Reactome | Active mTORC1 complex [lysosomal membrane]

Active mTORC1 complex [lysosomal membrane]

Stable Identifier

R-SSC-165678

Type

Complex

Species

Sus scrofa

Compartment

lysosomal membrane

Locations in the PathwayBrowser

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General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Sus scrofa)
RHEB:GTP [lysosomal membrane] (Sus scrofa)

Participates

as an input of

AKT1S1 (PRAS40) binds mTORC1 (Sus scrofa)
AMPK phosphorylates Raptor in the mTORC1 complex (Sus scrofa)
Rheb in the MTORC1 complex hydrolyses GTP (Sus scrofa)
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Sus scrofa)
Active MTORC1 binds the ULK1 complex (Sus scrofa)

as a component of

mTORC1:RHEB:GTP:p-S183,T246-AKT1S1 [lysosomal membrane] (Sus scrofa)
mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Sus scrofa)
mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Sus scrofa)
MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Sus scrofa)
MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Sus scrofa)

as an output of

Formation of active mTORC1 complex (Sus scrofa)

This entity regulates

Negatively

MAF1 translocates to the nucleus (Sus scrofa)

Inferred From

Active mTORC1 complex [lysosomal membrane] (Homo sapiens)

MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)

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