Reactome | MAGOH [nucleoplasm]

MAGOH [nucleoplasm]

Stable Identifier

R-SSC-156658

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

F1S766

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Sus scrofa)

- RNA Polymerase II Transcription (Sus scrofa)
  - RNA Polymerase II Transcription Termination (Sus scrofa)
    - Cleavage of mRNA at the 3'-end (Sus scrofa)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Sus scrofa)
        
        EJC [nucleoplasm] (Sus scrofa)
        
        Core EJC [nucleoplasm] (Sus scrofa)
        
        Magoh-Y14 complex [nucleoplasm] (Sus scrofa)
        
        MAGOH,MAGOHB [nucleoplasm] (Sus scrofa)
        
        MAGOH [nucleoplasm] (Sus scrofa)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Sus scrofa)
        
        EJC [nucleoplasm] (Sus scrofa)
        
        Core EJC [nucleoplasm] (Sus scrofa)
        
        Magoh-Y14 complex [nucleoplasm] (Sus scrofa)
        
        MAGOH,MAGOHB [nucleoplasm] (Sus scrofa)
        
        MAGOH [nucleoplasm] (Sus scrofa)

Metabolism of RNA (Sus scrofa)

- Nonsense-Mediated Decay (NMD) (Sus scrofa)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Sus scrofa)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Sus scrofa)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Sus scrofa)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Sus scrofa)
        
        Magoh-Y14 complex [cytosol] (Sus scrofa)
        
        MAGOH,MAGOHB [nucleoplasm] (Sus scrofa)
        
        MAGOH [nucleoplasm] (Sus scrofa)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Sus scrofa)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Sus scrofa)
        
        Magoh-Y14 complex [cytosol] (Sus scrofa)
        
        MAGOH,MAGOHB [nucleoplasm] (Sus scrofa)
        
        MAGOH [nucleoplasm] (Sus scrofa)
    - SMG6 hydrolyzes mRNA with premature termination codon (Sus scrofa)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Sus scrofa)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Sus scrofa)
        
        Magoh-Y14 complex [cytosol] (Sus scrofa)
        
        MAGOH,MAGOHB [nucleoplasm] (Sus scrofa)
        
        MAGOH [nucleoplasm] (Sus scrofa)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Sus scrofa)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Sus scrofa)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Sus scrofa)
        
        Magoh-Y14 complex [cytosol] (Sus scrofa)
        
        MAGOH,MAGOHB [nucleoplasm] (Sus scrofa)
        
        MAGOH [nucleoplasm] (Sus scrofa)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Sus scrofa)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Sus scrofa)
        
        Magoh-Y14 complex [cytosol] (Sus scrofa)
        
        MAGOH,MAGOHB [nucleoplasm] (Sus scrofa)
        
        MAGOH [nucleoplasm] (Sus scrofa)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Sus scrofa)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Sus scrofa)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Sus scrofa)
        
        Magoh-Y14 complex [cytosol] (Sus scrofa)
        
        MAGOH,MAGOHB [nucleoplasm] (Sus scrofa)
        
        MAGOH [nucleoplasm] (Sus scrofa)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Sus scrofa)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Sus scrofa)
        
        Magoh-Y14 complex [cytosol] (Sus scrofa)
        
        MAGOH,MAGOHB [nucleoplasm] (Sus scrofa)
        
        MAGOH [nucleoplasm] (Sus scrofa)
- Processing of Capped Intron-Containing Pre-mRNA (Sus scrofa)
  - Transport of Mature Transcript to Cytoplasm (Sus scrofa)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Sus scrofa)
      - NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Sus scrofa)
        
        NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Sus scrofa)
        
        capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Sus scrofa)
        
        EJC [nucleoplasm] (Sus scrofa)
        
        Core EJC [nucleoplasm] (Sus scrofa)
        
        Magoh-Y14 complex [nucleoplasm] (Sus scrofa)
        
        MAGOH,MAGOHB [nucleoplasm] (Sus scrofa)
        
        MAGOH [nucleoplasm] (Sus scrofa)
        
        polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Sus scrofa)
        
        EJC [nucleoplasm] (Sus scrofa)
        
        Core EJC [nucleoplasm] (Sus scrofa)
        
        Magoh-Y14 complex [nucleoplasm] (Sus scrofa)
        
        MAGOH,MAGOHB [nucleoplasm] (Sus scrofa)
        
        MAGOH [nucleoplasm] (Sus scrofa)
      - Transport of the export-competent mRNP complex through the NPC (Sus scrofa)
        
        NPC:NXF1,2:NXT1:EJC:CBC:mRNA [nucleoplasm] (Sus scrofa)
        
        EJC [nucleoplasm] (Sus scrofa)
        
        Core EJC [nucleoplasm] (Sus scrofa)
        
        Magoh-Y14 complex [nucleoplasm] (Sus scrofa)
        
        MAGOH,MAGOHB [nucleoplasm] (Sus scrofa)
        
        MAGOH [nucleoplasm] (Sus scrofa)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Sus scrofa)
        
        EJC [cytosol] (Sus scrofa)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Sus scrofa)
        
        Magoh-Y14 complex [cytosol] (Sus scrofa)
        
        MAGOH,MAGOHB [nucleoplasm] (Sus scrofa)
        
        MAGOH [nucleoplasm] (Sus scrofa)
      - mRNP complex dissociates from cytosolic face of NPC (Sus scrofa)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Sus scrofa)
        
        EJC [cytosol] (Sus scrofa)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Sus scrofa)
        
        Magoh-Y14 complex [cytosol] (Sus scrofa)
        
        MAGOH,MAGOHB [nucleoplasm] (Sus scrofa)
        
        MAGOH [nucleoplasm] (Sus scrofa)
        
        mRNA:CBC:EJC:POLDIP3 [cytosol] (Sus scrofa)
        
        EJC [cytosol] (Sus scrofa)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Sus scrofa)
        
        Magoh-Y14 complex [cytosol] (Sus scrofa)
        
        MAGOH,MAGOHB [nucleoplasm] (Sus scrofa)
        
        MAGOH [nucleoplasm] (Sus scrofa)
  - mRNA 3'-end processing (Sus scrofa)
    - Cleavage of mRNA at the 3'-end (Sus scrofa)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Sus scrofa)
        
        EJC [nucleoplasm] (Sus scrofa)
        
        Core EJC [nucleoplasm] (Sus scrofa)
        
        Magoh-Y14 complex [nucleoplasm] (Sus scrofa)
        
        MAGOH,MAGOHB [nucleoplasm] (Sus scrofa)
        
        MAGOH [nucleoplasm] (Sus scrofa)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Sus scrofa)
        
        EJC [nucleoplasm] (Sus scrofa)
        
        Core EJC [nucleoplasm] (Sus scrofa)
        
        Magoh-Y14 complex [nucleoplasm] (Sus scrofa)
        
        MAGOH,MAGOHB [nucleoplasm] (Sus scrofa)
        
        MAGOH [nucleoplasm] (Sus scrofa)
    - TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Sus scrofa)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Sus scrofa)
        
        EJC [nucleoplasm] (Sus scrofa)
        
        Core EJC [nucleoplasm] (Sus scrofa)
        
        Magoh-Y14 complex [nucleoplasm] (Sus scrofa)
        
        MAGOH,MAGOHB [nucleoplasm] (Sus scrofa)
        
        MAGOH [nucleoplasm] (Sus scrofa)
      - Spliced mRNP [nucleoplasm] (Sus scrofa)
        
        EJC [nucleoplasm] (Sus scrofa)
        
        Core EJC [nucleoplasm] (Sus scrofa)
        
        Magoh-Y14 complex [nucleoplasm] (Sus scrofa)
        
        MAGOH,MAGOHB [nucleoplasm] (Sus scrofa)
        
        MAGOH [nucleoplasm] (Sus scrofa)
    - mRNA polyadenylation (Sus scrofa)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Sus scrofa)
        
        EJC [nucleoplasm] (Sus scrofa)
        
        Core EJC [nucleoplasm] (Sus scrofa)
        
        Magoh-Y14 complex [nucleoplasm] (Sus scrofa)
        
        MAGOH,MAGOHB [nucleoplasm] (Sus scrofa)
        
        MAGOH [nucleoplasm] (Sus scrofa)
      - polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Sus scrofa)
        
        EJC [nucleoplasm] (Sus scrofa)
        
        Core EJC [nucleoplasm] (Sus scrofa)
        
        Magoh-Y14 complex [nucleoplasm] (Sus scrofa)
        
        MAGOH,MAGOHB [nucleoplasm] (Sus scrofa)
        
        MAGOH [nucleoplasm] (Sus scrofa)
  - mRNA Splicing (Sus scrofa)
    - mRNA Splicing - Major Pathway (Sus scrofa)
      - Formation of the Spliceosomal C* complex (Sus scrofa)
        
        Spliceosomal C complex [nucleoplasm] (Sus scrofa)
        
        Core EJC [nucleoplasm] (Sus scrofa)
        
        Magoh-Y14 complex [nucleoplasm] (Sus scrofa)
        
        MAGOH,MAGOHB [nucleoplasm] (Sus scrofa)
        
        MAGOH [nucleoplasm] (Sus scrofa)
        
        Spliceosomal C* complex [nucleoplasm] (Sus scrofa)
        
        Core EJC [nucleoplasm] (Sus scrofa)
        
        Magoh-Y14 complex [nucleoplasm] (Sus scrofa)
        
        MAGOH,MAGOHB [nucleoplasm] (Sus scrofa)
        
        MAGOH [nucleoplasm] (Sus scrofa)
      - Formation of the Spliceosomal P complex and exon ligation (Sus scrofa)
        
        Spliceosomal C* complex [nucleoplasm] (Sus scrofa)
        
        Core EJC [nucleoplasm] (Sus scrofa)
        
        Magoh-Y14 complex [nucleoplasm] (Sus scrofa)
        
        MAGOH,MAGOHB [nucleoplasm] (Sus scrofa)
        
        MAGOH [nucleoplasm] (Sus scrofa)
        
        Spliceosomal P complex [nucleoplasm] (Sus scrofa)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Sus scrofa)
        
        EJC [nucleoplasm] (Sus scrofa)
        
        Core EJC [nucleoplasm] (Sus scrofa)
        
        Magoh-Y14 complex [nucleoplasm] (Sus scrofa)
        
        MAGOH,MAGOHB [nucleoplasm] (Sus scrofa)
        
        MAGOH [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:F1S766

Reference Genes

BioGPS Gene:100519318

ENSEMBL:ENSSSCG00000003849.5

ENSEMBL:ENSSSCG00005031445.1

KEGG Gene (Sus scrofa):100519318

Monarch:100519318

NCBI Gene:100519318

Reference Transcript

RefSeq:XM_003127999.4

Other Identifiers

100519318

GO:0000184

GO:0000381

GO:0005634

GO:0005681

GO:0008380

GO:0016071

GO:0035145

GO:0043226

GO:0050684

GO:0071013

GO:1990501

GO:2000622

Ssc.4697.1.S1_a_at

Participates

as a member of

MAGOH,MAGOHB [nucleoplasm] (Sus scrofa)

Inferred From

MAGOH [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_003128047.2

Ensembl

ENSSSCP00000004165, ENSSSCT00000004261, ENSSSCG00000003849

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