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F2 [extracellular region]
Stable Identifier
R-SSC-140598
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
extracellular region
Synonyms
thrombin light chain, F1SIB1
Locations in the PathwayBrowser
Expand all
Hemostasis (Sus scrofa)
Formation of Fibrin Clot (Clotting Cascade) (Sus scrofa)
Common Pathway of Fibrin Clot Formation (Sus scrofa)
Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
factor V -> factor Va + factor V activation peptide (Sus scrofa)
Extracellular thrombin inactivating complexes [extracellular region] (Sus scrofa)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
thrombin:cleaved SERPINC1 [extracellular region] (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Sus scrofa)
Extracellular thrombin inactivating complexes [extracellular region] (Sus scrofa)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
thrombin:cleaved SERPINC1 [extracellular region] (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
Factor IIa inhibitors:IIa [extracellular region] (Sus scrofa)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Sus scrofa)
Extracellular thrombin inactivating complexes [extracellular region] (Sus scrofa)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
thrombin:cleaved SERPINC1 [extracellular region] (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
Factor IIa inhibitors:IIa [extracellular region] (Sus scrofa)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Sus scrofa)
thrombin:cleaved SERPINC1 [extracellular region] (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
Intrinsic Pathway of Fibrin Clot Formation (Sus scrofa)
Factor IIa inhibitors (compounds) binds IIa (Sus scrofa)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
Factor IIa inhibitors (peptide) binds IIa (Sus scrofa)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Sus scrofa)
Extracellular thrombin inactivating complexes [extracellular region] (Sus scrofa)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
thrombin:cleaved SERPINC1 [extracellular region] (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
Factor IIa inhibitors:IIa [extracellular region] (Sus scrofa)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
Platelet activation, signaling and aggregation (Sus scrofa)
Platelet Aggregation (Plug Formation) (Sus scrofa)
Thrombin binding to GP1b:IX:V (Sus scrofa)
GP1b-IX-V complex:activated thrombin (factor IIa) [plasma membrane] (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
Thrombin signalling through proteinase activated receptors (PARs) (Sus scrofa)
Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
Immune System (Sus scrofa)
Innate Immune System (Sus scrofa)
Complement cascade (Sus scrofa)
Regulation of Complement cascade (Sus scrofa)
Thrombin, ELANE cleave C5 (Sus scrofa)
Activated thrombin, (ELANE) [extracellular region] (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
Signal Transduction (Sus scrofa)
Signaling by GPCR (Sus scrofa)
GPCR downstream signalling (Sus scrofa)
G alpha (q) signalling events (Sus scrofa)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Sus scrofa)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Sus scrofa)
Thrombin:Proteinase-activated receptors [plasma membrane] (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Sus scrofa)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Sus scrofa)
Thrombin:Proteinase-activated receptors [plasma membrane] (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Sus scrofa)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Sus scrofa)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Sus scrofa)
Thrombin:Proteinase-activated receptors [plasma membrane] (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Sus scrofa)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Sus scrofa)
Thrombin:Proteinase-activated receptors [plasma membrane] (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
The Ligand:GPCR:Gq complex dissociates (Sus scrofa)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Sus scrofa)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Sus scrofa)
Thrombin:Proteinase-activated receptors [plasma membrane] (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
GPCR ligand binding (Sus scrofa)
Class A/1 (Rhodopsin-like receptors) (Sus scrofa)
Peptide ligand-binding receptors (Sus scrofa)
Proteinase-activated receptors can bind thrombin (Sus scrofa)
Thrombin:Proteinase-activated receptors [plasma membrane] (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
F2 [extracellular region] (Sus scrofa)
External Reference Information
External Reference
UniProt:F1SIB1
Gene Names
F2
Reference Genes
ENSEMBL:ENSSSCG00000013252.5
Other Identifiers
100144442
GO:0001530
GO:0001934
GO:0002376
GO:0003824
GO:0004175
GO:0004252
GO:0005102
GO:0005509
GO:0005576
GO:0005615
GO:0005886
GO:0006508
GO:0006953
GO:0006954
GO:0007166
GO:0007186
GO:0007596
GO:0007599
GO:0008201
GO:0008233
GO:0008236
GO:0008284
GO:0008289
GO:0008360
GO:0009611
GO:0009897
GO:0010468
GO:0016787
GO:0023052
GO:0030154
GO:0030168
GO:0030194
GO:0030307
GO:0030312
GO:0031012
GO:0032024
GO:0032967
GO:0036211
GO:0042060
GO:0042730
GO:0045861
GO:0048712
GO:0048856
GO:0051281
GO:0051480
GO:0051838
GO:0051897
GO:0055065
GO:0055085
GO:0060089
GO:0061844
GO:0062023
GO:0070053
GO:0070945
GO:0098542
GO:0140096
GO:1900016
GO:1900182
GO:1900738
GO:1990806
GO:2000379
Ssc.15302.1.S1_at
Participates
as a component of
activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
Other forms of this molecule
F2 [Golgi lumen]
F2 [Golgi lumen]
F2 [Golgi lumen]
F2 [endoplasmic reticulum lumen]
F2 [endoplasmic reticulum lumen]
F2 [plasma membrane]
F2 [plasma membrane]
F2 [extracellular region]
F2 [extracellular region]
F2 [extracellular region]
Inferred From
thrombin light chain [extracellular region]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000180210
Ensembl
ENSSSCT00000014473
,
ENSSSCG00000013252
,
ENSSSCP00000014081
VGNC
97993
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