms
Q9Y794
Locations in the PathwayBrowser
Expand all
Cell Cycle (Schizosaccharomyces pombe)
Cell Cycle Checkpoints (Schizosaccharomyces pombe)
G2/M Checkpoints (Schizosaccharomyces pombe)
Activation of ATR in response to replication stress (Schizosaccharomyces pombe)
Loading of claspin onto DNA during replication origin firing (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
Cell Cycle, Mitotic (Schizosaccharomyces pombe)
Mitotic G1 phase and G1/S transition (Schizosaccharomyces pombe)
G1/S Transition (Schizosaccharomyces pombe)
Activation of the pre-replicative complex (Schizosaccharomyces pombe)
CDK and DDK associate with the Mcm10:pre-replicative complex (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
Cdc45 associates with the pre-replicative complex at the origin (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
Cdt1 is displaced from the pre-replicative complex. (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
DNA polymerase alpha:primase binds at the origin (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
DNA polymerase epsilon binds at the origin (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Schizosaccharomyces pombe)
MCM10:pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
S Phase (Schizosaccharomyces pombe)
Synthesis of DNA (Schizosaccharomyces pombe)
Switching of origins to a post-replicative state (Schizosaccharomyces pombe)
Orc1 removal from chromatin (Schizosaccharomyces pombe)
Orc1 is phosphorylated by cyclin A/CDK2 (Schizosaccharomyces pombe)
pre-replicative complex (Orc1-minus) [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
DNA Replication (Schizosaccharomyces pombe)
DNA Replication Pre-Initiation (Schizosaccharomyces pombe)
Activation of the pre-replicative complex (Schizosaccharomyces pombe)
CDK and DDK associate with the Mcm10:pre-replicative complex (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
Cdc45 associates with the pre-replicative complex at the origin (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
Cdt1 is displaced from the pre-replicative complex. (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
DNA polymerase alpha:primase binds at the origin (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
DNA polymerase epsilon binds at the origin (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Schizosaccharomyces pombe)
MCM10:pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
Assembly of the pre-replicative complex (Schizosaccharomyces pombe)
Assembly of the ORC complex at the origin of replication (Schizosaccharomyces pombe)
Formation of ORC(1-5) complex (Schizosaccharomyces pombe)
ORC(1-5):origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC(1-5) [nucleoplasm] (Schizosaccharomyces pombe)
ORC(2-5) [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
ORC(2-5) [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
Formation of ORC(1-6) complex (Schizosaccharomyces pombe)
ORC(1-5):origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC(1-5) [nucleoplasm] (Schizosaccharomyces pombe)
ORC(2-5) [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
ORC(1-6):origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC(1-5):origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC(1-5) [nucleoplasm] (Schizosaccharomyces pombe)
ORC(2-5) [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
Formation of ORC(2-5) complex (Schizosaccharomyces pombe)
ORC(2-5) [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
CDC6 association with the ORC:origin complex (Schizosaccharomyces pombe)
CDC6 association with ORC(1-6) at replication origins (Schizosaccharomyces pombe)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC(1-6):origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC(1-5):origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC(1-5) [nucleoplasm] (Schizosaccharomyces pombe)
ORC(2-5) [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
ORC(1-6):origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC(1-5):origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC(1-5) [nucleoplasm] (Schizosaccharomyces pombe)
ORC(2-5) [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
Synthesis of DNA (Schizosaccharomyces pombe)
Switching of origins to a post-replicative state (Schizosaccharomyces pombe)
Orc1 removal from chromatin (Schizosaccharomyces pombe)
Orc1 is phosphorylated by cyclin A/CDK2 (Schizosaccharomyces pombe)
pre-replicative complex (Orc1-minus) [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
ORC4 [nucleoplasm] (Schizosaccharomyces pombe)
External Reference Information
External Reference
UniProt:Q9Y794
Reference Genes
BioGPS Gene:2541298
ENSEMBL:SPBP23A10.13
GeneDB:SPBP23A10.13
KEGG Gene (Schizosaccharomyces pombe):SPBP23A10.13
Monarch:2541298
NCBI Gene:2541298
Reference Transcript
RefSeq:NM_001021729.2
Participates
as a component of
pre-replicative complex (Orc1-minus) [nucleoplasm] (Schizosaccharomyces pombe)
ORC(2-5) [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
as an input of
Formation of ORC(2-5) complex (Schizosaccharomyces pombe)
Inferred From
ORC4 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_595825.1
PRO
Q9Y794
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