Reactome | TICAM1 [cytosol]

TICAM1 [cytosol]

Stable Identifier

R-SSC-166170

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

TICAM1, K9J6H0

Locations in the PathwayBrowser

Expand all

Immune System (Sus scrofa)

- Innate Immune System (Sus scrofa)
  - Toll-like Receptor Cascades (Sus scrofa)
    - Toll Like Receptor 4 (TLR4) Cascade (Sus scrofa)
      - MyD88-independent TLR4 cascade (Sus scrofa)
        
        SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Sus scrofa)
        
        SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        TRIF(TICAM1)-mediated TLR4 signaling (Sus scrofa)
        
        Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon (Sus scrofa)
        
        Auto-ubiquitination of TRAF3 (Sus scrofa)
        
        K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Sus scrofa)
        
        activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKE:IRF3/IRF7 [endosome membrane] (Sus scrofa)
        
        activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Sus scrofa)
        
        K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Sus scrofa)
        
        K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex (Sus scrofa)
        
        activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKE:IRF3/IRF7 [endosome membrane] (Sus scrofa)
        
        activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Sus scrofa)
        
        K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Sus scrofa)
        
        K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation (Sus scrofa)
        
        K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Sus scrofa)
        
        K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Sus scrofa)
        
        K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        TANK:K63-poly-Ub-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        TRAF3 binds TICAM1:activated TLR4 complex (Sus scrofa)
        
        SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        IKK complex recruitment mediated by RIP1 (Sus scrofa)
        
        IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Sus scrofa)
        
        CHUK:IKBKB:IKBKG:K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Sus scrofa)
        
        K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        TRIF:activated TLR3/TLR4 complex recruits RIP1 (Sus scrofa)
        
        RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        TRAF6-mediated induction of TAK1 complex within TLR4 complex (Sus scrofa)
        
        Activated TLR4:TICAM1 recruits TRAF6 (Sus scrofa)
        
        SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Sus scrofa)
        
        K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] (Sus scrofa)
        
        K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Sus scrofa)
        
        K63-linked polyUb TRAF6 complexes [endosome membrane] (Sus scrofa)
        
        K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        Activation of TAK1 complex bound to activated TLR4 complex (Sus scrofa)
        
        activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] (Sus scrofa)
        
        K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane] (Sus scrofa)
        
        K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Sus scrofa)
        
        K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        Phosphorylated TAK1 leaves activated TLR receptor complex (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane] (Sus scrofa)
        
        K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        TRIF-mediated programmed cell death (Sus scrofa)
        
        Caspase-8 processing within TLR4 complex (Sus scrofa)
        
        activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        RIP3 binds TRIF to mediate necroptosis (Sus scrofa)
        
        RIP3:TICAM1:activated TLR4 [endosome membrane] (Sus scrofa)
        
        RIP3:RIP1:TICAM1:activated TLR4 [endosome membrane] (Sus scrofa)
        
        RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        RIP3:TICAM1:activated TLR4 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        TRIF:activated TLR4 [endosome membrane] (Sus scrofa)
        
        RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        TLR4-induced ripoptosome assembly (Sus scrofa)
        
        K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Sus scrofa)
      - MyD88 dependent cascade initiated on endosome (Sus scrofa)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
        
        IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Sus scrofa)
        
        Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Sus scrofa)
        
        K63-linked polyUb TRAF6 complexes [endosome membrane] (Sus scrofa)
        
        K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
    - Toll Like Receptor 9 (TLR9) Cascade (Sus scrofa)
      - MyD88 dependent cascade initiated on endosome (Sus scrofa)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
        
        IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Sus scrofa)
        
        Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Sus scrofa)
        
        K63-linked polyUb TRAF6 complexes [endosome membrane] (Sus scrofa)
        
        K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)

Programmed Cell Death (Sus scrofa)

- Apoptosis (Sus scrofa)
  - Caspase activation via extrinsic apoptotic signalling pathway (Sus scrofa)
    - Caspase activation via Death Receptors in the presence of ligand (Sus scrofa)
      - Caspase-8 processing within TLR4 complex (Sus scrofa)
        
        activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)
        
        activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Sus scrofa)
        
        TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        TICAM1 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:K9J6H0

Gene Names

TICAM1

Reference Genes

BioGPS Gene:100623776 TICAM1

ENSEMBL:ENSSSCG00000024771

KEGG Gene (Sus scrofa):100623776 TICAM1

Monarch:100623776 TICAM1

NCBI Gene:100623776 TICAM1

Reference Transcript

RefSeq:NM_001315738.1 TICAM1

Other Identifiers

100623776

GO:0002281

GO:0002376

GO:0002735

GO:0002756

GO:0003674

GO:0003953

GO:0005575

GO:0005622

GO:0005737

GO:0005739

GO:0005773

GO:0005776

GO:0005829

GO:0006464

GO:0006914

GO:0006915

GO:0006950

GO:0006954

GO:0007165

GO:0008150

GO:0008219

GO:0008283

GO:0009056

GO:0009058

GO:0010508

GO:0010628

GO:0012501

GO:0016798

GO:0019899

GO:0019901

GO:0022607

GO:0030890

GO:0031398

GO:0031410

GO:0031663

GO:0032092

GO:0032481

GO:0032496

GO:0032722

GO:0032728

GO:0032755

GO:0032760

GO:0032816

GO:0032991

GO:0034641

GO:0035666

GO:0043123

GO:0043226

GO:0043254

GO:0043330

GO:0045087

GO:0045429

GO:0050871

GO:0050896

GO:0051092

GO:0051607

GO:0065003

GO:0071222

GO:0097190

GO:0097342

GO:0140052

GO:1900017

Participates

as an input of

TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Sus scrofa)

as a component of

TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)

Inferred From

TICAM1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001302667.1

OpenTargets

ENSG00000127666

Ensembl

ENSSSCT00000028315, ENSSSCP00000052008, ENSSSCT00000039816, ENSSSCP00000026412, ENSSSCG00000024771

VGNC

93976

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